These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

88 related articles for article (PubMed ID: 8648603)

  • 21. SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction.
    Pissarnitski DA; Asberom T; Boyle CD; Chackalamannil S; Chintala M; Clader JW; Greenlee WJ; Hu Y; Kurowski S; Myers J; Palamanda J; Stamford AW; Vemulapalli S; Wang Y; Wang P; Wu P; Xu R
    Bioorg Med Chem Lett; 2004 Mar; 14(5):1291-4. PubMed ID: 14980684
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Synthesis, analgesic, anti-inflammatory, ulcerogenic index and antibacterial activities of novel 2-methylthio-3-substituted-5,6,7,8-tetrahydrobenzo (b) thieno[2,3-d]pyrimidin-4(3H)-ones.
    Alagarsamy V; Meena S; Ramseshu KV; Solomon VR; Thirumurugan K; Dhanabal K; Murugan M
    Eur J Med Chem; 2006 Nov; 41(11):1293-300. PubMed ID: 16928409
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Dibenzoquinazoline diones as antihypertensive cyclic guanosine monophosphate phosphodiesterase inhibitors.
    Booth RF; Buckham SP; Lunt DO; Manley PW; Porter RA
    Biochem Pharmacol; 1987 Oct; 36(20):3517-21. PubMed ID: 2823824
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Synthesis and 3 alpha-hydroxysteroid dehydrogenase inhibitory activity of some N(6)-(pyrazol-5-yl)-pyr-azolo[4,3-d]pyrimidin-7-ones.
    Migliara O; Plescia S; Schillaci D
    Pharmazie; 1996 Dec; 51(12):983-4. PubMed ID: 8985986
    [No Abstract]   [Full Text] [Related]  

  • 25. Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase 5 (PDE5) inhibitory activity as potential agents for treatment of erectile dysfunction.
    Giovannoni MP; Vergelli C; Biancalani C; Cesari N; Graziano A; Biagini P; Gracia J; Gavaldà A; Dal Piaz V
    J Med Chem; 2006 Aug; 49(17):5363-71. PubMed ID: 16913726
    [TBL] [Abstract][Full Text] [Related]  

  • 26. The cyclic GMP-specific phosphodiesterase inhibitor, sildenafil, stimulates human sperm motility and capacitation but not acrosome reaction.
    Lefièvre L; De Lamirande E; Gagnon C
    J Androl; 2000; 21(6):929-37. PubMed ID: 11105920
    [TBL] [Abstract][Full Text] [Related]  

