BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

153 related articles for article (PubMed ID: 8530393)

  • 1. Kinetic characterization of channel impaired mutants of tryptophan synthase.
    Anderson KS; Kim AY; Quillen JM; Sayers E; Yang XJ; Miles EW
    J Biol Chem; 1995 Dec; 270(50):29936-44. PubMed ID: 8530393
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural and kinetic analysis of a channel-impaired mutant of tryptophan synthase.
    Schlichting I; Yang XJ; Miles EW; Kim AY; Anderson KS
    J Biol Chem; 1994 Oct; 269(43):26591-3. PubMed ID: 7929385
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The tryptophan synthase bienzyme complex transfers indole between the alpha- and beta-sites via a 25-30 A long tunnel.
    Dunn MF; Aguilar V; Brzović P; Drewe WF; Houben KF; Leja CA; Roy M
    Biochemistry; 1990 Sep; 29(37):8598-607. PubMed ID: 2271543
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Serine modulates substrate channeling in tryptophan synthase. A novel intersubunit triggering mechanism.
    Anderson KS; Miles EW; Johnson KA
    J Biol Chem; 1991 May; 266(13):8020-33. PubMed ID: 1902468
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Characterization of the functional role of a flexible loop in the alpha-subunit of tryptophan synthase from Salmonella typhimurium by rapid-scanning, stopped-flow spectroscopy and site-directed mutagenesis.
    Brzović PS; Hyde CC; Miles EW; Dunn MF
    Biochemistry; 1993 Oct; 32(39):10404-13. PubMed ID: 8399184
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Ligand-mediated changes in the tryptophan synthase indole tunnel probed by nile red fluorescence with wild type, mutant, and chemically modified enzymes.
    Ruvinov SB; Yang XJ; Parris KD; Banik U; Ahmed SA; Miles EW; Sackett DL
    J Biol Chem; 1995 Mar; 270(11):6357-69. PubMed ID: 7890774
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural basis for the impaired channeling and allosteric inter-subunit communication in the beta A169L/beta C170W mutant of tryptophan synthase.
    Weyand M; Schlichting I
    J Biol Chem; 2000 Dec; 275(52):41058-63. PubMed ID: 11034989
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Evidence that mutations in a loop region of the alpha-subunit inhibit the transition from an open to a closed conformation in the tryptophan synthase bienzyme complex.
    Brzović PS; Sawa Y; Hyde CC; Miles EW; Dunn MF
    J Biol Chem; 1992 Jun; 267(18):13028-38. PubMed ID: 1618800
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Microspectrophotometric studies on single crystals of the tryptophan synthase alpha 2 beta 2 complex demonstrate formation of enzyme-substrate intermediates.
    Mozzarelli A; Peracchi A; Rossi GL; Ahmed SA; Miles EW
    J Biol Chem; 1989 Sep; 264(27):15774-80. PubMed ID: 2506170
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Tryptophan synthase: a multienzyme complex with an intramolecular tunnel.
    Miles EW
    Chem Rec; 2001; 1(2):140-51. PubMed ID: 11893063
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Site-specific mutagenesis of the alpha subunit of tryptophan synthase from Salmonella typhimurium. Changing arginine 179 to leucine alters the reciprocal transmission of substrate-induced conformational changes between the alpha and beta 2 subunits.
    Kawasaki H; Bauerle R; Zon G; Ahmed SA; Miles EW
    J Biol Chem; 1987 Aug; 262(22):10678-83. PubMed ID: 3112150
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mechanism of mutual activation of the tryptophan synthase alpha and beta subunits. Analysis of the reaction specificity and substrate-induced inactivation of active site and tunnel mutants of the beta subunit.
    Ahmed SA; Ruvinov SB; Kayastha AM; Miles EW
    J Biol Chem; 1991 Nov; 266(32):21548-57. PubMed ID: 1939184
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Conformational changes and subunit communication in tryptophan synthase: effect of substrates and substrate analogs.
    Strambini GB; Cioni P; Peracchi A; Mozzarelli A
    Biochemistry; 1992 Aug; 31(33):7535-42. PubMed ID: 1510940
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Monovalent metal ions play an essential role in catalysis and intersubunit communication in the tryptophan synthase bienzyme complex.
    Woehl EU; Dunn MF
    Biochemistry; 1995 Jul; 34(29):9466-76. PubMed ID: 7626617
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A novel intersubunit repair mechanism in the tryptophan synthase alpha 2 beta 2 complex. Critical role of the beta subunit lysine 167 in intersubunit communication.
    Yang XJ; Miles EW
    J Biol Chem; 1993 Oct; 268(30):22269-72. PubMed ID: 8226734
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Evidence for two conformers of the beta subunit of tryptophan synthase in solution.
    Ahmed SA; Miles EW
    J Biol Chem; 1992 Nov; 267(32):23309-17. PubMed ID: 1429678
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Tryptophan synthase: structure and function of the monovalent cation site.
    Dierkers AT; Niks D; Schlichting I; Dunn MF
    Biochemistry; 2009 Nov; 48(46):10997-1010. PubMed ID: 19848417
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mutagenic analysis of the interior packing of an alpha/beta barrel protein. Effects on the stabilities and rates of interconversion of the native and partially folded forms of the alpha subunit of tryptophan synthase.
    Tsuji T; Chrunyk BA; Chen X; Matthews CR
    Biochemistry; 1993 Jun; 32(21):5566-75. PubMed ID: 8504078
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and characterization of allosteric probes of substrate channeling in the tryptophan synthase bienzyme complex.
    Ngo H; Harris R; Kimmich N; Casino P; Niks D; Blumenstein L; Barends TR; Kulik V; Weyand M; Schlichting I; Dunn MF
    Biochemistry; 2007 Jul; 46(26):7713-27. PubMed ID: 17559195
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Threonine 183 and adjacent flexible loop residues in the tryptophan synthase alpha subunit have critical roles in modulating the enzymatic activities of the beta subunit in the alpha 2 beta 2 complex.
    Yang XJ; Miles EW
    J Biol Chem; 1992 Apr; 267(11):7520-8. PubMed ID: 1559990
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.