These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

232 related articles for article (PubMed ID: 8663121)

  • 1. A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors.
    Gierse JK; McDonald JJ; Hauser SD; Rangwala SH; Koboldt CM; Seibert K
    J Biol Chem; 1996 Jun; 271(26):15810-4. PubMed ID: 8663121
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The structure of mammalian cyclooxygenases.
    Garavito RM; Mulichak AM
    Annu Rev Biophys Biomol Struct; 2003; 32():183-206. PubMed ID: 12574066
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural basis for selective inhibition of COX-2 by nimesulide.
    Fabiola GF; Pattabhi V; Nagarajan K
    Bioorg Med Chem; 1998 Dec; 6(12):2337-44. PubMed ID: 9925294
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors.
    Kalgutkar AS; Marnett AB; Crews BC; Remmel RP; Marnett LJ
    J Med Chem; 2000 Jul; 43(15):2860-70. PubMed ID: 10956194
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structure-based QSAR study on differential inhibition of human prostaglandin endoperoxide H synthase-2 (COX-2) by nonsteroidal anti-inflammatory drugs.
    Pouplana R; Lozano JJ; Pérez C; Ruiz J
    J Comput Aided Mol Des; 2002 Oct; 16(10):683-709. PubMed ID: 12650588
    [TBL] [Abstract][Full Text] [Related]  

  • 6. COX-2 selectivity and inflammatory processes.
    van Ryn J; Trummlitz G; Pairet M
    Curr Med Chem; 2000 Nov; 7(11):1145-61. PubMed ID: 11032964
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.
    Kalgutkar AS; Crews BC; Rowlinson SW; Marnett AB; Kozak KR; Remmel RP; Marnett LJ
    Proc Natl Acad Sci U S A; 2000 Jan; 97(2):925-30. PubMed ID: 10639181
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural basis of the dynamic mechanism of ligand binding to cyclooxygenase.
    Llorens O; Perez JJ; Palomer A; Mauleon D
    Bioorg Med Chem Lett; 1999 Oct; 9(19):2779-84. PubMed ID: 10522690
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Automated docking and molecular dynamics simulations of nimesulide in the cyclooxygenase active site of human prostaglandin-endoperoxide synthase-2 (COX-2).
    García-Nieto R; Pérez C; Gago F
    J Comput Aided Mol Des; 2000 Feb; 14(2):147-60. PubMed ID: 10721503
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design of selective inhibitors of cyclooxygenase-2 as nonulcerogenic anti-inflammatory agents.
    Marnett LJ; Kalgutkar AS
    Curr Opin Chem Biol; 1998 Aug; 2(4):482-90. PubMed ID: 9736921
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular model of the interaction between nimesulide and human cyclooxygenase-2.
    García-Nieto R; Pérez C; Checa A; Gago F
    Rheumatology (Oxford); 1999 May; 38 Suppl 1():14-8. PubMed ID: 10369401
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Rationale for the observed COX-2/COX-1 selectivity of celecoxib from Monte Carlo simulations.
    Price ML; Jorgensen WL
    Bioorg Med Chem Lett; 2001 Jun; 11(12):1541-4. PubMed ID: 11412976
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Conversion of prostaglandin G/H synthase-1 into an enzyme sensitive to PGHS-2-selective inhibitors by a double His513 --> Arg and Ile523 --> val mutation.
    Wong E; Bayly C; Waterman HL; Riendeau D; Mancini JA
    J Biol Chem; 1997 Apr; 272(14):9280-6. PubMed ID: 9083063
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents.
    Kurumbail RG; Stevens AM; Gierse JK; McDonald JJ; Stegeman RA; Pak JY; Gildehaus D; Miyashiro JM; Penning TD; Seibert K; Isakson PC; Stallings WC
    Nature; 1996 Dec 19-26; 384(6610):644-8. PubMed ID: 8967954
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor.
    Riendeau D; Percival MD; Boyce S; Brideau C; Charleson S; Cromlish W; Ethier D; Evans J; Falgueyret JP; Ford-Hutchinson AW; Gordon R; Greig G; Gresser M; Guay J; Kargman S; Léger S; Mancini JA; O'Neill G; Ouellet M; Rodger IW; Thérien M; Wang Z; Webb JK; Wong E; Chan CC
    Br J Pharmacol; 1997 May; 121(1):105-17. PubMed ID: 9146894
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Molecular modelling of the differential interaction between several non-steroidal anti-inflammatory drugs and human prostaglandin endoperoxide H synthase-2 (h-PGHS-2).
    Pouplana R; Lozano JJ; Ruiz J
    J Mol Graph Model; 2002 Jan; 20(4):329-43. PubMed ID: 11858641
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays.
    Riendeau D; Charleson S; Cromlish W; Mancini JA; Wong E; Guay J
    Can J Physiol Pharmacol; 1997 Sep; 75(9):1088-95. PubMed ID: 9365818
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of a new class of selective cyclooxygenase-2 (COX-2) inhibitor that covalently modifies the isozyme.
    Kalgutkar AS; Crews BC; Rowlinson SW; Garner C; Marnett LJ
    Adv Exp Med Biol; 1999; 469():139-43. PubMed ID: 10667322
    [No Abstract]   [Full Text] [Related]  

  • 19. Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.
    Praveen Rao PN; Amini M; Li H; Habeeb AG; Knaus EE
    J Med Chem; 2003 Nov; 46(23):4872-82. PubMed ID: 14584938
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Differential binding mode of diverse cyclooxygenase inhibitors.
    Llorens O; Perez JJ; Palomer A; Mauleon D
    J Mol Graph Model; 2002 Mar; 20(5):359-71. PubMed ID: 11885959
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.