BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

168 related articles for article (PubMed ID: 8496936)

  • 1. Synthesis and binding characteristics of potential SPECT imaging agents for sigma-1 and sigma-2 binding sites.
    He XS; Bowen WD; Lee KS; Williams W; Weinberger DR; de Costa BR
    J Med Chem; 1993 Mar; 36(5):566-71. PubMed ID: 8496936
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Rat liver and kidney contain high densities of sigma 1 and sigma 2 receptors: characterization by ligand binding and photoaffinity labeling.
    Hellewell SB; Bruce A; Feinstein G; Orringer J; Williams W; Bowen WD
    Eur J Pharmacol; 1994 Jun; 268(1):9-18. PubMed ID: 7925616
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and receptor binding properties of fluoro- and iodo-substituted high affinity sigma receptor ligands: identification of potential PET and SPECT sigma receptor imaging agents.
    de Costa B; Radesca L; Dominguez C; Di Paolo L; Bowen WD
    J Med Chem; 1992 Jun; 35(12):2221-30. PubMed ID: 1319493
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A new approach to the design of sigma-2-selective ligands: synthesis and evaluation of N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1- pyrrolidinyl)ethylamine-related polyamines at sigma-1 and sigma-2 receptor subtypes.
    de Costa BR; He XS; Dominguez C; Cutts J; Williams W; Bowen WD
    J Med Chem; 1994 Jan; 37(2):314-21. PubMed ID: 8295220
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and biological evaluation of conformationally restricted 2-(1-pyrrolidinyl)-N-[2-(3,4-dichlorophenyl)ethyl]-N-methylethylenediam ines as sigma receptor ligands. 1. Pyrrolidine, piperidine, homopiperidine, and tetrahydroisoquinoline classes.
    de Costa BR; Dominguez C; He XS; Williams W; Radesca L; Bowen W
    J Med Chem; 1992 Nov; 35(23):4334-43. PubMed ID: 1447735
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis, in vitro validation and in vivo pharmacokinetics of [125I]N-[2-(4-iodophenyl)ethyl]-N-methyl-2-(1-piperidinyl) ethylamine: a high-affinity ligand for imaging sigma receptor positive tumors.
    John CS; Gulden ME; Vilner BJ; Bowen WD
    Nucl Med Biol; 1996 Aug; 23(6):761-6. PubMed ID: 8940718
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Substituted halogenated arylsulfonamides: a new class of sigma receptor binding tumor imaging agents.
    John CS; Lim BB; Vilner BJ; Geyer BC; Bowen WD
    J Med Chem; 1998 Jul; 41(14):2445-50. PubMed ID: 9651150
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity sigma receptor ligands. Identification of a new class of highly potent and selective sigma receptor probes.
    de Costa BR; Rice KC; Bowen WD; Thurkauf A; Rothman RB; Band L; Jacobson AE; Radesca L; Contreras PC; Gray NM
    J Med Chem; 1990 Nov; 33(11):3100-10. PubMed ID: 2172538
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and evaluation of conformationally restricted N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamines at sigma receptors. 2. Piperazines, bicyclic amines, bridged bicyclic amines, and miscellaneous compounds.
    de Costa BR; He XS; Linders JT; Dominguez C; Gu ZQ; Williams W; Bowen WD
    J Med Chem; 1993 Aug; 36(16):2311-20. PubMed ID: 8360875
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines: structural requirements and binding affinity at the sigma receptor.
    de Costa BR; Radesca L; Di Paolo L; Bowen WD
    J Med Chem; 1992 Jan; 35(1):38-47. PubMed ID: 1310114
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Comparison of binding parameters of sigma 1 and sigma 2 binding sites in rat and guinea pig brain membranes: novel subtype-selective trishomocubanes.
    Nguyen VH; Kassiou M; Johnston GA; Christie MJ
    Eur J Pharmacol; 1996 Sep; 311(2-3):233-40. PubMed ID: 8891604
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Differentiation of sigma ligand-activated receptor subtypes that modulate NMDA-evoked [3H]-noradrenaline release in rat hippocampal slices.
    Monnet FP; de Costa BR; Bowen WD
    Br J Pharmacol; 1996 Sep; 119(1):65-72. PubMed ID: 8872358
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and in vitro evaluation of iodinated derivatives of piperazine as a new ligand for sigma receptor imaging by single photon emission computed tomography.
    Hirata M; Mori T; Soga S; Umeda T; Ohmomo Y
    Chem Pharm Bull (Tokyo); 2006 Apr; 54(4):470-5. PubMed ID: 16595947
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Kappa opioid receptor agonists inhibit sigma-1 (sigma 1) receptor binding in guinea-pig brain, liver and spleen: autoradiographical evidence.
    Brent PJ
    Brain Res; 1996 Jul; 725(2):155-65. PubMed ID: 8836521
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Subchronic administration of N-[2-(3,4-dichlorophenyl) ethyl]-N-methyl-2-(dimethylamino) ethylamine (BD1047) alters sigma 1 receptor binding.
    Zambon AC; De Costa BR; Kanthasamy AG; Nguyen BQ; Matsumoto RR
    Eur J Pharmacol; 1997 Apr; 324(1):39-47. PubMed ID: 9137911
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain.
    Hellewell SB; Bowen WD
    Brain Res; 1990 Sep; 527(2):244-53. PubMed ID: 2174717
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis, in vitro pharmacologic characterization, and preclinical evaluation of N-[2-(1'-piperidinyl)ethyl]-3-[125I]iodo-4-methoxybenzamide (P[125I]MBA) for imaging breast cancer.
    John CS; Bowen WD; Fisher SJ; Lim BB; Geyer BC; Vilner BJ; Wahl RL
    Nucl Med Biol; 1999 May; 26(4):377-82. PubMed ID: 10382840
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and evaluation of aryl-substituted N-(arylethyl)-N-methyl-2-(1-pyrrolidinyl)ethylamines and corresponding arylacetamides for sigma receptor affinity.
    Zhang Y; Williams W; Bowen WD; Rice KC
    J Med Chem; 1996 Aug; 39(18):3564-8. PubMed ID: 8784455
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Probes for narcotic receptor mediated phenomena. 17. Synthesis and evaluation of a series of trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacet amide (U50,488) related isothiocyanate derivatives as opioid receptor affinity ligands.
    de Costa BR; Rothman RB; Bykov V; Band L; Pert A; Jacobson AE; Rice KC
    J Med Chem; 1990 Apr; 33(4):1171-6. PubMed ID: 2157008
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands.
    de Costa BR; Bowen WD; Hellewell SB; George C; Rothman RB; Reid AA; Walker JM; Jacobson AE; Rice KC
    J Med Chem; 1989 Aug; 32(8):1996-2002. PubMed ID: 2547074
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.