608 related articles for article (PubMed ID: 8621007)
1. A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of beta-cell dysfunction in the obese diabetic db/db mouse.
Zhou YP; Berggren PO; Grill V
Diabetes; 1996 May; 45(5):580-6. PubMed ID: 8621007
[TBL] [Abstract][Full Text] [Related]
2. Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans.
Zhou YP; Grill V
J Clin Endocrinol Metab; 1995 May; 80(5):1584-90. PubMed ID: 7745004
[TBL] [Abstract][Full Text] [Related]
3. Deficiency of pyruvate dehydrogenase activity in pancreatic islets of diabetic GK rats.
Zhou YP; Ostenson CG; Ling ZC; Grill V
Endocrinology; 1995 Aug; 136(8):3546-51. PubMed ID: 7628391
[TBL] [Abstract][Full Text] [Related]
4. Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle.
Zhou YP; Grill VE
J Clin Invest; 1994 Feb; 93(2):870-6. PubMed ID: 8113418
[TBL] [Abstract][Full Text] [Related]
5. A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation.
Sako Y; Grill VE
Endocrinology; 1990 Oct; 127(4):1580-9. PubMed ID: 1698143
[TBL] [Abstract][Full Text] [Related]
6. The effects of the inhibition of fatty acid oxidation on pyruvate dehydrogenase complex activity in tissues of lean and obese mice.
Bryson JM; Cooney GJ; Wensley VR; Phuyal JL; Caterson ID
Int J Obes Relat Metab Disord; 1996 Aug; 20(8):738-44. PubMed ID: 8856397
[TBL] [Abstract][Full Text] [Related]
7. Palmitate-induced beta-cell insensitivity to glucose is coupled to decreased pyruvate dehydrogenase activity and enhanced kinase activity in rat pancreatic islets.
Zhou YP; Grill VE
Diabetes; 1995 Apr; 44(4):394-9. PubMed ID: 7698506
[TBL] [Abstract][Full Text] [Related]
8. Fasting and decreased B cell sensitivity: important role for fatty acid-induced inhibition of PDH activity.
Zhou YP; Priestman DA; Randle PJ; Grill VE
Am J Physiol; 1996 Jun; 270(6 Pt 1):E988-94. PubMed ID: 8764183
[TBL] [Abstract][Full Text] [Related]
9. Inhibitory effects of fatty acids on glucose-regulated B-cell function: association with increased islet triglyceride stores and altered effect of fatty acid oxidation on glucose metabolism.
Zhou YP; Ling ZC; Grill VE
Metabolism; 1996 Aug; 45(8):981-6. PubMed ID: 8769356
[TBL] [Abstract][Full Text] [Related]
10. Glucose-fatty acid cycle to inhibit glucose utilization and oxidation is not operative in fatty acid-cultured islets.
Liu YQ; Tornheim K; Leahy JL
Diabetes; 1999 Sep; 48(9):1747-53. PubMed ID: 10480604
[TBL] [Abstract][Full Text] [Related]
11. Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition.
Patanè G; Anello M; Piro S; Vigneri R; Purrello F; Rabuazzo AM
Diabetes; 2002 Sep; 51(9):2749-56. PubMed ID: 12196468
[TBL] [Abstract][Full Text] [Related]
12. Chronic high glucose lowers pyruvate dehydrogenase activity in islets through enhanced production of long chain acyl-CoA: prevention of impaired glucose oxidation by enhanced pyruvate recycling through the malate-pyruvate shuttle.
Liu YQ; Moibi JA; Leahy JL
J Biol Chem; 2004 Feb; 279(9):7470-5. PubMed ID: 14660628
[TBL] [Abstract][Full Text] [Related]
13. Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells.
Patanè G; Piro S; Rabuazzo AM; Anello M; Vigneri R; Purrello F
Diabetes; 2000 May; 49(5):735-40. PubMed ID: 10905481
[TBL] [Abstract][Full Text] [Related]
14. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.
Unger RH
Diabetes; 1995 Aug; 44(8):863-70. PubMed ID: 7621989
[TBL] [Abstract][Full Text] [Related]
15. Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretion.
Rubí B; Antinozzi PA; Herrero L; Ishihara H; Asins G; Serra D; Wollheim CB; Maechler P; Hegardt FG
Biochem J; 2002 May; 364(Pt 1):219-26. PubMed ID: 11988095
[TBL] [Abstract][Full Text] [Related]
16. Basal insulin hypersecretion in insulin-resistant Zucker diabetic and Zucker fatty rats: role of enhanced fuel metabolism.
Zhou YP; Cockburn BN; Pugh W; Polonsky KS
Metabolism; 1999 Jul; 48(7):857-64. PubMed ID: 10421226
[TBL] [Abstract][Full Text] [Related]
17. TPN-evoked dysfunction of islet lysosomal activity mediates impairment of glucose-stimulated insulin release.
Salehi A; Fan BG; Ekelund M; Nordin G; Lundquist I
Am J Physiol Endocrinol Metab; 2001 Jul; 281(1):E171-9. PubMed ID: 11404235
[TBL] [Abstract][Full Text] [Related]
18. Co-administration of etomoxir and RU-486 mitigates insulin resistance in hepatic and muscular tissues of STZ-induced diabetic rats.
Bitar MS
Horm Metab Res; 2001 Oct; 33(10):577-84. PubMed ID: 11607876
[TBL] [Abstract][Full Text] [Related]
19. Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans.
Bensellam M; Shi YC; Chan JY; Laybutt DR; Chae H; Abou-Samra M; Pappas EG; Thomas HE; Gilon P; Jonas JC
Diabetologia; 2019 Dec; 62(12):2273-2286. PubMed ID: 31624901
[TBL] [Abstract][Full Text] [Related]
20. Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.
Cnop M; Hannaert JC; Hoorens A; Eizirik DL; Pipeleers DG
Diabetes; 2001 Aug; 50(8):1771-7. PubMed ID: 11473037
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
