BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

57 related articles for article (PubMed ID: 8632419)

  • 1. Azole endothelin antagonists. 1. A receptor model explains an unusual structure-activity profile.
    von Geldern TW; Hutchins C; Kester JA; Wu-Wong JR; Chiou W; Dixon DB; Opgenorth TJ
    J Med Chem; 1996 Feb; 39(4):957-67. PubMed ID: 8632419
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Azole endothelin antagonists. 2. Structure-activity studies.
    von Geldern TW; Kester JA; Bal R; Wu-Wong JR; Chiou W; Dixon DB; Opgenorth TJ
    J Med Chem; 1996 Feb; 39(4):968-81. PubMed ID: 8632420
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Azole endothelin antagonists. 3. Using delta log P as a tool to improve absorption.
    von Geldern TW; Hoffman DJ; Kester JA; Nellans HN; Dayton BD; Calzadilla SV; Marsh KC; Hernandez L; Chiou W; Dixon DB; Wu-Wong JR; Opgenorth TJ
    J Med Chem; 1996 Feb; 39(4):982-91. PubMed ID: 8632421
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design of a potent combined pseudopeptide endothelin-A/endothelin-B receptor antagonist, Ac-DBhg16-Leu-Asp-Ile-[NMe]Ile-Trp21 (PD 156252): examination of its pharmacokinetic and spectral properties.
    Cody WL; He JX; Reily MD; Haleen SJ; Walker DM; Reyner EL; Stewart BH; Doherty AM
    J Med Chem; 1997 Jul; 40(14):2228-40. PubMed ID: 9216842
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists.
    Riechers H; Albrecht HP; Amberg W; Baumann E; Bernard H; Böhm HJ; Klinge D; Kling A; Müller S; Raschack M; Unger L; Walker N; Wernet W
    J Med Chem; 1996 May; 39(11):2123-8. PubMed ID: 8667356
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Potent and selective non-benzodioxole-containing endothelin-A receptor antagonists.
    Tasker AS; Sorensen BK; Jae HS; Winn M; von Geldern TW; Dixon DB; Chiou WJ; Dayton BD; Calzadila S; Hernandez L; Marsh KC; WuWong JR; Opgenorth TJ
    J Med Chem; 1997 Jan; 40(3):322-30. PubMed ID: 9022798
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-activity relationships of N2-aryl-3-(isoxazolylsulfamoyl)-2-thiophenecarboxamides as selective endothelin receptor-A antagonists.
    Wu C; Chan MF; Stavros F; Raju B; Okun I; Castillo RS
    J Med Chem; 1997 May; 40(11):1682-9. PubMed ID: 9171877
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Selective endothelin A receptor antagonists. 3. Discovery and structure-activity relationships of a series of 4-phenoxybutanoic acid derivatives.
    Astles PC; Brealey C; Brown TJ; Facchini V; Handscombe C; Harris NV; McCarthy C; McLay IM; Porter B; Roach AG; Sargent C; Smith C; Walsh RJ
    J Med Chem; 1998 Jul; 41(15):2732-44. PubMed ID: 9667964
    [TBL] [Abstract][Full Text] [Related]  

