BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

162 related articles for article (PubMed ID: 8662733)

  • 1. Pathways downstream of Shc and Grb2 are required for cell transformation by the tpr-Met oncoprotein.
    Fixman ED; Fournier TM; Kamikura DM; Naujokas MA; Park M
    J Biol Chem; 1996 May; 271(22):13116-22. PubMed ID: 8662733
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1.
    Fixman ED; Holgado-Madruga M; Nguyen L; Kamikura DM; Fournier TM; Wong AJ; Park M
    J Biol Chem; 1997 Aug; 272(32):20167-72. PubMed ID: 9242692
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Efficient cell transformation by the Tpr-Met oncoprotein is dependent upon tyrosine 489 in the carboxy-terminus.
    Fixman ED; Naujokas MA; Rodrigues GA; Moran MF; Park M
    Oncogene; 1995 Jan; 10(2):237-49. PubMed ID: 7838524
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis.
    Saucier C; Papavasiliou V; Palazzo A; Naujokas MA; Kremer R; Park M
    Oncogene; 2002 Mar; 21(12):1800-11. PubMed ID: 11896612
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase.
    Besset V; Scott RP; Ibáñez CF
    J Biol Chem; 2000 Dec; 275(50):39159-66. PubMed ID: 10995764
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Activation of the JNK pathway is essential for transformation by the Met oncogene.
    Rodrigues GA; Park M; Schlessinger J
    EMBO J; 1997 May; 16(10):2634-45. PubMed ID: 9184210
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The tyrosines in the bidentate motif of the env-sea oncoprotein are essential for cell transformation and are binding sites for Grb2 and the tyrosine phosphatase SHP-2.
    Park CY; Hayman MJ
    J Biol Chem; 1999 Mar; 274(11):7583-90. PubMed ID: 10066827
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Neoplastic transformation induced by insulin receptor substrate-1 overexpression requires an interaction with both Grb2 and Syp signaling molecules.
    Tanaka S; Ito T; Wands JR
    J Biol Chem; 1996 Jun; 271(24):14610-6. PubMed ID: 8662827
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase.
    Welham MJ; Dechert U; Leslie KB; Jirik F; Schrader JW
    J Biol Chem; 1994 Sep; 269(38):23764-8. PubMed ID: 7522233
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Oncogenic Met receptor induces cell-cycle progression in Xenopus oocytes independent of direct Grb2 and Shc binding or Mos synthesis, but requires phosphatidylinositol 3-kinase and Raf signaling.
    Mood K; Saucier C; Ishimura A; Bong YS; Lee HS; Park M; Daar IO
    J Cell Physiol; 2006 Apr; 207(1):271-85. PubMed ID: 16331688
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A 60-kilodalton protein in rat hepatoma cells overexpressing insulin receptor was tyrosine phosphorylated and associated with Syp, phophatidylinositol 3-kinase, and Grb2 in an insulin-dependent manner.
    Zhang-Sun G; Yang C; Viallet J; Feng G; Bergeron JJ; Posner BI
    Endocrinology; 1996 Jul; 137(7):2649-58. PubMed ID: 8770882
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Characterization of a novel tyrosine phosphorylated 100-kDa protein that binds to SHP-2 and phosphatidylinositol 3'-kinase in myeloid cells.
    Carlberg K; Rohrschneider LR
    J Biol Chem; 1997 Jun; 272(25):15943-50. PubMed ID: 9188495
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation.
    Bazenet CE; Gelderloos JA; Kazlauskas A
    Mol Cell Biol; 1996 Dec; 16(12):6926-36. PubMed ID: 8943348
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Branching tubulogenesis but not scatter of madin-darby canine kidney cells requires a functional Grb2 binding site in the Met receptor tyrosine kinase.
    Fournier TM; Kamikura D; Teng K; Park M
    J Biol Chem; 1996 Sep; 271(36):22211-7. PubMed ID: 8703035
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells.
    Zhang S; Mantel C; Broxmeyer HE
    J Leukoc Biol; 1999 Mar; 65(3):372-80. PubMed ID: 10080542
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways.
    Roche S; McGlade J; Jones M; Gish GD; Pawson T; Courtneidge SA
    EMBO J; 1996 Sep; 15(18):4940-8. PubMed ID: 8890167
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Gab1 is required for cell cycle transition, cell proliferation, and transformation induced by an oncogenic met receptor.
    Mood K; Saucier C; Bong YS; Lee HS; Park M; Daar IO
    Mol Biol Cell; 2006 Sep; 17(9):3717-28. PubMed ID: 16775003
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Grb2 binding to the different isoforms of Ret tyrosine kinase.
    Alberti L; Borrello MG; Ghizzoni S; Torriti F; Rizzetti MG; Pierotti MA
    Oncogene; 1998 Sep; 17(9):1079-87. PubMed ID: 9764818
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Involvement of Src-homology-2-domain-containing protein-tyrosine phosphatase 2 in T cell activation.
    Tailor P; Jascur T; Williams S; von Willebrand M; Couture C; Mustelin T
    Eur J Biochem; 1996 May; 237(3):736-42. PubMed ID: 8647120
    [TBL] [Abstract][Full Text] [Related]  

  • 20. p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase.
    Panchamoorthy G; Fukazawa T; Miyake S; Soltoff S; Reedquist K; Druker B; Shoelson S; Cantley L; Band H
    J Biol Chem; 1996 Feb; 271(6):3187-94. PubMed ID: 8621719
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.