BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

161 related articles for article (PubMed ID: 8634824)

  • 1. 1,2,9,9a-Tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogs of CC-1065 and the duocarmycins: synthesis and evaluation.
    Boger DL; Yun W; Han N
    Bioorg Med Chem; 1995 Nov; 3(11):1429-53. PubMed ID: 8634824
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Evaluation of functional analogs of CC-1065 and the duocarmycins incorporating the cross-linking 9a-chloromethyl-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-on e (C2BI) alkylation subunit.
    Boger DL; Johnson DS; Palanki MS; Kitos PA; Chang J; Dowell P
    Bioorg Med Chem; 1993 Jul; 1(1):27-38. PubMed ID: 8081835
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa.
    Boger DL; Hughes TV; Hedrick MP
    J Org Chem; 2001 Apr; 66(7):2207-16. PubMed ID: 11281757
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Parallel synthesis and evaluation of 132 (+)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogues of CC-1065 and the duocarmycins defining the contribution of the DNA-binding domain.
    Boger DL; Schmitt HW; Fink BE; Hedrick MP
    J Org Chem; 2001 Oct; 66(20):6654-61. PubMed ID: 11578217
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Substituent effects within the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.
    Boger DL; Stauffer F; Hedrick MP
    Bioorg Med Chem Lett; 2001 Aug; 11(15):2021-4. PubMed ID: 11454471
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and evaluation of 1,2,8, 8a-Tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one, the parent alkylation subunit of CC-1065 and the duocarmycins: impact of the alkylation subunit substituents and its implications for DNA alkylation catalysis.
    Boger DL; Santillán A; Searcey M; Brunette SR; Wolkenberg SE; Hedrick MP; Jin Q
    J Org Chem; 2000 Jun; 65(13):4101-11. PubMed ID: 10866627
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and evaluation of a series of C3-substituted CBI analogues of CC-1065 and the duocarmycins.
    Boger DL; Brunette SR; Garbaccio RM
    J Org Chem; 2001 Jul; 66(15):5163-73. PubMed ID: 11463270
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and Properties of Substituted CBI Analogs of CC-1065 and the Duocarmycins Incorporating the 7-Methoxy-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (MCBI) Alkylation Subunit: Magnitude of Electronic Effects on the Functional Reactivity.
    Boger DL; McKie JA; Cai H; Cacciari B; Baraldi PG
    J Org Chem; 1996 Mar; 61(5):1710-1729. PubMed ID: 11667041
    [TBL] [Abstract][Full Text] [Related]  

  • 9. CBI-CDPBO1 and CBI-CDPBI1: CC-1065 analogs containing deep-seated modifications in the DNA binding subunit.
    Boger DL; Yun W; Cai H; Han N
    Bioorg Med Chem; 1995 Jun; 3(6):761-7. PubMed ID: 7582954
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and evaluation of duocarmycin and CC-1065 analogues incorporating the 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]-3-azaindol-4-one (CBA) alkylation subunit.
    Parrish JP; Kastrinsky DB; Hwang I; Boger DL
    J Org Chem; 2003 Nov; 68(23):8984-90. PubMed ID: 14604371
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and biochemical evaluation of the CBI-PDE-I-dimer, a benzannelated analog of (+)-CC-1065 that also produces delayed toxicity in mice.
    Aristoff PA; Johnson PD; Sun D; Hurley LH
    J Med Chem; 1993 Jul; 36(14):1956-63. PubMed ID: 8336335
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins.
    Tichenor MS; MacMillan KS; Stover JS; Wolkenberg SE; Pavani MG; Zanella L; Zaid AN; Spalluto G; Rayl TJ; Hwang I; Baraldi PG; Boger DL
    J Am Chem Soc; 2007 Nov; 129(45):14092-9. PubMed ID: 17948994
    [TBL] [Abstract][Full Text] [Related]  

  • 13. CC-1065/duocarmycin and bleomycin A2 hybrid agents: lack of enhancement of DNA alkylation by attachment to noncomplementary DNA binding subunits.
    Boger DL; Han N
    Bioorg Med Chem; 1997 Feb; 5(2):233-43. PubMed ID: 9061188
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Establishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.
    Parrish JP; Kastrinsky DB; Stauffer F; Hedrick MP; Hwang I; Boger DL
    Bioorg Med Chem; 2003 Aug; 11(17):3815-38. PubMed ID: 12901927
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Selective metal cation activation of a DNA alkylating agent: synthesis and evaluation of methyl 1,2,9, 9a-Tetrahydrocyclopropa[c]pyrido[3,2-e]indol-4-one-7-carboxylate (CPyI).
    Boger DL; Boyce CW
    J Org Chem; 2000 Jun; 65(13):4088-100. PubMed ID: 10866626
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Effective asymmetric synthesis of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI).
    Kastrinsky DB; Boger DL
    J Org Chem; 2004 Apr; 69(7):2284-9. PubMed ID: 15049620
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Demonstration of a pronounced effect of noncovalent binding selectivity on the (+)-CC-1065 DNA alkylation and identification of the pharmacophore of the alkylation subunit.
    Boger DL; Zarrinmayeh H; Munk SA; Kitos PA; Suntornwat O
    Proc Natl Acad Sci U S A; 1991 Feb; 88(4):1431-5. PubMed ID: 1847523
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Asymmetric synthesis of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI).
    Lajiness JP; Boger DL
    J Org Chem; 2011 Jan; 76(2):583-7. PubMed ID: 21192653
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Molecular basis for sequence selective DNA alkylation by (+)- and ent-(-)-CC-1065 and related agents: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity.
    Boger DL; Johnson DS; Yun W; Tarby CM
    Bioorg Med Chem; 1994 Feb; 2(2):115-35. PubMed ID: 7922122
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit.
    Boyle KE; MacMillan KS; Ellis DA; Lajiness JP; Robertson WM; Boger DL
    Bioorg Med Chem Lett; 2010 Mar; 20(6):1854-7. PubMed ID: 20171886
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.