502 related articles for article (PubMed ID: 8504753)
1. Steroid 17 alpha-hydroxylase and 17,20-lyase activities of P450c17: contributions of serine106 and P450 reductase.
Lin D; Black SM; Nagahama Y; Miller WL
Endocrinology; 1993 Jun; 132(6):2498-506. PubMed ID: 8504753
[TBL] [Abstract][Full Text] [Related]
2. P450c17 mutations R347H and R358Q selectively disrupt 17,20-lyase activity by disrupting interactions with P450 oxidoreductase and cytochrome b5.
Geller DH; Auchus RJ; Miller WL
Mol Endocrinol; 1999 Jan; 13(1):167-75. PubMed ID: 9892022
[TBL] [Abstract][Full Text] [Related]
3. Modeling and mutagenesis of the active site of human P450c17.
Lin D; Zhang LH; Chiao E; Miller WL
Mol Endocrinol; 1994 Mar; 8(3):392-402. PubMed ID: 8015556
[TBL] [Abstract][Full Text] [Related]
4. Progesterone 16 alpha-hydroxylase activity is catalyzed by human cytochrome P450 17 alpha-hydroxylase.
Swart P; Swart AC; Waterman MR; Estabrook RW; Mason JI
J Clin Endocrinol Metab; 1993 Jul; 77(1):98-102. PubMed ID: 8325965
[TBL] [Abstract][Full Text] [Related]
5. The regulation of 17,20 lyase activity.
Miller WL; Auchus RJ; Geller DH
Steroids; 1997 Jan; 62(1):133-42. PubMed ID: 9029728
[TBL] [Abstract][Full Text] [Related]
6. Molecular cloning and expression of guinea pig cytochrome P450c17 cDNA (steroid 17 alpha-hydroxylase/17,20 lyase): tissue distribution, regulation, and substrate specificity of the expressed enzyme.
Tremblay Y; Fleury A; Beaudoin C; Vallée M; Bélanger A
DNA Cell Biol; 1994 Dec; 13(12):1199-212. PubMed ID: 7811386
[TBL] [Abstract][Full Text] [Related]
7. NADPH-flavodoxin reductase and flavodoxin from Escherichia coli: characteristics as a soluble microsomal P450 reductase.
Jenkins CM; Waterman MR
Biochemistry; 1998 Apr; 37(17):6106-13. PubMed ID: 9558349
[TBL] [Abstract][Full Text] [Related]
8. Assessment of the ability of type 2 cytochrome b5 to modulate 17,20-lyase activity of human P450c17.
Soucy P; Luu-The V
J Steroid Biochem Mol Biol; 2002 Jan; 80(1):71-5. PubMed ID: 11867265
[TBL] [Abstract][Full Text] [Related]
9. Expression and purification of functional human 17 alpha-hydroxylase/17,20-lyase (P450c17) in Escherichia coli. Use of this system for study of a novel form of combined 17 alpha-hydroxylase/17,20-lyase deficiency.
Imai T; Globerman H; Gertner JM; Kagawa N; Waterman MR
J Biol Chem; 1993 Sep; 268(26):19681-9. PubMed ID: 8396144
[TBL] [Abstract][Full Text] [Related]
10. Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations.
Auchus RJ; Miller WL
Mol Endocrinol; 1999 Jul; 13(7):1169-82. PubMed ID: 10406467
[TBL] [Abstract][Full Text] [Related]
11. Genetically engineered P450 monooxygenases: construction of bovine P450c17/yeast reductase fused enzymes.
Shibata M; Sakaki T; Yabusaki Y; Murakami H; Ohkawa H
DNA Cell Biol; 1990; 9(1):27-36. PubMed ID: 2180429
[TBL] [Abstract][Full Text] [Related]
12. The role of cytochrome b5 in the biosynthesis of androgens by human P450c17.
Katagiri M; Kagawa N; Waterman MR
Arch Biochem Biophys; 1995 Mar; 317(2):343-7. PubMed ID: 7893148
[TBL] [Abstract][Full Text] [Related]
13. Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17.
Pandey AV; Miller WL
J Biol Chem; 2005 Apr; 280(14):13265-71. PubMed ID: 15687493
[TBL] [Abstract][Full Text] [Related]
14. Comparison of the 17 alpha-hydroxylase/C17,20-lyase activities of porcine, guinea pig and bovine P450c17 using purified recombinant fusion proteins containing P450c17 linked to NADPH-P450 reductase.
Shet MS; Fisher CW; Tremblay Y; Belanger A; Conley AJ; Mason JI; Estabrook RW
Drug Metab Rev; 2007; 39(2-3):289-307. PubMed ID: 17786622
[TBL] [Abstract][Full Text] [Related]
15. Characterization of the adrenal cytochrome P450C17 in the hamster, a small animal model for the study of adrenal dehydroepiandrosterone biosynthesis.
Cloutier M; Fleury A; Courtemanche J; Ducharme L; Mason JI; Lehoux JG
DNA Cell Biol; 1997 Mar; 16(3):357-68. PubMed ID: 9115645
[TBL] [Abstract][Full Text] [Related]
16. Pitfalls in characterizing P450c17 mutations associated with isolated 17,20-lyase deficiency.
Gupta MK; Geller DH; Auchus RJ
J Clin Endocrinol Metab; 2001 Sep; 86(9):4416-23. PubMed ID: 11549685
[TBL] [Abstract][Full Text] [Related]
17. Pathways leading to phosphorylation of p450c17 and to the posttranslational regulation of androgen biosynthesis.
Tee MK; Dong Q; Miller WL
Endocrinology; 2008 May; 149(5):2667-77. PubMed ID: 18187541
[TBL] [Abstract][Full Text] [Related]
18. Dissociation of hydroxylase and lyase activities by site-directed mutagenesis of the rat P45017 alpha.
Kitamura M; Buczko E; Dufau ML
Mol Endocrinol; 1991 Oct; 5(10):1373-80. PubMed ID: 1723139
[TBL] [Abstract][Full Text] [Related]
19. Biochemical differences between rat and human cytochrome P450c17 support the different steroidogenic needs of these two species.
Brock BJ; Waterman MR
Biochemistry; 1999 Feb; 38(5):1598-606. PubMed ID: 9931027
[TBL] [Abstract][Full Text] [Related]
20. The primate adrenal zona reticularis is defined by expression of cytochrome b5, 17alpha-hydroxylase/17,20-lyase cytochrome P450 (P450c17) and NADPH-cytochrome P450 reductase (reductase) but not 3beta-hydroxysteroid dehydrogenase/delta5-4 isomerase (3beta-HSD).
Mapes S; Corbin CJ; Tarantal A; Conley A
J Clin Endocrinol Metab; 1999 Sep; 84(9):3382-5. PubMed ID: 10487714
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
