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2. Protein phosphorylation changes ligand-binding efficiency of cytochrome P450c17 (CYP17) and accelerates its proteolytic degradation: putative relevance for hormonal regulation of CYP17 activity. Löhr JB; Kühn-Velten WN Biochem Biophys Res Commun; 1997 Feb; 231(2):403-8. PubMed ID: 9070288 [TBL] [Abstract][Full Text] [Related]
3. Improvement of cytochrome P450c17 catalytic processivity as a novel mechanism to attenuate hormonal consequences of enzyme decay in the testes after a gonadotropin surge. Kühn-Velten WN Eur J Endocrinol; 1997 Apr; 136(4):438-43. PubMed ID: 9150706 [TBL] [Abstract][Full Text] [Related]
4. Ketoconazole inhibition of the bifunctional cytochrome P450c17 does not affect androgen formation from the endogenous lyase substrate. The catalytic site remains refractory in the course of intermediary hydroxyprogesterone processing. Kühn-Velten WN; Lessmann M Biochem Pharmacol; 1992 Dec; 44(12):2371-8. PubMed ID: 1472102 [TBL] [Abstract][Full Text] [Related]
5. Inhibition of steroidogenic cytochrome P-450 enzymes in rat testis by ketoconazole and related imidazole anti-fungal drugs. Kan PB; Hirst MA; Feldman D J Steroid Biochem; 1985 Dec; 23(6A):1023-9. PubMed ID: 3841572 [TBL] [Abstract][Full Text] [Related]
6. Acute decrease by human chorionic gonadotropin of the activity of preovulatory ovarian 17 alpha-hydroxylase and C-17-C-20 lyase is due to decrease of microsomal cytochrome P-450 through de novo synthesis of ribonucleic acid and protein. Suzuki K; Tamaoki B Endocrinology; 1983 Dec; 113(6):1985-91. PubMed ID: 6196179 [TBL] [Abstract][Full Text] [Related]
8. Novel connections between NADPH-induced lipid peroxidation and cytochrome P450 inactivation, and antioxidant and enzyme protective properties of estradiol in gonadal membranes. Kühn-Velten WN; Pippirs U Free Radic Res; 1997 Feb; 26(2):125-33. PubMed ID: 9257124 [TBL] [Abstract][Full Text] [Related]
9. The role of cytochrome b5 in the biosynthesis of androgens by human P450c17. Katagiri M; Kagawa N; Waterman MR Arch Biochem Biophys; 1995 Mar; 317(2):343-7. PubMed ID: 7893148 [TBL] [Abstract][Full Text] [Related]
11. Reconstitution of steroid 17,20-lyase activity after separation and purification of cytochrome P-450 and its reductase from rat testis microsomes. Betz G; Tsai P; Hales D Endocrinology; 1980 Oct; 107(4):1055-60. PubMed ID: 6773745 [TBL] [Abstract][Full Text] [Related]
12. Molecular cloning and expression of guinea pig cytochrome P450c17 cDNA (steroid 17 alpha-hydroxylase/17,20 lyase): tissue distribution, regulation, and substrate specificity of the expressed enzyme. Tremblay Y; Fleury A; Beaudoin C; Vallée M; Bélanger A DNA Cell Biol; 1994 Dec; 13(12):1199-212. PubMed ID: 7811386 [TBL] [Abstract][Full Text] [Related]
13. Androgen formation by cytochrome P450 CYP17. Solvent isotope effect and pL studies suggest a role for protons in the regulation of oxene versus peroxide chemistry. Swinney DC; Mak AY Biochemistry; 1994 Mar; 33(8):2185-90. PubMed ID: 8117675 [TBL] [Abstract][Full Text] [Related]
14. Inhibitory effect of some imidazole antifungal compounds on the synthesis of 16-ene-C19-steroid catalyzed by pig testicular microsomes. Nakajin S; Takahashi K; Shinoda M J Steroid Biochem Mol Biol; 1991 Jan; 38(1):95-9. PubMed ID: 1997127 [TBL] [Abstract][Full Text] [Related]
16. Rapid down-regulation of testicular androgen biosynthesis at increased environmental temperature is due to cytochrome P450c17 (CYP17) thermolability in Leydig cells, but not in endoplasmic reticulum membranes. Kühn-Velten WN Exp Clin Endocrinol Diabetes; 1996; 104(3):243-9. PubMed ID: 8817242 [TBL] [Abstract][Full Text] [Related]
17. Role of cytochrome b5 in the cytochrome P-450-mediated C21-steroid 17,20-lyase reaction. Katagiri M; Suhara K; Shiroo M; Fujimura Y Biochem Biophys Res Commun; 1982 Sep; 108(1):379-84. PubMed ID: 6816231 [No Abstract] [Full Text] [Related]
18. Progesterone 16 alpha-hydroxylase activity is catalyzed by human cytochrome P450 17 alpha-hydroxylase. Swart P; Swart AC; Waterman MR; Estabrook RW; Mason JI J Clin Endocrinol Metab; 1993 Jul; 77(1):98-102. PubMed ID: 8325965 [TBL] [Abstract][Full Text] [Related]
19. Kinetic analysis of inhibition of human adrenal steroidogenesis by ketoconazole. Couch RM; Muller J; Perry YS; Winter JS J Clin Endocrinol Metab; 1987 Sep; 65(3):551-4. PubMed ID: 3497939 [TBL] [Abstract][Full Text] [Related]
20. Integration of new regulatory strategies into the network of an endocrine control system: limitation of androgen secretion by rat testis is achieved by substrate-dependent modulation of P450XVII enzyme concentration and catalytic efficiency. Kühn-Velten WN Andrologia; 1992; 24(2):109-11. PubMed ID: 1605399 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]