169 related articles for article (PubMed ID: 8679643)
1. Thermodynamic stabilization of nucleotide binding to thymidylate synthase by a potent benzoquinazoline folate analogue inhibitor.
Chen CH; Davis RA; Maley F
Biochemistry; 1996 Jul; 35(26):8786-93. PubMed ID: 8679643
[TBL] [Abstract][Full Text] [Related]
2. Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89.
Weichsel A; Montfort WR; Cieśla J; Maley F
Proc Natl Acad Sci U S A; 1995 Apr; 92(8):3493-7. PubMed ID: 7724588
[TBL] [Abstract][Full Text] [Related]
3. Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady-state catalysis.
Spencer HT; Villafranca JE; Appleman JR
Biochemistry; 1997 Apr; 36(14):4212-22. PubMed ID: 9100016
[TBL] [Abstract][Full Text] [Related]
4. Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254.
Fantz C; Shaw D; Jennings W; Forsthoefel A; Kitchens M; Phan J; Minor W; Lebioda L; Berger FG; Spencer HT
Mol Pharmacol; 2000 Feb; 57(2):359-66. PubMed ID: 10648646
[TBL] [Abstract][Full Text] [Related]
5. Biphasic binding of 5-fluoro-2'-deoxyuridylate to human thymidylate synthase.
Reilly RT; Barbour KW; Dunlap RB; Berger FG
Mol Pharmacol; 1995 Jul; 48(1):72-9. PubMed ID: 7623777
[TBL] [Abstract][Full Text] [Related]
6. Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate.
Hyatt DC; Maley F; Montfort WR
Biochemistry; 1997 Apr; 36(15):4585-94. PubMed ID: 9109668
[TBL] [Abstract][Full Text] [Related]
7. In vitro uptake, anabolism, and cellular retention of 1843U89 and other benzoquinazoline inhibitors of thymidylate synthase.
Hanlon MH; Ferone R
Cancer Res; 1996 Jul; 56(14):3301-6. PubMed ID: 8764125
[TBL] [Abstract][Full Text] [Related]
8. The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition.
Stout TJ; Stroud RM
Structure; 1996 Jan; 4(1):67-77. PubMed ID: 8805515
[TBL] [Abstract][Full Text] [Related]
9. Low folate conditions may enhance the interaction of trifluorothymidine with antifolates in colon cancer cells.
Temmink OH; Hoogeland MF; Fukushima M; Peters GJ
Cancer Chemother Pharmacol; 2006 Jan; 57(2):171-9. PubMed ID: 16010590
[TBL] [Abstract][Full Text] [Related]
10. Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions.
Peters GJ; Smitskamp-Wilms E; Smid K; Pinedo HM; Jansen G
Cancer Res; 1999 Nov; 59(21):5529-35. PubMed ID: 10554030
[TBL] [Abstract][Full Text] [Related]
11. Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.
Jones TR; Varney MD; Webber SE; Lewis KK; Marzoni GP; Palmer CL; Kathardekar V; Welsh KM; Webber S; Matthews DA; Appelt K; Smith WW; Janson CA; Villafranca JE; Bacquet RJ; Howland EF; Booth CL; Herrmann SM; Ward RW; White J; Moomaw EW; Bartlett CA; Morse CA
J Med Chem; 1996 Feb; 39(4):904-17. PubMed ID: 8632414
[TBL] [Abstract][Full Text] [Related]
12. The effect of 5-substitution in the pyrimidine ring of dUMP on the interaction with thymidylate synthase: molecular modeling and QSAR.
Jarmuła A; Cieplak P; Krygowski TM; Rode W
Bioorg Med Chem; 2007 Mar; 15(6):2346-58. PubMed ID: 17275316
[TBL] [Abstract][Full Text] [Related]
13. Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase.
Finer-Moore JS; Liu L; Schafmeister CE; Birdsall DL; Mau T; Santi DV; Stroud RM
Biochemistry; 1996 Apr; 35(16):5125-36. PubMed ID: 8611496
[TBL] [Abstract][Full Text] [Related]
14. Crystal structures of thymidylate synthase mutant R166Q: structural basis for the nearly complete loss of catalytic activity.
Sotelo-Mundo RR; Changchien L; Maley F; Montfort WR
J Biochem Mol Toxicol; 2006; 20(2):88-92. PubMed ID: 16615077
[TBL] [Abstract][Full Text] [Related]
15. Effect of halogen substitutions on dUMP to stability of thymidylate synthase/dUMP/mTHF ternary complex using molecular dynamics simulation.
Kaiyawet N; Rungrotmongkol T; Hannongbua S
J Chem Inf Model; 2013 Jun; 53(6):1315-23. PubMed ID: 23705822
[TBL] [Abstract][Full Text] [Related]
16. Folate-based thymidylate synthase inhibitors as anticancer drugs.
Jackman AL; Calvert AH
Ann Oncol; 1995 Nov; 6(9):871-81. PubMed ID: 8624289
[TBL] [Abstract][Full Text] [Related]
17. A hydroxyl group at residue 216 is essential for catalysis by human thymidylate synthase.
Williams AW; Dunlap RB; Berger SH
Biochemistry; 1998 May; 37(20):7096-102. PubMed ID: 9585520
[TBL] [Abstract][Full Text] [Related]
18. A molecular modeling study of the interaction of 2'-fluoro-substituted analogues of dUMP/FdUMP with thymidylate synthase.
Jarmuła A; Dowierciał A; Rode W
Bioorg Med Chem Lett; 2008 Apr; 18(8):2701-8. PubMed ID: 18362071
[TBL] [Abstract][Full Text] [Related]
19. Deoxyuridylate effects on thymidylate synthase-5-fluorodeoxyuridylate-folate ternary complex formation.
Spears CP; Hayes AA; Shahinian AH; Danenberg PV; Frösing R; Gustavsson BG
Biochem Pharmacol; 1989 Sep; 38(18):2985-93. PubMed ID: 2783153
[TBL] [Abstract][Full Text] [Related]
20. Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.
van Triest B; Pinedo HM; van Hensbergen Y; Smid K; Telleman F; Schoenmakers PS; van der Wilt CL; van Laar JA; Noordhuis P; Jansen G; Peters GJ
Clin Cancer Res; 1999 Mar; 5(3):643-54. PubMed ID: 10100718
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