  • 9. New non-peptide endothelin-A receptor antagonists: synthesis, biological properties, and structure-activity relationships of 5-(dimethylamino)-N-pyridyl-,-N-pyrimidinyl-,-N-pyridazinyl-, and -N-pyrazinyl-1-naphthalenesulfonamides.
    Bradbury RH; Bath C; Butlin RJ; Dennis M; Heys C; Hunt SJ; James R; Mortlock AA; Sumner NF; Tang EK; Telford B; Whiting E; Wilson C
    J Med Chem; 1997 Mar; 40(6):996-1004. PubMed ID: 9083490
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 2,4-Diarylpyrrolidine-3-carboxylic acids--potent ETA selective endothelin receptor antagonists. 1. Discovery of A-127722.
    Winn M; von Geldern TW; Opgenorth TJ; Jae HS; Tasker AS; Boyd SA; Kester JA; Mantei RA; Bal R; Sorensen BK; Wu-Wong JR; Chiou WJ; Dixon DB; Novosad EI; Hernandez L; Marsh KC
    J Med Chem; 1996 Mar; 39(5):1039-48. PubMed ID: 8676339
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Chiral pyrrolo[2,3-d]pyrimidine and pyrimido[4,5-b]indole derivatives: structure-activity relationships of potent, highly stereoselective A1-adenosine receptor antagonists.
    Müller CE; Geis U; Grahner B; Lanzner W; Eger K
    J Med Chem; 1996 Jun; 39(13):2482-91. PubMed ID: 8691445
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Pyrrolidine-3-carboxylic acids as endothelin antagonists. 2. Sulfonamide-based ETA/ETB mixed antagonists.
    Jae HS; Winn M; Dixon DB; Marsh KC; Nguyen B; Opgenorth TJ; von Geldern TW
    J Med Chem; 1997 Sep; 40(20):3217-27. PubMed ID: 9379441
    [TBL] [Abstract][Full Text] [Related]  

  • 13. (+/-)-3-[4'-(N,N-dimethylamino)cinnamyl]benzazepine analogs: novel dopamine D1 receptor antagonists.
    Shah JH; Kline RH; Geter-Douglass B; Izenwasser S; Witkin JM; Newman AH
    J Med Chem; 1996 Aug; 39(17):3423-8. PubMed ID: 8765528
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design, synthesis, and activity of a series of pyrrolidine-3-carboxylic acid-based, highly specific, orally active ET(B) antagonists containing a diphenylmethylamine acetamide side chain.
    Liu G; Kozmina NS; Winn M; von Geldern TW; Chiou WJ; Dixon DB; Nguyen B; Marsh KC; Opgenorth TJ
    J Med Chem; 1999 Sep; 42(18):3679-89. PubMed ID: 10479299
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pharmacological profile of ZD1611, a novel, orally active endothelin ETA receptor antagonist.
    Wilson C; Hunt SJ; Tang E; Wright N; Kelly E; Palmer S; Heys C; Mellor S; James R; Bialecki R
    J Pharmacol Exp Ther; 1999 Sep; 290(3):1085-91. PubMed ID: 10454481
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and serotonergic activity of substituted 2, N-benzylcarboxamido-5-(2-ethyl-1-dioxoimidazolidinyl)-N, N-dimethyltryptamine derivatives: novel antagonists for the vascular 5-HT(1B)-like receptor.
    Moloney GP; Martin GR; Mathews N; Milne A; Hobbs H; Dodsworth S; Sang PY; Knight C; Williams M; Maxwell M; Glen RC
    J Med Chem; 1999 Jul; 42(14):2504-26. PubMed ID: 10411472
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design, syntheses, and structure-activity relationships of indan derivatives as endothelin antagonists; new lead generation of non-peptidic antagonist from peptidic leads.
    Morimoto H; Fukushima C; Yamauchi R; Hosino T; Kikkawa K; Yasuda K; Yamada K
    Bioorg Med Chem; 2001 Feb; 9(2):255-68. PubMed ID: 11249118
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A structure-activity study of a C-terminal endothelin analogue.
    Cassano E; Galoppini C; Giusti L; Hamdan M; Macchia M; Mazzoni MR; Menchini E; Pegoraro S; Rovero P
    Folia Biol (Praha); 1998; 44(1):11-4. PubMed ID: 10730869
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Chemical function based pharmacophore generation of endothelin-A selective receptor antagonists.
    Funk OF; Kettmann V; Drimal J; Langer T
    J Med Chem; 2004 May; 47(11):2750-60. PubMed ID: 15139753
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification of novel short chain 4-substituted indoles as potent alphavbeta3 antagonist using structure-based drug design.
    Raboisson P; Desjarlais RL; Reed R; Lattanze J; Chaikin M; Manthey CL; Tomczuk BE; Marugán JJ
    Eur J Med Chem; 2007 Mar; 42(3):334-43. PubMed ID: 17184884
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 3.