BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

201 related articles for article (PubMed ID: 8687412)

  • 1. Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol.
    Ellis SW; Rowland K; Ackland MJ; Rekka E; Simula AP; Lennard MS; Wolf CR; Tucker GT
    Biochem J; 1996 Jun; 316 ( Pt 2)(Pt 2):647-54. PubMed ID: 8687412
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6.
    Ellis SW; Hayhurst GP; Lightfoot T; Smith G; Harlow J; Rowland-Yeo K; Larsson C; Mahling J; Lim CK; Wolf CR; Blackburn MG; Lennard MS; Tucker GT
    Biochem J; 2000 Feb; 345 Pt 3(Pt 3):565-71. PubMed ID: 10642515
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Regioselective and stereoselective oxidation of metoprolol and bufuralol catalyzed by microsomes containing cDNA-expressed human P4502D6.
    Mautz DS; Nelson WL; Shen DD
    Drug Metab Dispos; 1995 Apr; 23(4):513-7. PubMed ID: 7600921
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Comparison of substrate metabolism by wild type CYP2D6 protein and a variant containing methionine, not valine, at position 374.
    Crespi CL; Steimel DT; Penman BW; Korzekwa KR; Fernandez-Salguero P; Buters JT; Gelboin HV; Gonzalez FJ; Idle JR; Daly AK
    Pharmacogenetics; 1995 Aug; 5(4):234-43. PubMed ID: 8528270
    [TBL] [Abstract][Full Text] [Related]  

  • 5. An evaluation of cytochrome P450 isoform activities in the female dark agouti (DA) rat: relevance to its use as a model of the CYP2D6 poor metaboliser phenotype.
    Barham HM; Lennard MS; Tucker GT
    Biochem Pharmacol; 1994 Apr; 47(8):1295-307. PubMed ID: 8185638
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Catalytic activities of human debrisoquine 4-hydroxylase cytochrome P450 (CYP2D6) expressed in yeast.
    Ellis SW; Ching MS; Watson PF; Henderson CJ; Simula AP; Lennard MS; Tucker GT; Woods HF
    Biochem Pharmacol; 1992 Aug; 44(4):617-20. PubMed ID: 1510710
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Regio- and Stereo-Selective Oxidation of a Cardiovascular Drug, Metoprolol, Mediated by Cytochrome P450 2D and 3A Enzymes in Marmoset Livers.
    Uehara S; Ishii S; Uno Y; Inoue T; Sasaki E; Yamazaki H
    Drug Metab Dispos; 2017 Aug; 45(8):896-899. PubMed ID: 28495902
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of the enantioselective oxidative metabolism of metoprolol by verapamil in human liver microsomes.
    Kim M; Shen DD; Eddy AC; Nelson WL; Roskos LK
    Drug Metab Dispos; 1993; 21(2):309-17. PubMed ID: 8097702
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102: structural studies on specific CYP2D6 substrate metabolism.
    Lewis DF; Eddershaw PJ; Goldfarb PS; Tarbit MH
    Xenobiotica; 1997 Apr; 27(4):319-39. PubMed ID: 9149373
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Comparison of CYP2D6 content and metoprolol oxidation between microsomes isolated from human livers and small intestines.
    Madani S; Paine MF; Lewis L; Thummel KE; Shen DD
    Pharm Res; 1999 Aug; 16(8):1199-205. PubMed ID: 10468020
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol and dextromethorphan.
    Uehara S; Uno Y; Hagihira Y; Murayama N; Shimizu M; Inoue T; Sasaki E; Yamazaki H
    Xenobiotica; 2015; 45(9):766-72. PubMed ID: 25801057
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The oxidative metabolism of metoprolol in human liver microsomes: inhibition by the selective serotonin reuptake inhibitors.
    Belpaire FM; Wijnant P; Temmerman A; Rasmussen BB; Brøsen K
    Eur J Clin Pharmacol; 1998 May; 54(3):261-4. PubMed ID: 9681670
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6.
    Hayhurst GP; Harlow J; Chowdry J; Gross E; Hilton E; Lennard MS; Tucker GT; Ellis SW
    Biochem J; 2001 Apr; 355(Pt 2):373-9. PubMed ID: 11284724
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Identification of the human cytochromes p450 responsible for in vitro formation of R- and S-norfluoxetine.
    Ring BJ; Eckstein JA; Gillespie JS; Binkley SN; VandenBranden M; Wrighton SA
    J Pharmacol Exp Ther; 2001 Jun; 297(3):1044-50. PubMed ID: 11356927
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Regioselectivity and enantioselectivity of metoprolol oxidation by two variants of cDNA-expressed P4502D6.
    Mautz DS; Shen DD; Nelson WL
    Pharm Res; 1995 Dec; 12(12):2053-6. PubMed ID: 8786988
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes.
    Otton SV; Crewe HK; Lennard MS; Tucker GT; Woods HF
    J Pharmacol Exp Ther; 1988 Oct; 247(1):242-7. PubMed ID: 3171974
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding.
    Modi S; Paine MJ; Sutcliffe MJ; Lian LY; Primrose WU; Wolf CR; Roberts GC
    Biochemistry; 1996 Apr; 35(14):4540-50. PubMed ID: 8605204
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Enantioselectivity of bunitrolol 4-hydroxylation is reversed by the change of an amino acid residue from valine to methionine at position 374 of cytochrome P450-2D6.
    Narimatsu S; Kato R; Horie T; Ono S; Tsutsui M; Yabusaki Y; Ohmori S; Kitada M; Ichioka T; Shimada N; Kato R; Ishikawa T
    Chirality; 1999; 11(1):1-9. PubMed ID: 9914647
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.
    Ellis SW; Hayhurst GP; Smith G; Lightfoot T; Wong MM; Simula AP; Ackland MJ; Sternberg MJ; Lennard MS; Tucker GT
    J Biol Chem; 1995 Dec; 270(49):29055-8. PubMed ID: 7493924
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Effect of steroids on the cytochrome P4502D6-catalysed metabolism of metoprolol.
    Pepper JM; Lennard MS; Tucker GT; Woods HF
    Pharmacogenetics; 1991 Nov; 1(2):119-22. PubMed ID: 1844870
    [No Abstract]   [Full Text] [Related]  

    [Next]    [New Search]
    of 11.