BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

119 related articles for article (PubMed ID: 8691451)

  • 1. Synthesis and biological evaluation of N alpha-(4-amino-4-deoxy-10-methylpteroyl)-DL-4,4-difluoroornithine.
    Tsukamoto T; Haile WH; McGuire JJ; Coward JK
    J Med Chem; 1996 Jun; 39(13):2536-40. PubMed ID: 8691451
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and biological evaluation of DL-4,4-difluoroglutamic acid and DL-gamma,gamma-difluoromethotrexate.
    Tsukamoto T; Kitazume T; McGuire JJ; Coward JK
    J Med Chem; 1996 Jan; 39(1):66-72. PubMed ID: 8568828
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Analogues of N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523) modified in the side chain: synthesis and biological evaluation.
    Rosowsky A; Vaidya CM; Bader H; Wright JE; Teicher BA
    J Med Chem; 1997 Jan; 40(3):286-99. PubMed ID: 9022795
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and potent antifolate activity and cytotoxicity of B-ring deaza analogues of the nonpolyglutamatable dihydrofolate reductase inhibitor Nalpha-(4-amino-4-deoxypteroyl)-Ndelta-hemiphthaloyl- L-ornithine (PT523).
    Rosowsky A; Wright JE; Vaidya CM; Bader H; Forsch RA; Mota CE; Pardo J; Chen CS; Chen YN
    J Med Chem; 1998 Dec; 41(26):5310-9. PubMed ID: 9857098
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells.
    Chen G; Wright JE; Rosowsky A
    Mol Pharmacol; 1995 Oct; 48(4):758-65. PubMed ID: 7476904
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity.
    Rosowsky A; Bader H; Cucchi CA; Moran RG; Kohler W; Freisheim JH
    J Med Chem; 1988 Jul; 31(7):1332-7. PubMed ID: 3385730
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and in vitro biological activity of new deaza analogues of folic acid, aminopterin, and methotrexate with an L-ornithine side chain.
    Rosowsky A; Forsch RA; Bader H; Freisheim JH
    J Med Chem; 1991 Apr; 34(4):1447-54. PubMed ID: 2016722
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and biological activity of folic acid and methotrexate analogues containing L-threo-(2S,4S)-4-fluoroglutamic acid and DL-3,3-difluoroglutamic acid.
    Hart BP; Haile WH; Licato NJ; Bolanowska WE; McGuire JJ; Coward JK
    J Med Chem; 1996 Jan; 39(1):56-65. PubMed ID: 8568827
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents.
    Gangjee A; Lin X; Kisliuk RL; McGuire JJ
    J Med Chem; 2005 Nov; 48(23):7215-22. PubMed ID: 16279780
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and biologic activity of new side-chain-altered methotrexate and aminopterin analogs with dual inhibitory action against dihydrofolate reductase and folylpolyglutamate synthetase.
    Rosowsky A; Moran RG; Freisheim JH; Bader H; Forsch RA; Solan VC
    NCI Monogr; 1987; (5):145-52. PubMed ID: 3431589
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 5-deazafolate analogues with a rotationally restricted glutamate or ornithine side chain: synthesis and binding interaction with folylpolyglutamate synthetase.
    Rosowsky A; Forsch RA; Null A; Moran RG
    J Med Chem; 1999 Sep; 42(18):3510-9. PubMed ID: 10479284
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents.
    Gangjee A; Vidwans AP; Vasudevan A; Queener SF; Kisliuk RL; Cody V; Li R; Galitsky N; Luft JR; Pangborn W
    J Med Chem; 1998 Aug; 41(18):3426-34. PubMed ID: 9719595
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mechanism-based inhibition of human folylpolyglutamate synthetase: design, synthesis, and biochemical characterization of a phosphapeptide mimic of the tetrahedral intermediate.
    Tsukamoto T; Haile WH; McGuire JJ; Coward JK
    Arch Biochem Biophys; 1998 Jul; 355(1):109-18. PubMed ID: 9647673
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain.
    Rosowsky A; Freisheim JH; Moran RG; Solan VC; Bader H; Wright JE; Radike-Smith M
    J Med Chem; 1986 May; 29(5):655-60. PubMed ID: 2871191
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases.
    Gangjee A; Vasudevan A; Queener SF; Kisliuk RL
    J Med Chem; 1996 Mar; 39(7):1438-46. PubMed ID: 8691474
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and in vitro antitumor activity of new deaza analogues of the nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (PT523).
    Vaidya CM; Wright JE; Rosowsky A
    J Med Chem; 2002 Apr; 45(8):1690-6. PubMed ID: 11931624
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Novel 8-deaza-5,6,7,8-tetrahydroaminopterin derivatives as dihydrofolate inhibitor: design, synthesis and antifolate activity.
    Zhang Z; Wu J; Ran F; Guo Y; Tian R; Zhou S; Wang X; Liu Z; Zhang L; Cui J; Liu J
    Eur J Med Chem; 2009 Feb; 44(2):764-71. PubMed ID: 18555562
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Lipophilic conjugates of methotrexate with short-chain alkylamino acids as DHFR inhibitors. Synthesis, biological evaluation, and molecular modeling.
    Pignatello R; Guccione S; Forte S; Di Giacomo C; Sorrenti V; Vicari L; Uccello Barretta G; Balzano F; Puglisi G
    Bioorg Med Chem; 2004 Jun; 12(11):2951-64. PubMed ID: 15142554
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Potent inhibition of human folylpolyglutamate synthetase by a phosphinic acid mimic of the tetrahedral reaction intermediate.
    McGuire JJ; Haile WH; Valiaeva N; Bartley D; Guo J; Coward JK
    Biochem Pharmacol; 2003 Feb; 65(3):315-8. PubMed ID: 12527324
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design, synthesis, and biological activities of classical N-[4-[2-(2-amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and its 6-methyl derivative as potential dual inhibitors of thymidylate synthase and dihydrofolate reductase and as potential antitumor agents.
    Gangjee A; Yu J; Kisliuk RL; Haile WH; Sobrero G; McGuire JJ
    J Med Chem; 2003 Feb; 46(4):591-600. PubMed ID: 12570380
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.