  • 27. [Derivatives of pyrimidine 1,2-condensate. IV. Synthesis and pharmacological properties of the N,N-disubstituted 4-amino-2H-pyrido(1,2-a)pyrimidin- 2-ones and 2-amino-4H-pyrido(1,2-a)pyrmidin-4-ones].
    Di Braccio M; Roma G; Mazzei M; Balbi A; Schiantarelli P; Cadel S; Bongrani S
    Farmaco Sci; 1988 Sep; 43(9):705-23. PubMed ID: 3229496
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Discovery of 2-(cyclopentylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as a new series of potent phosphodiesterase 7 inhibitors.
    Kawai K; Endo Y; Asano T; Amano S; Sawada K; Ueo N; Takahashi N; Sonoda Y; Nagai M; Kamei N; Nagata N
    J Med Chem; 2014 Dec; 57(23):9844-54. PubMed ID: 25383422
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity.
    Devadas B; Freeman SK; Zupec ME; Lu HF; Nagarajan SR; Kishore NS; Lodge JK; Kuneman DW; McWherter CA; Vinjamoori DV; Getman DP; Gordon JI; Sikorski JA
    J Med Chem; 1997 Aug; 40(16):2609-25. PubMed ID: 9258368
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Novel lopinavir analogues incorporating heterocyclic replacements of six-member cyclic urea--synthesis and structure-activity relationships.
    Sham HL; Betebenner DA; Rosenbrook W; Herrin T; Saldivar A; Vasavanonda S; Plattner JJ; Norbeck DW
    Bioorg Med Chem Lett; 2004 May; 14(10):2643-5. PubMed ID: 15109669
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Comparison of different heterocyclic scaffolds as substrate analog PDE5 inhibitors.
    Haning H; Niewöhner U; Schenke T; Lampe T; Hillisch A; Bischoff E
    Bioorg Med Chem Lett; 2005 Sep; 15(17):3900-7. PubMed ID: 15993055
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Inhibition of cGMP-phosphodiesterase-5 by biflavones of Ginkgo biloba.
    Dell'Agli M; Galli GV; Bosisio E
    Planta Med; 2006 Apr; 72(5):468-70. PubMed ID: 16557462
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Furoyl and benzofuroyl pyrroloquinolones as potent and selective PDE5 inhibitors for treatment of erectile dysfunction.
    Jiang W; Sui Z; Macielag MJ; Walsh SP; Fiordeliso JJ; Lanter JC; Guan J; Qiu Y; Kraft P; Bhattacharjee S; Craig E; Haynes-Johnson D; John TM; Clancy J
    J Med Chem; 2003 Jan; 46(3):441-4. PubMed ID: 12540243
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Synthesis of 2-mercapto-3-substituted-5,6-dimethylthieno[2,3-d] pyrimidin-4(3H)-ones as new analgesic, anti-inflammatory agents.
    Alagarsamy V; Vijayakumar S; Raja Solomon V
    Biomed Pharmacother; 2007 Jun; 61(5):285-91. PubMed ID: 17391907
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Inhibitors of acyl-CoA:cholesterol O-acyltransferase. synthesis and pharmacological activity of (+/-)-2-dodecyl-alpha-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5- acetamide and structurally related tetrazole amide derivatives.
    O'Brien PM; Sliskovic DR; Picard JA; Lee HT; Purchase CF; Roth BD; White AD; Anderson M; Mueller SB; Bocan T; Bousley R; Hamelehle KL; Homan R; Lee P; Krause BR; Reindel JF; Stanfield RL; Turluck D
    J Med Chem; 1996 Jun; 39(12):2354-66. PubMed ID: 8691430
    [TBL] [Abstract][Full Text] [Related]  

  • 36. The role of phosphodiesterase isoforms 2, 5, and 9 in the regulation of NO-dependent and NO-independent cGMP production in the rat cervical spinal cord.
    de Vente J; Markerink-van Ittersum M; Vles JS
    J Chem Neuroanat; 2006 Jun; 31(4):275-303. PubMed ID: 16621445
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Development of 2-t butyl-N-methyl pyrimidones as potent inhibitors of HIV integrase.
    Di Francesco ME; Pace P; Fiore F; Naimo F; Bonelli F; Rowley M; Summa V
    Bioorg Med Chem Lett; 2008 Apr; 18(8):2709-13. PubMed ID: 18362069
    [TBL] [Abstract][Full Text] [Related]  

  • 38. New pyrrolopyrimidin-6-yl benzenesulfonamides: potent A2B adenosine receptor antagonists.
    Esteve C; Nueda A; Díaz JL; Beleta J; Cárdenas A; Lozoya E; Cadavid MI; Loza MI; Ryder H; Vidal B
    Bioorg Med Chem Lett; 2006 Jul; 16(14):3642-5. PubMed ID: 16697192
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships.
    Ko WC; Shih CM; Lai YH; Chen JH; Huang HL
    Biochem Pharmacol; 2004 Nov; 68(10):2087-94. PubMed ID: 15476679
    [TBL] [Abstract][Full Text] [Related]  

  • 40. A 46-amino acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization.
    Blount MA; Zoraghi R; Ke H; Bessay EP; Corbin JD; Francis SH
    Mol Pharmacol; 2006 Nov; 70(5):1822-31. PubMed ID: 16926278
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 5.