BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

198 related articles for article (PubMed ID: 8747433)

  • 1. Structural effects of the binding of GTP to the wild-type and oncogenic forms of the ras-gene-encoded p21 proteins.
    Monaco R; Chen JM; Friedman FK; Brandt-Rauf P; Chung D; Pincus MR
    J Protein Chem; 1995 Nov; 14(8):721-9. PubMed ID: 8747433
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Comparison of the low energy conformations of an oncogenic and a non-oncogenic p21 protein, neither of which binds GTP or GDP.
    Liwo A; Gibson KD; Scheraga HA; Brandt-Rauf PW; Monaco R; Pincus MR
    J Protein Chem; 1994 Feb; 13(2):237-51. PubMed ID: 8060496
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Comparison of the average structures, from molecular dynamics, of complexes of GTPase activating protein (GAP) with oncogenic and wild-type ras-p21: identification of potential effector domains.
    Chen JM; Friedman FK; Brandt-Rauf PW; Pincus MR; Chie L
    J Protein Chem; 2002 Jul; 21(5):349-59. PubMed ID: 12206509
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Comparison of the computed three-dimensional structures of oncogenic forms (bound to GDP) of the ras-gene-encoded p21 protein with the structure of the normal (non-transforming) wild-type protein.
    Monaco R; Chen JM; Chung D; Brandt-Rauf P; Pincus MR
    J Protein Chem; 1995 Aug; 14(6):457-66. PubMed ID: 8593186
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification, using molecular dynamics, of an effector domain of the ras-binding domain of the raf-p74 protein that is uniquely involved in oncogenic ras-p21 signaling.
    Chen JM; Rijhwani K; Friedman FK; Hyde MJ; Pincus MR
    J Protein Chem; 2000 Oct; 19(7):545-51. PubMed ID: 11233167
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Oncogenic amino acid substitutions in the inhibitory rap-1A protein cause it to adopt a ras-p21-like conformation as computed using molecular dynamics.
    Chen JM; Brandt-Rauf PW; Pincus MR
    J Biomol Struct Dyn; 1996 Jun; 13(6):925-33. PubMed ID: 8832375
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Comparison of ras-p21 bound to GDP and GTP: differences in protein and ligand dynamics.
    Mello LV; van Aalten DM; Findlay JB
    Protein Eng; 1997 Apr; 10(4):381-7. PubMed ID: 9194162
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Comparison of molecular dynamics averaged structures for complexes of normal and oncogenic ras-p21 with SOS nucleotide exchange protein, containing computed conformations for three crystallographically undefined domains, suggests a potential role of these domains in ras signaling.
    Duncan T; Chen JM; Friedman FK; Hyde M; Chie L; Pincus MR
    Protein J; 2004 Apr; 23(3):217-28. PubMed ID: 15200053
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Activated conformations of the ras-gene-encoded p21 protein. 2. Comparison of the computed and high-resolution x-ray crystallographic structures of Gly-12 p21.
    Dykes DC; Brandt-Rauf P; Luster SM; Friedman FK; Pincus MR
    J Biomol Struct Dyn; 1993 Apr; 10(5):905-18. PubMed ID: 8318164
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Crystal structures at 2.2 A resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP.
    Tong LA; de Vos AM; Milburn MV; Kim SH
    J Mol Biol; 1991 Feb; 217(3):503-16. PubMed ID: 1899707
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular dynamics of the H-ras gene-encoded p21 protein; identification of flexible regions and possible effector domains.
    Dykes DC; Friedman FK; Dykes SL; Murphy RB; Brandt-Rauf PW; Pincus MR
    J Biomol Struct Dyn; 1993 Dec; 11(3):443-58. PubMed ID: 8129867
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Molecular dynamics simulation of the solution structures of Ha-ras-p21 GDP and GTP complexes: flexibility, possible hinges, and levers of the conformational transition.
    Díaz JF; Wroblowski B; Engelborghs Y
    Biochemistry; 1995 Sep; 34(37):12038-47. PubMed ID: 7547942
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Development of new anti-cancer peptides from conformational energy analysis of the oncogenic ras-p21 protein and its complexes with target proteins.
    Pincus MR
    Front Biosci; 2004 Sep; 9():3486-509. PubMed ID: 15353372
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Electrostatic control of GTP and GDP binding in the oncoprotein p21ras.
    Muegge I; Schweins T; Langen R; Warshel A
    Structure; 1996 Apr; 4(4):475-89. PubMed ID: 8740369
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The hydration of Ras p21 in solution during GTP hydrolysis based on solution X-ray scattering profile.
    Fujisawa T; Uruga T; Yamaizumi Z; Inoko Y; Nishimura S; Ueki T
    J Biochem; 1994 May; 115(5):875-80. PubMed ID: 7961601
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Revisiting the structural flexibility of the complex p21(ras)-GTP: the catalytic conformation of the molecular switch II.
    Soares TA; Miller JH; Straatsma TP
    Proteins; 2001 Dec; 45(4):297-312. PubMed ID: 11746677
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Molecular dynamics analysis of the structures of ras-guanine nucleotide exchange protein (SOS) bound to wild-type and oncogenic ras-p21. Identification of effector domains of SOS.
    Chen JM; Friedman FK; Hyde MJ; Monaco R; Pincus MR
    J Protein Chem; 1999 Nov; 18(8):867-74. PubMed ID: 10839623
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Ligand-induced conformational changes in ras p21: a normal mode and energy minimization analysis.
    Ma J; Karplus M
    J Mol Biol; 1997 Nov; 274(1):114-31. PubMed ID: 9398520
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Three-dimensional structure of p21 in the active conformation and analysis of an oncogenic mutant.
    Wittinghofer F; Krengel U; John J; Kabsch W; Pai EF
    Environ Health Perspect; 1991 Jun; 93():11-5. PubMed ID: 1773783
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Three-dimensional structure and properties of wild-type and mutant H-ras-encoded p21.
    Wittinghofer A; Franken SM; Scheidig AJ; Rensland H; Lautwein A; Pai EF; Goody RS
    Ciba Found Symp; 1993; 176():6-21; discussion 21-7. PubMed ID: 8299426
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.