219 related articles for article (PubMed ID: 8512814)
1. Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells.
Baer JC; Freeman AA; Newlands ES; Watson AJ; Rafferty JA; Margison GP
Br J Cancer; 1993 Jun; 67(6):1299-302. PubMed ID: 8512814
[TBL] [Abstract][Full Text] [Related]
2. O6-benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA alkyltransferase activity to temozolomide and BCNU.
Wedge SR; Newlands ES
Br J Cancer; 1996 May; 73(9):1049-52. PubMed ID: 8624262
[TBL] [Abstract][Full Text] [Related]
3. Potentiation of temozolomide and BCNU cytotoxicity by O(6)-benzylguanine: a comparative study in vitro.
Wedge SR; Porteus JK; May BL; Newlands ES
Br J Cancer; 1996 Feb; 73(4):482-90. PubMed ID: 8595163
[TBL] [Abstract][Full Text] [Related]
4. Effect of single and multiple administration of an O6-benzylguanine/temozolomide combination: an evaluation in a human melanoma xenograft model.
Wedge SR; Porteous JK; Newlands ES
Cancer Chemother Pharmacol; 1997; 40(3):266-72. PubMed ID: 9219512
[TBL] [Abstract][Full Text] [Related]
5. 3-aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity.
Wedge SR; Porteous JK; Newlands ES
Br J Cancer; 1996 Oct; 74(7):1030-6. PubMed ID: 8855970
[TBL] [Abstract][Full Text] [Related]
6. O6-benzylguanine increases the sensitivity of human primary bone marrow cells to the cytotoxic effects of temozolomide.
Fairbairn LJ; Watson AJ; Rafferty JA; Elder RH; Margison GP
Exp Hematol; 1995 Feb; 23(2):112-6. PubMed ID: 7828668
[TBL] [Abstract][Full Text] [Related]
7. Inactivation of O6-alkylguanine-DNA alkyltransferase in human peripheral blood mononuclear cells by temozolomide.
Lee SM; Thatcher N; Crowther D; Margison GP
Br J Cancer; 1994 Mar; 69(3):452-6. PubMed ID: 8123472
[TBL] [Abstract][Full Text] [Related]
8. Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.
Dolan ME; Moschel RC; Pegg AE
Proc Natl Acad Sci U S A; 1990 Jul; 87(14):5368-72. PubMed ID: 2164681
[TBL] [Abstract][Full Text] [Related]
9. In vitro evaluation of temozolomide combined with X-irradiation.
Wedge SR; Porteous JK; Glaser MG; Marcus K; Newlands ES
Anticancer Drugs; 1997 Jan; 8(1):92-7. PubMed ID: 9147618
[TBL] [Abstract][Full Text] [Related]
10. Influence of O6-methylguanine on DNA damage and cytotoxicity of temozolomide in L1210 mouse leukemia sensitive and resistant to chloroethylnitrosoureas.
Taverna P; Catapano CV; Citti L; Bonfanti M; D'Incalci M
Anticancer Drugs; 1992 Aug; 3(4):401-5. PubMed ID: 1421437
[TBL] [Abstract][Full Text] [Related]
11. O6-alkylguanine-DNA-alkyltransferase activity and nitrosourea sensitivity in human cancer cell lines.
Walker MC; Masters JR; Margison GP
Br J Cancer; 1992 Nov; 66(5):840-3. PubMed ID: 1419626
[TBL] [Abstract][Full Text] [Related]
12. In vivo depletion of O6-alkylguanine-DNA-alkyltransferase in lymphocytes and melanoma of patients treated with CB 10-277, a new DTIC analogue.
Lee SM; Thatcher N; Crowther D; Margison GP
Cancer Chemother Pharmacol; 1992; 31(3):240-6. PubMed ID: 1464162
[TBL] [Abstract][Full Text] [Related]
13. O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines.
Bobola MS; Silber JR; Ellenbogen RG; Geyer JR; Blank A; Goff RD
Clin Cancer Res; 2005 Apr; 11(7):2747-55. PubMed ID: 15814657
[TBL] [Abstract][Full Text] [Related]
14. New cytotoxic agents for the treatment of metastatic malignant melanoma: temozolomide and related alkylating agents in combination with guanine analogues to abrogate drug resistance.
Spiro T; Liu L; Gerson S
Forum (Genova); 2000; 10(3):274-85. PubMed ID: 11007934
[TBL] [Abstract][Full Text] [Related]
15. Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea.
Liu L; Markowitz S; Gerson SL
Cancer Res; 1996 Dec; 56(23):5375-9. PubMed ID: 8968088
[TBL] [Abstract][Full Text] [Related]
16. Protection of mammalian cells against chloroethylating agent toxicity by an O6-benzylguanine-resistant mutant of human O6-alkylguanine-DNA alkyltransferase.
Hickson I; Fairbairn LJ; Chinnasamy N; Dexter TM; Margison GP; Rafferty JA
Gene Ther; 1996 Oct; 3(10):868-77. PubMed ID: 8908500
[TBL] [Abstract][Full Text] [Related]
17. Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases.
Cai Y; Wu MH; Xu-Welliver M; Pegg AE; Ludeman SM; Dolan ME
Cancer Res; 2000 Oct; 60(19):5464-9. PubMed ID: 11034089
[TBL] [Abstract][Full Text] [Related]
18. O6-methylguanine-DNA-methyltransferase promoter demethylation is involved in basic fibroblast growth factor induced resistance against temozolomide in human melanoma cells.
Fontijn D; Adema AD; Bhakat KK; Pinedo HM; Peters GJ; Boven E
Mol Cancer Ther; 2007 Oct; 6(10):2807-15. PubMed ID: 17938272
[TBL] [Abstract][Full Text] [Related]
19. O(6)-(4-bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts.
Middleton MR; Kelly J; Thatcher N; Donnelly DJ; McElhinney RS; McMurry TB; McCormick JE; Margison GP
Int J Cancer; 2000 Jan; 85(2):248-52. PubMed ID: 10629085
[TBL] [Abstract][Full Text] [Related]
20. Relationships among cell survival, O6-alkylguanine-DNA alkyltransferase activity, and reactivation of methylated adenovirus 5 and herpes simplex virus type 1 in human melanoma cell lines.
Maynard K; Parsons PG; Cerny T; Margison GP
Cancer Res; 1989 Sep; 49(17):4813-7. PubMed ID: 2547518
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
