These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

178 related articles for article (PubMed ID: 8740360)

  • 1. X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily.
    Dhanaraj V; Ye QZ; Johnson LL; Hupe DJ; Ortwine DF; Dunbar JB; Rubin JR; Pavlovsky A; Humblet C; Blundell TL
    Structure; 1996 Apr; 4(4):375-86. PubMed ID: 8740360
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Designing inhibitors of the metalloproteinase superfamily: comparative analysis of representative structures.
    Dhanaraj V; Ye QZ; Johnson LL; Hupe DJ; Ortwine DF; Dunbar JB; Rubin JR; Pavlovsky A; Humblet C; Blundell TL
    Drug Des Discov; 1996 Apr; 13(3-4):3-14. PubMed ID: 8874040
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Crystal structure of the stromelysin catalytic domain at 2.0 A resolution: inhibitor-induced conformational changes.
    Chen L; Rydel TJ; Gu F; Dunaway CM; Pikul S; Dunham KM; Barnett BL
    J Mol Biol; 1999 Oct; 293(3):545-57. PubMed ID: 10543949
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Solution structure of the catalytic domain of human collagenase-3 (MMP-13) complexed to a potent non-peptidic sulfonamide inhibitor: binding comparison with stromelysin-1 and collagenase-1.
    Zhang X; Gonnella NC; Koehn J; Pathak N; Ganu V; Melton R; Parker D; Hu SI; Nam KY
    J Mol Biol; 2000 Aug; 301(2):513-24. PubMed ID: 10926524
    [TBL] [Abstract][Full Text] [Related]  

  • 5. X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design.
    Grams F; Reinemer P; Powers JC; Kleine T; Pieper M; Tschesche H; Huber R; Bode W
    Eur J Biochem; 1995 Mar; 228(3):830-41. PubMed ID: 7737183
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Crystal structures of the catalytic domain of human stromelysin-1 (MMP-3) and collagenase-3 (MMP-13) with a hydroxamic acid inhibitor SM-25453.
    Kohno T; Hochigai H; Yamashita E; Tsukihara T; Kanaoka M
    Biochem Biophys Res Commun; 2006 May; 344(1):315-22. PubMed ID: 16603129
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Solution structure of the catalytic domain of human stromelysin-1 complexed to a potent, nonpeptidic inhibitor.
    Li YC; Zhang X; Melton R; Ganu V; Gonnella NC
    Biochemistry; 1998 Oct; 37(40):14048-56. PubMed ID: 9760240
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Solution structure of the catalytic domain of human stromelysin complexed with a hydrophobic inhibitor.
    Van Doren SR; Kurochkin AV; Hu W; Ye QZ; Johnson LL; Hupe DJ; Zuiderweg ER
    Protein Sci; 1995 Dec; 4(12):2487-98. PubMed ID: 8580839
    [TBL] [Abstract][Full Text] [Related]  

  • 9. X-ray structure of a novel matrix metalloproteinase inhibitor complexed to stromelysin.
    Dunten P; Kammlott U; Crowther R; Levin W; Foley LH; Wang P; Palermo R
    Protein Sci; 2001 May; 10(5):923-6. PubMed ID: 11316871
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor.
    Nar H; Werle K; Bauer MM; Dollinger H; Jung B
    J Mol Biol; 2001 Sep; 312(4):743-51. PubMed ID: 11575929
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Bioactive conformation of a potent stromelysin inhibitor determined by X-nucleus filtered and multidimensional NMR spectroscopy.
    Gonnella NC; Li YC; Zhang X; Paris CG
    Bioorg Med Chem; 1997 Dec; 5(12):2193-201. PubMed ID: 9459017
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural characterizations of nonpeptidic thiadiazole inhibitors of matrix metalloproteinases reveal the basis for stromelysin selectivity.
    Finzel BC; Baldwin ET; Bryant GL; Hess GF; Wilks JW; Trepod CM; Mott JE; Marshall VP; Petzold GL; Poorman RA; O'Sullivan TJ; Schostarez HJ; Mitchell MA
    Protein Sci; 1998 Oct; 7(10):2118-26. PubMed ID: 9792098
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The NMR structure of the inhibited catalytic domain of human stromelysin-1.
    Gooley PR; O'Connell JF; Marcy AI; Cuca GC; Salowe SP; Bush BL; Hermes JD; Esser CK; Hagmann WK; Springer JP
    Nat Struct Biol; 1994 Feb; 1(2):111-8. PubMed ID: 7656014
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The intermediate S1' pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling.
    Park HI; Jin Y; Hurst DR; Monroe CA; Lee S; Schwartz MA; Sang QX
    J Biol Chem; 2003 Dec; 278(51):51646-53. PubMed ID: 14532275
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition.
    Brandstetter H; Grams F; Glitz D; Lang A; Huber R; Bode W; Krell HW; Engh RA
    J Biol Chem; 2001 May; 276(20):17405-12. PubMed ID: 11278347
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases.
    Jacobson IC; Reddy PG; Wasserman ZR; Hardman KD; Covington MB; Arner EC; Copeland RA; Decicco CP; Magolda RL
    Bioorg Med Chem Lett; 1998 Apr; 8(7):837-42. PubMed ID: 9871551
    [TBL] [Abstract][Full Text] [Related]  

  • 17. X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity.
    Pavlovsky AG; Williams MG; Ye QZ; Ortwine DF; Purchase CF; White AD; Dhanaraj V; Roth BD; Johnson LL; Hupe D; Humblet C; Blundell TL
    Protein Sci; 1999 Jul; 8(7):1455-62. PubMed ID: 10422833
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure of full-length porcine synovial collagenase reveals a C-terminal domain containing a calcium-linked, four-bladed beta-propeller.
    Li J; Brick P; O'Hare MC; Skarzynski T; Lloyd LF; Curry VA; Clark IM; Bigg HF; Hazleman BL; Cawston TE
    Structure; 1995 Jun; 3(6):541-9. PubMed ID: 8590015
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Solution structures of stromelysin complexed to thiadiazole inhibitors.
    Stockman BJ; Waldon DJ; Gates JA; Scahill TA; Kloosterman DA; Mizsak SA; Jacobsen EJ; Belonga KL; Mitchell MA; Mao B; Petke JD; Goodman L; Powers EA; Ledbetter SR; Kaytes PS; Vogeli G; Marshall VP; Petzold GL; Poorman RA
    Protein Sci; 1998 Nov; 7(11):2281-6. PubMed ID: 9827994
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure of the catalytic domain of human fibroblast collagenase complexed with an inhibitor.
    Borkakoti N; Winkler FK; Williams DH; D'Arcy A; Broadhurst MJ; Brown PA; Johnson WH; Murray EJ
    Nat Struct Biol; 1994 Feb; 1(2):106-10. PubMed ID: 7656013
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.