BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

626 related articles for article (PubMed ID: 8674051)

  • 1. Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.
    Shimada T; Hayes CL; Yamazaki H; Amin S; Hecht SS; Guengerich FP; Sutter TR
    Cancer Res; 1996 Jul; 56(13):2979-84. PubMed ID: 8674051
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons.
    Shimada T; Martin MV; Pruess-Schwartz D; Marnett LJ; Guengerich FP
    Cancer Res; 1989 Nov; 49(22):6304-12. PubMed ID: 2509067
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.
    Shimada T; Iwasaki M; Martin MV; Guengerich FP
    Cancer Res; 1989 Jun; 49(12):3218-28. PubMed ID: 2655891
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009.
    Shimada T; Oda Y; Gillam EM; Guengerich FP; Inoue K
    Drug Metab Dispos; 2001 Sep; 29(9):1176-82. PubMed ID: 11502724
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase.
    Shimada T; Gillam EM; Oda Y; Tsumura F; Sutter TR; Guengerich FP; Inoue K
    Chem Res Toxicol; 1999 Jul; 12(7):623-9. PubMed ID: 10409402
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Metabolic activation of heterocyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human NADPH-P450 reductase and bacterial O-acetyltransferase.
    Oda Y; Aryal P; Terashita T; Gillam EM; Guengerich FP; Shimada T
    Mutat Res; 2001 May; 492(1-2):81-90. PubMed ID: 11377247
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal liver and adult lungs.
    Shimada T; Yamazaki H; Mimura M; Wakamiya N; Ueng YF; Guengerich FP; Inui Y
    Drug Metab Dispos; 1996 May; 24(5):515-22. PubMed ID: 8723730
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Comparisons of (+/-)-benzo[a]pyrene-trans-7,8-dihydrodiol activation by human cytochrome P450 and aldo-keto reductase enzymes: effect of redox state and expression levels.
    Quinn AM; Penning TM
    Chem Res Toxicol; 2008 May; 21(5):1086-94. PubMed ID: 18402469
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibition of human cytochrome P450 1A1-, 1A2-, and 1B1-mediated activation of procarcinogens to genotoxic metabolites by polycyclic aromatic hydrocarbons.
    Shimada T; Guengerich FP
    Chem Res Toxicol; 2006 Feb; 19(2):288-94. PubMed ID: 16485905
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Metabolic activation of carcinogenic 1-nitropyrene by human cytochrome P450 1B1 in Salmonella typhimurium strain expressing an O-acetyltransferase in SOS/umu assay.
    Hatanaka N; Yamazaki H; Oda Y; Guengerich FP; Nakajima M; Yokoi T
    Mutat Res; 2001 Oct; 497(1-2):223-33. PubMed ID: 11525925
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inhibition of human cytochrome P450-catalyzed oxidations of xenobiotics and procarcinogens by synthetic organoselenium compounds.
    Shimada T; El-Bayoumy K; Upadhyaya P; Sutter TR; Guengerich FP; Yamazaki H
    Cancer Res; 1997 Nov; 57(21):4757-64. PubMed ID: 9354437
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Specificity of cDNA-expressed human and rodent cytochrome P450s in the oxidative metabolism of the potent carcinogen 7,12-dimethylbenz[a]anthracene.
    Shou M; Korzekwa KR; Krausz KW; Buters JT; Grogan J; Goldfarb I; Hardwick JP; Gonzalez FJ; Gelboin HV
    Mol Carcinog; 1996 Dec; 17(4):241-9. PubMed ID: 8989918
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Construction of a human cytochrome P450 1A1: rat NADPH-cytochrome P450 reductase fusion protein cDNA and expression in Escherichia coli, purification, and catalytic properties of the enzyme in bacterial cells and after purification.
    Chun YJ; Shimada T; Guengerich FP
    Arch Biochem Biophys; 1996 Jun; 330(1):48-58. PubMed ID: 8651703
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Metabolism of promutagens catalyzed by Drosophila melanogaster CYP6A2 enzyme in Saccharomyces cerevisiae.
    Saner C; Weibel B; Wurgler FE; Sengstag C
    Environ Mol Mutagen; 1996; 27(1):46-58. PubMed ID: 8625948
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1.
    Yamazaki H; Hatanaka N; Kizu R; Hayakawa K; Shimada N; Guengerich FP; Nakajima M; Yokoi T
    Mutat Res; 2000 Dec; 472(1-2):129-38. PubMed ID: 11113705
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens.
    Shimada T; Yun CH; Yamazaki H; Gautier JC; Beaune PH; Guengerich FP
    Mol Pharmacol; 1992 May; 41(5):856-64. PubMed ID: 1588920
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Procarcinogen activation by cytochrome P450 3A4 and 3A5 expressed in Escherichia coli and by human liver microsomes.
    Yamazaki H; Inui Y; Wrighton SA; Guengerich FP; Shimada T
    Carcinogenesis; 1995 Sep; 16(9):2167-70. PubMed ID: 7554070
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Activation and inactivation of carcinogenic dihaloalkanes and other compounds by glutathione S-transferase 5-5 in Salmonella typhimurium tester strain NM5004.
    Shimada T; Yamazaki H; Oda Y; Hiratsuka A; Watabe T; Guengerich FP
    Chem Res Toxicol; 1996; 9(1):333-40. PubMed ID: 8924613
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Metabolism of 5-methylchrysene and 6-methylchrysene by human hepatic and pulmonary cytochrome P450 enzymes.
    Koehl W; Amin S; Staretz ME; Ueng YF; Yamazaki H; Tateishi T; Guengerich FP; Hecht SS
    Cancer Res; 1996 Jan; 56(2):316-24. PubMed ID: 8542586
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice.
    Shimada T; Inoue K; Suzuki Y; Kawai T; Azuma E; Nakajima T; Shindo M; Kurose K; Sugie A; Yamagishi Y; Fujii-Kuriyama Y; Hashimoto M
    Carcinogenesis; 2002 Jul; 23(7):1199-207. PubMed ID: 12117779
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 32.