These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

145 related articles for article (PubMed ID: 8531117)

  • 1. The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man.
    Maggs JL; Williams D; Pirmohamed M; Park BK
    J Pharmacol Exp Ther; 1995 Dec; 275(3):1463-75. PubMed ID: 8531117
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: possible role in agranulocytosis.
    Williams DP; Pirmohamed M; Naisbitt DJ; Maggs JL; Park BK
    J Pharmacol Exp Ther; 1997 Dec; 283(3):1375-82. PubMed ID: 9400013
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Possible role of free radical formation in clozapine (clozaril)-induced agranulocytosis.
    Fischer V; Haar JA; Greiner L; Lloyd RV; Mason RP
    Mol Pharmacol; 1991 Nov; 40(5):846-53. PubMed ID: 1658615
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Role of human glutathione S-transferases in the inactivation of reactive metabolites of clozapine.
    Dragovic S; Boerma JS; van Bergen L; Vermeulen NP; Commandeur JN
    Chem Res Toxicol; 2010 Sep; 23(9):1467-76. PubMed ID: 20849150
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A comparison of the covalent binding of clozapine, procainamide, and vesnarinone to human neutrophils in vitro and rat tissues in vitro and in vivo.
    Gardner I; Popović M; Zahid N; Uetrecht JP
    Chem Res Toxicol; 2005 Sep; 18(9):1384-94. PubMed ID: 16167830
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells.
    Liu ZC; Uetrecht JP
    J Pharmacol Exp Ther; 1995 Dec; 275(3):1476-83. PubMed ID: 8531118
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The cytotoxicity of clozapine metabolites: implications for predicting clozapine-induced agranulocytosis.
    Tschen AC; Rieder MJ; Oyewumi LK; Freeman DJ
    Clin Pharmacol Ther; 1999 May; 65(5):526-32. PubMed ID: 10340918
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Testing the hypothesis that selenium deficiency is a risk factor for clozapine-induced agranulocytosis in rats.
    Ip J; Uetrecht JP
    Chem Res Toxicol; 2008 Apr; 21(4):874-8. PubMed ID: 18380444
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Potential role of a quetiapine metabolite in quetiapine-induced neutropenia and agranulocytosis.
    Li X; Cameron MD
    Chem Res Toxicol; 2012 May; 25(5):1004-11. PubMed ID: 22506851
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Metabolism and bioactivation of clozapine by human liver in vitro.
    Pirmohamed M; Williams D; Madden S; Templeton E; Park BK
    J Pharmacol Exp Ther; 1995 Mar; 272(3):984-90. PubMed ID: 7891353
    [TBL] [Abstract][Full Text] [Related]  

  • 11. NTP technical report on the toxicity and metabolism studies of chloral hydrate (CAS No. 302-17-0). Administered by gavage to F344/N rats and B6C3F1 mice.
    Beland FA
    Toxic Rep Ser; 1999 Aug; (59):1-66, A1-E7. PubMed ID: 11803702
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro.
    Williams DP; O'Donnell CJ; Maggs JL; Leeder JS; Uetrecht J; Pirmohamed M; Park BK
    Chem Res Toxicol; 2003 Oct; 16(10):1359-64. PubMed ID: 14565776
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Involvement of myeloperoxidase and NADPH oxidase in the covalent binding of amodiaquine and clozapine to neutrophils: implications for drug-induced agranulocytosis.
    Lobach AR; Uetrecht J
    Chem Res Toxicol; 2014 Apr; 27(4):699-709. PubMed ID: 24588327
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Clozapine bioactivation induces dose-dependent, drug-specific toxicity of human bone marrow stromal cells: a potential in vitro system for the study of agranulocytosis.
    Pereira A; Dean B
    Biochem Pharmacol; 2006 Sep; 72(6):783-93. PubMed ID: 16844094
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A comparison of the covalent binding of clozapine and olanzapine to human neutrophils in vitro and in vivo.
    Gardner I; Leeder JS; Chin T; Zahid N; Uetrecht JP
    Mol Pharmacol; 1998 Jun; 53(6):999-1008. PubMed ID: 9614201
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Bioactivation and covalent binding of hydroxyfluperlapine in human neutrophils: implications for fluperlapine-induced agranulocytosis.
    Lai WG; Gardner I; Zahid N; Uetrecht JP
    Drug Metab Dispos; 2000 Mar; 28(3):255-63. PubMed ID: 10681368
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediate: correlation of in vitro and in vivo generation of reactive intermediates and in vitro glutathione conjugate formation in rats and humans.
    Masubuchi N; Makino C; Murayama N
    Chem Res Toxicol; 2007 Mar; 20(3):455-64. PubMed ID: 17309281
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Role of residue 87 in the activity and regioselectivity of clozapine metabolism by drug-metabolizing CYP102A1 M11H: application for structural characterization of clozapine GSH conjugates.
    Rea V; Dragovic S; Boerma JS; de Kanter FJ; Vermeulen NP; Commandeur JN
    Drug Metab Dispos; 2011 Dec; 39(12):2411-20. PubMed ID: 21890734
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Predicting drug-induced agranulocytosis: characterizing neutrophil-generated metabolites of a model compound, DMP 406, and assessing the relevance of an in vitro apoptosis assay for identifying drugs that may cause agranulocytosis.
    Iverson S; Zahid N; Uetrecht JP
    Chem Biol Interact; 2002 Nov; 142(1-2):175-99. PubMed ID: 12399162
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Bioactivation of coumarin in rat olfactory mucosal microsomes: Detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts.
    Zhuo X; Zhao W; Zheng J; Humphreys WG; Shu YZ; Zhu M
    Chem Biol Interact; 2009 Oct; 181(2):227-35. PubMed ID: 19576871
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.