139 related articles for article (PubMed ID: 8630090)
1. Inhibition of squalene synthase in vitro by 3-(biphenyl-4-yl)-quinuclidine.
Ward WH; Holdgate GA; Freeman S; McTaggart F; Girdwood PA; Davidson RG; Mallion KB; Brown GR; Eakin MA
Biochem Pharmacol; 1996 Jun; 51(11):1489-501. PubMed ID: 8630090
[TBL] [Abstract][Full Text] [Related]
2. Inhibition of squalene synthase of rat liver by novel 3' substituted quinuclidines.
McTaggart F; Brown GR; Davidson RG; Freeman S; Holdgate GA; Mallion KB; Mirrlees DJ; Smith GJ; Ward WH
Biochem Pharmacol; 1996 Jun; 51(11):1477-87. PubMed ID: 8630089
[TBL] [Abstract][Full Text] [Related]
3. Squalene synthase as a chemotherapeutic target in Trypanosoma cruzi and Leishmania mexicana.
Urbina JA; Concepcion JL; Rangel S; Visbal G; Lira R
Mol Biochem Parasitol; 2002; 125(1-2):35-45. PubMed ID: 12467972
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors.
Brown GR; Clarke DS; Foubister AJ; Freeman S; Harrison PJ; Johnson MC; Mallion KB; McCormick J; McTaggart F; Reid AC; Smith GJ; Taylor MJ
J Med Chem; 1996 Jul; 39(15):2971-9. PubMed ID: 8709131
[TBL] [Abstract][Full Text] [Related]
5. Syntheses and biological evaluation of novel quinuclidine derivatives as squalene synthase inhibitors.
Ishihara T; Kakuta H; Moritani H; Ugawa T; Sakamoto S; Tsukamoto S; Yanagisawa I
Bioorg Med Chem; 2003 May; 11(11):2403-14. PubMed ID: 12735986
[TBL] [Abstract][Full Text] [Related]
6. Inhibition of mammalian squalene synthetase activity by zaragozic acid A is a result of competitive inhibition followed by mechanism-based irreversible inactivation.
Lindsey S; Harwood HJ
J Biol Chem; 1995 Apr; 270(16):9083-96. PubMed ID: 7721822
[TBL] [Abstract][Full Text] [Related]
7. 3-(4-chlorophenyl)-2-(4-diethylaminoethoxyphenyl)-A-pentenonitrile monohydrogen citrate and related analogs. Reversible, competitive, first half-reaction squalene synthetase inhibitors.
Harwood HJ; Barbacci-Tobin EG; Petras SF; Lindsey S; Pellarin LD
Biochem Pharmacol; 1997 Mar; 53(6):839-64. PubMed ID: 9113105
[TBL] [Abstract][Full Text] [Related]
8. Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives.
Sealey-Cardona M; Cammerer S; Jones S; Ruiz-Pérez LM; Brun R; Gilbert IH; Urbina JA; González-Pacanowska D
Antimicrob Agents Chemother; 2007 Jun; 51(6):2123-9. PubMed ID: 17371809
[TBL] [Abstract][Full Text] [Related]
9. Antiproliferative and ultrastructural effects of BPQ-OH, a specific inhibitor of squalene synthase, on Leishmania amazonensis.
Rodrigues JC; Urbina JA; de Souza W
Exp Parasitol; 2005 Dec; 111(4):230-8. PubMed ID: 16198340
[TBL] [Abstract][Full Text] [Related]
10. RPR 107393, a potent squalene synthase inhibitor and orally effective cholesterol-lowering agent: comparison with inhibitors of HMG-CoA reductase.
Amin D; Rutledge RZ; Needle SN; Galczenski HF; Neuenschwander K; Scotese AC; Maguire MP; Bush RC; Hele DJ; Bilder GE; Perrone MH
J Pharmacol Exp Ther; 1997 May; 281(2):746-52. PubMed ID: 9152381
[TBL] [Abstract][Full Text] [Related]
11. In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi.
Urbina JA; Concepcion JL; Caldera A; Payares G; Sanoja C; Otomo T; Hiyoshi H
Antimicrob Agents Chemother; 2004 Jul; 48(7):2379-87. PubMed ID: 15215084
[TBL] [Abstract][Full Text] [Related]
12. The squalestatins: decarboxy and 4-deoxy analogues as potent squalene synthase inhibitors.
Chan C; Andreotti D; Cox B; Dymock BW; Hutson JL; Keeling SE; McCarthy AD; Procopiou PA; Ross BC; Sareen M; Scicinski JJ; Sharratt PJ; Snowden MA; Watson NS
J Med Chem; 1996 Jan; 39(1):207-16. PubMed ID: 8568810
[TBL] [Abstract][Full Text] [Related]
13. Squalene synthase as a target for Chagas disease therapeutics.
Shang N; Li Q; Ko TP; Chan HC; Li J; Zheng Y; Huang CH; Ren F; Chen CC; Zhu Z; Galizzi M; Li ZH; Rodrigues-Poveda CA; Gonzalez-Pacanowska D; Veiga-Santos P; de Carvalho TM; de Souza W; Urbina JA; Wang AH; Docampo R; Li K; Liu YL; Oldfield E; Guo RT
PLoS Pathog; 2014 May; 10(5):e1004114. PubMed ID: 24789335
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and biological evaluation of quinuclidine derivatives incorporating phenothiazine moieties as squalene synthase inhibitors.
Ishihara T; Kakuta H; Moritani H; Ugawa T; Yanagisawa I
Chem Pharm Bull (Tokyo); 2004 Oct; 52(10):1204-9. PubMed ID: 15467236
[TBL] [Abstract][Full Text] [Related]
15. Inhibition of squalene synthase and squalene epoxidase in tobacco cells triggers an up-regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase.
Wentzinger LF; Bach TJ; Hartmann MA
Plant Physiol; 2002 Sep; 130(1):334-46. PubMed ID: 12226513
[TBL] [Abstract][Full Text] [Related]
16. Characterization of two distinct allyl pyrophosphatase activities from rat liver microsomes.
Bansal VS; Vaidya S
Arch Biochem Biophys; 1994 Dec; 315(2):393-9. PubMed ID: 7986083
[TBL] [Abstract][Full Text] [Related]
17. A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro.
Wasko BM; Smits JP; Shull LW; Wiemer DF; Hohl RJ
J Lipid Res; 2011 Nov; 52(11):1957-64. PubMed ID: 21903868
[TBL] [Abstract][Full Text] [Related]
18. Mechanism of inhibition of yeast squalene synthase by substrate analog inhibitors.
Kalinowski SS; Mookhtiar KA
Arch Biochem Biophys; 1999 Aug; 368(2):338-46. PubMed ID: 10441385
[TBL] [Abstract][Full Text] [Related]
19. Protein farnesyltransferase: measurement of enzymatic activity in 96-well format using TopCount microplate scintillation counting technology.
Harwood HJ
Anal Biochem; 1995 Apr; 226(2):268-78. PubMed ID: 7793628
[TBL] [Abstract][Full Text] [Related]
20. Effects of squalene synthase inhibitors on the growth and ultrastructure of Trypanosoma cruzi.
Braga MV; Urbina JA; de Souza W
Int J Antimicrob Agents; 2004 Jul; 24(1):72-8. PubMed ID: 15225865
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
