These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

169 related articles for article (PubMed ID: 8652509)

  • 1. Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site.
    Loll PJ; Picot D; Ekabo O; Garavito RM
    Biochemistry; 1996 Jun; 35(23):7330-40. PubMed ID: 8652509
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Investigation of the binding of isoform-selective inhibitors to prostaglandin endoperoxide synthases using fluorescence spectroscopy.
    Lanzo CA; Beechem JM; Talley J; Marnett LJ
    Biochemistry; 1998 Jan; 37(1):217-26. PubMed ID: 9425042
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Kinetics of the interaction of nonsteroidal antiinflammatory drugs with prostaglandin endoperoxide synthase-1 studied by limited proteolysis.
    Kalgutkar AS; Crews BC; Marnett LJ
    Biochemistry; 1996 Jul; 35(28):9076-82. PubMed ID: 8703911
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents.
    Kurumbail RG; Stevens AM; Gierse JK; McDonald JJ; Stegeman RA; Pak JY; Gildehaus D; Miyashiro JM; Penning TD; Seibert K; Isakson PC; Stallings WC
    Nature; 1996 Dec 19-26; 384(6610):644-8. PubMed ID: 8967954
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1.
    Picot D; Loll PJ; Garavito RM
    Nature; 1994 Jan; 367(6460):243-9. PubMed ID: 8121489
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations.
    Selinsky BS; Gupta K; Sharkey CT; Loll PJ
    Biochemistry; 2001 May; 40(17):5172-80. PubMed ID: 11318639
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Biochemistry of prostaglandin endoperoxide H synthase-1 and synthase-2 and their differential susceptibility to nonsteroidal anti-inflammatory drugs.
    Smith WL; DeWitt DL
    Semin Nephrol; 1995 May; 15(3):179-94. PubMed ID: 7631045
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The 3.1 A X-ray crystal structure of the integral membrane enzyme prostaglandin H2 synthase-1.
    Garavito RM; Picot D; Loll PJ
    Adv Prostaglandin Thromboxane Leukot Res; 1995; 23():99-103. PubMed ID: 7732912
    [No Abstract]   [Full Text] [Related]  

  • 9. Differential inhibition of murine prostaglandin synthase-1 and -2 by nonsteroidal anti-inflammatory drugs using exogenous and endogenous sources of arachidonic acid.
    Chulada PC; Langenbach R
    J Pharmacol Exp Ther; 1997 Feb; 280(2):606-13. PubMed ID: 9023270
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The interaction of arginine 106 of human prostaglandin G/H synthase-2 with inhibitors is not a universal component of inhibition mediated by nonsteroidal anti-inflammatory drugs.
    Greig GM; Francis DA; Falgueyret JP; Ouellet M; Percival MD; Roy P; Bayly C; Mancini JA; O'Neill GP
    Mol Pharmacol; 1997 Nov; 52(5):829-38. PubMed ID: 9351974
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Involvement of arginine 120, glutamate 524, and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1.
    Bhattacharyya DK; Lecomte M; Rieke CJ; Garavito M; Smith WL
    J Biol Chem; 1996 Jan; 271(4):2179-84. PubMed ID: 8567676
    [TBL] [Abstract][Full Text] [Related]  

  • 12. O-acetylsalicylhydroxamic acid, a novel acetylating inhibitor of prostaglandin H2 synthase: structural and functional characterization of enzyme-inhibitor interactions.
    Loll PJ; Sharkey CT; O'Connor SJ; Dooley CM; O'Brien E; Devocelle M; Nolan KB; Selinsky BS; Fitzgerald DJ
    Mol Pharmacol; 2001 Dec; 60(6):1407-13. PubMed ID: 11723249
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Molecular modelling of the differential interaction between several non-steroidal anti-inflammatory drugs and human prostaglandin endoperoxide H synthase-2 (h-PGHS-2).
    Pouplana R; Lozano JJ; Ruiz J
    J Mol Graph Model; 2002 Jan; 20(4):329-43. PubMed ID: 11858641
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Identification of Tyr504 as an alternative tyrosyl radical site in human prostaglandin H synthase-2.
    Rogge CE; Liu W; Wu G; Wang LH; Kulmacz RJ; Tsai AL
    Biochemistry; 2004 Feb; 43(6):1560-8. PubMed ID: 14769032
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and evaluation of S-4-(3-thienyl)phenyl-alpha-methylacetic acid.
    Mittal S; Malde A; Selvam C; Arun KH; Johar PS; Jachak SM; Ramarao P; Bharatam PV; Chawla HP
    Bioorg Med Chem Lett; 2004 Feb; 14(4):979-82. PubMed ID: 15013005
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats.
    Schmassmann A; Peskar BM; Stettler C; Netzer P; Stroff T; Flogerzi B; Halter F
    Br J Pharmacol; 1998 Mar; 123(5):795-804. PubMed ID: 9535006
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The 2.0 A resolution crystal structure of prostaglandin H2 synthase-1: structural insights into an unusual peroxidase.
    Gupta K; Selinsky BS; Kaub CJ; Katz AK; Loll PJ
    J Mol Biol; 2004 Jan; 335(2):503-18. PubMed ID: 14672659
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Arginine 120 of prostaglandin G/H synthase-1 is required for the inhibition by nonsteroidal anti-inflammatory drugs containing a carboxylic acid moiety.
    Mancini JA; Riendeau D; Falgueyret JP; Vickers PJ; O'Neill GP
    J Biol Chem; 1995 Dec; 270(49):29372-7. PubMed ID: 7493972
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cyclooxygenase inactivation kinetics during reaction of prostaglandin H synthase-1 with peroxide.
    Wu G; Kulmacz RJ; Tsai AL
    Biochemistry; 2003 Nov; 42(46):13772-7. PubMed ID: 14622024
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Arachidonic acid and nonsteroidal anti-inflammatory drugs induce conformational changes in the human prostaglandin endoperoxide H2 synthase-2 (cyclooxygenase-2).
    Smith T; McCracken J; Shin YK; DeWitt D
    J Biol Chem; 2000 Dec; 275(51):40407-15. PubMed ID: 11006278
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.