BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

244 related articles for article (PubMed ID: 8573182)

  • 1. Missense mutations associated with familial Alzheimer's disease in Sweden lead to the production of the amyloid peptide without internalization of its precursor.
    Essalmani R; Macq AF; Mercken L; Octave JN
    Biochem Biophys Res Commun; 1996 Jan; 218(1):89-96. PubMed ID: 8573182
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.
    Citron M; Oltersdorf T; Haass C; McConlogue L; Hung AY; Seubert P; Vigo-Pelfrey C; Lieberburg I; Selkoe DJ
    Nature; 1992 Dec; 360(6405):672-4. PubMed ID: 1465129
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
    Yan R; Bienkowski MJ; Shuck ME; Miao H; Tory MC; Pauley AM; Brashier JR; Stratman NC; Mathews WR; Buhl AE; Carter DB; Tomasselli AG; Parodi LA; Heinrikson RL; Gurney ME
    Nature; 1999 Dec; 402(6761):533-7. PubMed ID: 10591213
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Intracellular generation of amyloid beta-protein from amyloid beta-protein precursor fragment by direct cleavage with beta- and gamma-secretase.
    Iizuka T; Shoji M; Kawarabayashi T; Sato M; Kobayashi T; Tada N; Kasai K; Matsubara E; Watanabe M; Tomidokoro Y; Hirai S
    Biochem Biophys Res Commun; 1996 Jan; 218(1):238-42. PubMed ID: 8573139
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Effects of the M1 agonist xanomeline on processing of human beta-amyloid precursor protein (FAD, Swedish mutant) transfected into Chinese hamster ovary-m1 cells.
    DeLapp N; Wu S; Belagaje R; Johnstone E; Little S; Shannon H; Bymaster F; Calligaro D; Mitch C; Whitesitt C; Ward J; Sheardown M; Fink-Jensen A; Jeppesen L; Thomsen C; Sauerberg P
    Biochem Biophys Res Commun; 1998 Mar; 244(1):156-60. PubMed ID: 9514902
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
    Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Production of Alzheimer 4kDa beta-amyloid peptide requires the C-terminal cytosolic domain of the amyloid precursor protein.
    LeBlanc AC; Gambetti P
    Biochem Biophys Res Commun; 1994 Nov; 204(3):1371-80. PubMed ID: 7980616
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Altered cleavage and secretion of a recombinant beta-APP bearing the Swedish familial Alzheimer's disease mutation.
    Felsenstein KM; Hunihan LW; Roberts SB
    Nat Genet; 1994 Mar; 6(3):251-5. PubMed ID: 8012386
    [TBL] [Abstract][Full Text] [Related]  

  • 9. BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.
    Farzan M; Schnitzler CE; Vasilieva N; Leung D; Choe H
    Proc Natl Acad Sci U S A; 2000 Aug; 97(17):9712-7. PubMed ID: 10931940
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein.
    Nunan J; Williamson NA; Hill AF; Sernee MF; Masters CL; Small DH
    J Neurosci Res; 2003 Nov; 74(3):378-85. PubMed ID: 14598314
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Down-regulation amyloid beta-protein 42 production by interfering with transcript of presenilin 1 gene with siRNA.
    Luo HM; Deng H; Xiao F; Gao Q; Weng W; Zhang PF; Li XG
    Acta Pharmacol Sin; 2004 Dec; 25(12):1613-8. PubMed ID: 15569405
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The amyloid peptide precursor in Alzheimer's disease.
    Octave JN
    Acta Neurol Belg; 1995 Dec; 95(4):197-209. PubMed ID: 8553793
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion.
    Borchardt T; Camakaris J; Cappai R; Masters CL; Beyreuther K; Multhaup G
    Biochem J; 1999 Dec; 344 Pt 2(Pt 2):461-7. PubMed ID: 10567229
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.
    Funamoto S; Morishima-Kawashima M; Tanimura Y; Hirotani N; Saido TC; Ihara Y
    Biochemistry; 2004 Oct; 43(42):13532-40. PubMed ID: 15491160
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
    Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M
    J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
    Esposito L; Gan L; Yu GQ; Essrich C; Mucke L
    J Neurochem; 2004 Dec; 91(6):1260-74. PubMed ID: 15584903
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Frame-shifted amyloid precursor protein found in Alzheimer's disease and Down's syndrome increases levels of secreted amyloid beta40.
    van Dijk R; Fischer DF; Sluijs JA; Sonnemans MA; Hobo B; Mercken L; Mann DM; Hol EM; van Leeuwen FW
    J Neurochem; 2004 Aug; 90(3):712-23. PubMed ID: 15255950
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms.
    Cater MA; McInnes KT; Li QX; Volitakis I; La Fontaine S; Mercer JF; Bush AI
    Biochem J; 2008 May; 412(1):141-52. PubMed ID: 18248325
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The expression and processing of human beta-amyloid peptide precursors in Saccharomyces cerevisiae: evidence for a novel endopeptidase in the yeast secretory system.
    Hines V; Zhang W; Ramakrishna N; Styles J; Mehta P; Kim KS; Innis M; Miller DL
    Cell Mol Biol Res; 1994; 40(4):273-84. PubMed ID: 7866429
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease.
    Mohmmad Abdul H; Sultana R; Keller JN; St Clair DK; Markesbery WR; Butterfield DA
    J Neurochem; 2006 Mar; 96(5):1322-35. PubMed ID: 16478525
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.