BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

386 related articles for article (PubMed ID: 8667365)

  • 1. Structure-activity studies of 6-(tetrazolylalkyl)-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 1. Effects of stereochemistry, chain length, and chain substitution.
    Ornstein PL; Arnold MB; Allen NK; Bleisch T; Borromeo PS; Lugar CW; Leander JD; Lodge D; Schoepp DD
    J Med Chem; 1996 May; 39(11):2219-31. PubMed ID: 8667365
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-activity studies of 6-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 2. Effects of distal acid bioisosteric substitution, absolute stereochemical preferences, and in vivo activity.
    Ornstein PL; Arnold MB; Allen NK; Bleisch T; Borromeo PS; Lugar CW; Leander JD; Lodge D; Schoepp DD
    J Med Chem; 1996 May; 39(11):2232-44. PubMed ID: 8667366
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Heteroaryl analogues of AMPA. Synthesis and quantitative structure-activity relationships.
    Bang-Andersen B; Lenz SM; Skjaerbaek N; Søby KK; Hansen HO; Ebert B; Bøgesø KP; Krogsgaard-Larsen P
    J Med Chem; 1997 Aug; 40(18):2831-42. PubMed ID: 9288165
    [TBL] [Abstract][Full Text] [Related]  

  • 4. SPD 502: a water-soluble and in vivo long-lasting AMPA antagonist with neuroprotective activity.
    Nielsen EO; Varming T; Mathiesen C; Jensen LH; Moller A; Gouliaev AH; Wätjen F; Drejer J
    J Pharmacol Exp Ther; 1999 Jun; 289(3):1492-501. PubMed ID: 10336544
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo.
    Weiss B; Alt A; Ogden AM; Gates M; Dieckman DK; Clemens-Smith A; Ho KH; Jarvie K; Rizkalla G; Wright RA; Calligaro DO; Schoepp D; Mattiuz EL; Stratford RE; Johnson B; Salhoff C; Katofiasc M; Phebus LA; Schenck K; Cohen M; Filla SA; Ornstein PL; Johnson KW; Bleakman D
    J Pharmacol Exp Ther; 2006 Aug; 318(2):772-81. PubMed ID: 16690725
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-activity relationships in a series of 2(1H)-quinolones bearing different acidic function in the 3-position: 6,7-dichloro-2(1H)-oxoquinoline-3-phosphonic acid, a new potent and selective AMPA/kainate antagonist with neuroprotective properties.
    Desos P; Lepagnol JM; Morain P; Lestage P; Cordi AA
    J Med Chem; 1996 Jan; 39(1):197-206. PubMed ID: 8568808
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Effects of decahydroisoquinoline-3-carboxylic acid monohydrate, a novel AMPA receptor antagonist, on glutamate-induced CA2+ responses and neurotoxicity in rat cortical and cerebellar granule neurons.
    Liljequist S; Cebers G; Kalda A
    Biochem Pharmacol; 1995 Nov; 50(11):1761-74. PubMed ID: 8615854
    [TBL] [Abstract][Full Text] [Related]  

  • 8. In vitro and in vivo antagonism of AMPA receptor activation by (3S, 4aR, 6R, 8aR)-6-[2-(1(2)H-tetrazole-5-yl) ethyl] decahydroisoquinoline-3-carboxylic acid.
    Schoepp DD; Lodge D; Bleakman D; Leander JD; Tizzano JP; Wright RA; Palmer AJ; Salhoff CR; Ornstein PL
    Neuropharmacology; 1995 Sep; 34(9):1159-68. PubMed ID: 8532186
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Excitatory amino acid receptor antagonists: resolution, absolute stereochemistry, and pharmacology of (S)- and (R)-2-amino-2-(5-tert-butyl-3-hydroxyisoxazol-4-yl)acetic acid (ATAA).
    Johansen TN; Frydenvang K; Ebert B; Madsen U; Krogsgaard-Larsen P
    Chirality; 1997; 9(5-6):529-36. PubMed ID: 9329180
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Novel AMPA receptor antagonists: synthesis and structure-activity relationships of 1-hydroxy-7-(1H-imidazol-1-yl)-6-nitro-2,3(1H,4H)- quinoxalinedione and related compounds.
    Ohmori J; Shimizu-Sasamata M; Okada M; Sakamoto S
    J Med Chem; 1996 Sep; 39(20):3971-9. PubMed ID: 8831762
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors.
    Cai SX; Huang JC; Espitia SA; Tran M; Ilyin VI; Hawkinson JE; Woodward RM; Weber E; Keana JF
    J Med Chem; 1997 Oct; 40(22):3679-86. PubMed ID: 9357535
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The pharmacology of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate antagonists and their role in cerebral ischaemia.
    Gill R
    Cerebrovasc Brain Metab Rev; 1994; 6(3):225-56. PubMed ID: 7529037
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 8-(1H-imidazol-1-yl)-7-nitro-4(5H)-imidazo[1,2-alpha]quinoxalinone and related compounds: synthesis and structure-activity relationships for the AMPA-type non-NMDA receptor.
    Ohmori J; Shimizu-Sasamata M; Okada M; Sakamoto S
    J Med Chem; 1997 Jun; 40(13):2053-63. PubMed ID: 9207947
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahyd roisoquinoline- 3-carboxylic acid (LY293558) and its racemate (LY215490).
    Schoepp DD; Salhoff CR; Fuson KS; Sacaan AI; Tizzano JP; Ornstein PL; May PC
    J Neural Transm (Vienna); 1996; 103(8-9):905-16. PubMed ID: 9013384
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships.
    Falch E; Brehm L; Mikkelsen I; Johansen TN; Skjaerbaek N; Nielsen B; Stensbøl TB; Ebert B; Krogsgaard-Larsen P
    J Med Chem; 1998 Jul; 41(14):2513-23. PubMed ID: 9651156
    [TBL] [Abstract][Full Text] [Related]  

  • 16. (3SR,4aRS,6SR,8aRS)-6-(1H-tetrazol-5-yl)decahydroisoquinoline-3-carboxylic acid, a novel, competitive, systemically active NMDA and AMPA receptor antagonist.
    Ornstein PL; Arnold MB; Allen NK; Leander JD; Tizzano JP; Lodge D; Schoepp DD
    J Med Chem; 1995 Dec; 38(25):4885-90. PubMed ID: 8523401
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action.
    Ornstein PL; Schoepp DD; Arnold MB; Leander JD; Lodge D; Paschal JW; Elzey T
    J Med Chem; 1991 Jan; 34(1):90-7. PubMed ID: 1825117
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure-activity relationships of alkyl- and alkoxy-substituted 1,4-dihydroquinoxaline-2,3-diones: potent and systemically active antagonists for the glycine site of the NMDA receptor.
    Cai SX; Kher SM; Zhou ZL; Ilyin V; Espitia SA; Tran M; Hawkinson JE; Woodward RM; Weber E; Keana JF
    J Med Chem; 1997 Feb; 40(5):730-8. PubMed ID: 9057859
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 6-substituted decahydroisoquinoline-3-carboxylic acids as potent and selective conformationally constrained NMDA receptor antagonists.
    Ornstein PL; Schoepp DD; Arnold MB; Augenstein NK; Lodge D; Millar JD; Chambers J; Campbell J; Paschal JW; Zimmerman DM
    J Med Chem; 1992 Sep; 35(19):3547-60. PubMed ID: 1404235
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4- oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists.
    Catarzi D; Colotta V; Varano F; Calabri FR; Filacchioni G; Galli A; Costagli C; Carlà V
    J Med Chem; 2004 Jan; 47(1):262-72. PubMed ID: 14695840
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.