These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

163 related articles for article (PubMed ID: 8663912)

  • 21. Inhibition of histone deacetylase activity is a novel function of the antifolate drug methotrexate.
    Yang PM; Lin JH; Huang WY; Lin YC; Yeh SH; Chen CC
    Biochem Biophys Res Commun; 2010 Jan; 391(3):1396-9. PubMed ID: 20026300
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Evolution of drug resistance in CCRF-CEM human leukemia cells selected by intermittent methotrexate exposure.
    McGuire JJ; Haile WH; Russell CA; Galvin JM; Shane B
    Oncol Res; 1995; 7(10-11):535-43. PubMed ID: 8866666
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Effects and interaction of 7-hydroxy methotrexate and methotrexate in leukaemic cells ex vivo measured by the thymidylate synthase inhibition assay.
    Lingg RM; Hempel G; Rots MG; Van Zantwijk CH; Boos J; Kaspers GJ
    Cancer Chemother Pharmacol; 2005 Sep; 56(3):322-7. PubMed ID: 15868145
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Molecular mechanisms of resistance to antifolates, a review.
    Banerjee D; Ercikan-Abali E; Waltham M; Schnieders B; Hochhauser D; Li WW; Fan J; Gorlick R; Goker E; Bertino JR
    Acta Biochim Pol; 1995; 42(4):457-64. PubMed ID: 8852336
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Novel 8-deaza-5,6,7,8-tetrahydroaminopterin derivatives as dihydrofolate inhibitor: design, synthesis and antifolate activity.
    Zhang Z; Wu J; Ran F; Guo Y; Tian R; Zhou S; Wang X; Liu Z; Zhang L; Cui J; Liu J
    Eur J Med Chem; 2009 Feb; 44(2):764-71. PubMed ID: 18555562
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents.
    Gangjee A; Vidwans AP; Vasudevan A; Queener SF; Kisliuk RL; Cody V; Li R; Galitsky N; Luft JR; Pangborn W
    J Med Chem; 1998 Aug; 41(18):3426-34. PubMed ID: 9719595
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Methotrexate analogues. 21. Divergent influence of alkyl chain length on the dihydrofolate reductase affinity and cytotoxicity of methotrexate monoesters.
    Rosowsky A; Forsch RA; Yu CS; Lazarus H; Beardsley GP
    J Med Chem; 1984 May; 27(5):605-9. PubMed ID: 6585550
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Increasing methotrexate resistance by combination of active-site mutations in human dihydrofolate reductase.
    Volpato JP; Fossati E; Pelletier JN
    J Mol Biol; 2007 Oct; 373(3):599-611. PubMed ID: 17868689
    [TBL] [Abstract][Full Text] [Related]  

  • 29. [The solid-phase synthesis of methotrexate-alpha-peptides].
    Shi PT; Hao XK; Chen Y; Zhang YH; Tao QY
    Yao Xue Xue Bao; 1997; 32(2):106-9. PubMed ID: 11243192
    [TBL] [Abstract][Full Text] [Related]  

  • 30. 2-tier bacterial and in vitro selection of active and methotrexate-resistant variants of human dihydrofolate reductase.
    Fossati E; Volpato JP; Poulin L; Guerrero V; Dugas DA; Pelletier JN
    J Biomol Screen; 2008 Jul; 13(6):504-14. PubMed ID: 18566481
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Delivery of radionuclides to pretargeted monoclonal antibodies using dihydrofolate reductase and methotrexate in an affinity system.
    Hawkins GA; McCabe RP; Kim CH; Subramanian R; Bredehorst R; McCullers GA; Vogel CW; Hanna MG; Pomato N
    Cancer Res; 1993 May; 53(10 Suppl):2368-73. PubMed ID: 8485723
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Design and synthesis of dihydrofolate reductase inhibitors encompassing a bridging ester group. Evaluation in a mouse colitis model.
    Graffner-Nordberg M; Fyfe M; Brattsand R; Mellgård B; Hallberg A
    J Med Chem; 2003 Jul; 46(16):3455-62. PubMed ID: 12877583
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Methotrexate analogues. 13. Chemical and pharmacological studies on amide, hydrazide, and hydroxamic acid derivatives of the glutamate side chain.
    Rosowsky A; Yu CS; Uren J; Lazarus H; Wick M
    J Med Chem; 1981 May; 24(5):559-67. PubMed ID: 6787199
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function.
    Schormann N; Senkovich O; Walker K; Wright DL; Anderson AC; Rosowsky A; Ananthan S; Shinkre B; Velu S; Chattopadhyay D
    Proteins; 2008 Dec; 73(4):889-901. PubMed ID: 18536013
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Novel 5-substituted, 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors with antiangiogenic and antitumor activity.
    Gangjee A; Zeng Y; Ihnat M; Warnke LA; Green DW; Kisliuk RL; Lin FT
    Bioorg Med Chem; 2005 Sep; 13(18):5475-91. PubMed ID: 16039863
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Methotrexate-alpha-phenylalanine: optimization of methotrexate prodrug for activation by carboxypeptidase A-monoclonal antibody conjugate.
    Vitols KS; Haag-Zeino B; Baer T; Montejano YD; Huennekens FM
    Cancer Res; 1995 Feb; 55(3):478-81. PubMed ID: 7834611
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Liposomes containing alkylated methotrexate analogues for phospholipase A(2) mediated tumor targeted drug delivery.
    Kaasgaard T; Andresen TL; Jensen SS; Holte RO; Jensen LT; Jørgensen K
    Chem Phys Lipids; 2009 Feb; 157(2):94-103. PubMed ID: 19094974
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Synthesis and potent antifolate activity and cytotoxicity of B-ring deaza analogues of the nonpolyglutamatable dihydrofolate reductase inhibitor Nalpha-(4-amino-4-deoxypteroyl)-Ndelta-hemiphthaloyl- L-ornithine (PT523).
    Rosowsky A; Wright JE; Vaidya CM; Bader H; Forsch RA; Mota CE; Pardo J; Chen CS; Chen YN
    J Med Chem; 1998 Dec; 41(26):5310-9. PubMed ID: 9857098
    [TBL] [Abstract][Full Text] [Related]  

  • 39. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.
    Shih C; Chen VJ; Gossett LS; Gates SB; MacKellar WC; Habeck LL; Shackelford KA; Mendelsohn LG; Soose DJ; Patel VF; Andis SL; Bewley JR; Rayl EA; Moroson BA; Beardsley GP; Kohler W; Ratnam M; Schultz RM
    Cancer Res; 1997 Mar; 57(6):1116-23. PubMed ID: 9067281
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.
    Robson C; Meek MA; Grunwaldt JD; Lambert PA; Queener SF; Schmidt D; Griffin RJ
    J Med Chem; 1997 Sep; 40(19):3040-8. PubMed ID: 9301666
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 9.