These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
497 related articles for article (PubMed ID: 8504753)
1. Steroid 17 alpha-hydroxylase and 17,20-lyase activities of P450c17: contributions of serine106 and P450 reductase. Lin D; Black SM; Nagahama Y; Miller WL Endocrinology; 1993 Jun; 132(6):2498-506. PubMed ID: 8504753 [TBL] [Abstract][Full Text] [Related]
2. P450c17 mutations R347H and R358Q selectively disrupt 17,20-lyase activity by disrupting interactions with P450 oxidoreductase and cytochrome b5. Geller DH; Auchus RJ; Miller WL Mol Endocrinol; 1999 Jan; 13(1):167-75. PubMed ID: 9892022 [TBL] [Abstract][Full Text] [Related]
3. Modeling and mutagenesis of the active site of human P450c17. Lin D; Zhang LH; Chiao E; Miller WL Mol Endocrinol; 1994 Mar; 8(3):392-402. PubMed ID: 8015556 [TBL] [Abstract][Full Text] [Related]
4. Progesterone 16 alpha-hydroxylase activity is catalyzed by human cytochrome P450 17 alpha-hydroxylase. Swart P; Swart AC; Waterman MR; Estabrook RW; Mason JI J Clin Endocrinol Metab; 1993 Jul; 77(1):98-102. PubMed ID: 8325965 [TBL] [Abstract][Full Text] [Related]
5. The regulation of 17,20 lyase activity. Miller WL; Auchus RJ; Geller DH Steroids; 1997 Jan; 62(1):133-42. PubMed ID: 9029728 [TBL] [Abstract][Full Text] [Related]
6. Molecular cloning and expression of guinea pig cytochrome P450c17 cDNA (steroid 17 alpha-hydroxylase/17,20 lyase): tissue distribution, regulation, and substrate specificity of the expressed enzyme. Tremblay Y; Fleury A; Beaudoin C; Vallée M; Bélanger A DNA Cell Biol; 1994 Dec; 13(12):1199-212. PubMed ID: 7811386 [TBL] [Abstract][Full Text] [Related]
7. NADPH-flavodoxin reductase and flavodoxin from Escherichia coli: characteristics as a soluble microsomal P450 reductase. Jenkins CM; Waterman MR Biochemistry; 1998 Apr; 37(17):6106-13. PubMed ID: 9558349 [TBL] [Abstract][Full Text] [Related]
8. Assessment of the ability of type 2 cytochrome b5 to modulate 17,20-lyase activity of human P450c17. Soucy P; Luu-The V J Steroid Biochem Mol Biol; 2002 Jan; 80(1):71-5. PubMed ID: 11867265 [TBL] [Abstract][Full Text] [Related]
9. Expression and purification of functional human 17 alpha-hydroxylase/17,20-lyase (P450c17) in Escherichia coli. Use of this system for study of a novel form of combined 17 alpha-hydroxylase/17,20-lyase deficiency. Imai T; Globerman H; Gertner JM; Kagawa N; Waterman MR J Biol Chem; 1993 Sep; 268(26):19681-9. PubMed ID: 8396144 [TBL] [Abstract][Full Text] [Related]
10. Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations. Auchus RJ; Miller WL Mol Endocrinol; 1999 Jul; 13(7):1169-82. PubMed ID: 10406467 [TBL] [Abstract][Full Text] [Related]
11. Genetically engineered P450 monooxygenases: construction of bovine P450c17/yeast reductase fused enzymes. Shibata M; Sakaki T; Yabusaki Y; Murakami H; Ohkawa H DNA Cell Biol; 1990; 9(1):27-36. PubMed ID: 2180429 [TBL] [Abstract][Full Text] [Related]
12. The role of cytochrome b5 in the biosynthesis of androgens by human P450c17. Katagiri M; Kagawa N; Waterman MR Arch Biochem Biophys; 1995 Mar; 317(2):343-7. PubMed ID: 7893148 [TBL] [Abstract][Full Text] [Related]
13. Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17. Pandey AV; Miller WL J Biol Chem; 2005 Apr; 280(14):13265-71. PubMed ID: 15687493 [TBL] [Abstract][Full Text] [Related]
14. Comparison of the 17 alpha-hydroxylase/C17,20-lyase activities of porcine, guinea pig and bovine P450c17 using purified recombinant fusion proteins containing P450c17 linked to NADPH-P450 reductase. Shet MS; Fisher CW; Tremblay Y; Belanger A; Conley AJ; Mason JI; Estabrook RW Drug Metab Rev; 2007; 39(2-3):289-307. PubMed ID: 17786622 [TBL] [Abstract][Full Text] [Related]
15. Characterization of the adrenal cytochrome P450C17 in the hamster, a small animal model for the study of adrenal dehydroepiandrosterone biosynthesis. Cloutier M; Fleury A; Courtemanche J; Ducharme L; Mason JI; Lehoux JG DNA Cell Biol; 1997 Mar; 16(3):357-68. PubMed ID: 9115645 [TBL] [Abstract][Full Text] [Related]
17. Pathways leading to phosphorylation of p450c17 and to the posttranslational regulation of androgen biosynthesis. Tee MK; Dong Q; Miller WL Endocrinology; 2008 May; 149(5):2667-77. PubMed ID: 18187541 [TBL] [Abstract][Full Text] [Related]
18. Dissociation of hydroxylase and lyase activities by site-directed mutagenesis of the rat P45017 alpha. Kitamura M; Buczko E; Dufau ML Mol Endocrinol; 1991 Oct; 5(10):1373-80. PubMed ID: 1723139 [TBL] [Abstract][Full Text] [Related]
19. Biochemical differences between rat and human cytochrome P450c17 support the different steroidogenic needs of these two species. Brock BJ; Waterman MR Biochemistry; 1999 Feb; 38(5):1598-606. PubMed ID: 9931027 [TBL] [Abstract][Full Text] [Related]
20. The primate adrenal zona reticularis is defined by expression of cytochrome b5, 17alpha-hydroxylase/17,20-lyase cytochrome P450 (P450c17) and NADPH-cytochrome P450 reductase (reductase) but not 3beta-hydroxysteroid dehydrogenase/delta5-4 isomerase (3beta-HSD). Mapes S; Corbin CJ; Tarantal A; Conley A J Clin Endocrinol Metab; 1999 Sep; 84(9):3382-5. PubMed ID: 10487714 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]