These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

171 related articles for article (PubMed ID: 8750925)

  • 1. Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans.
    Busse D; Cosme J; Beaune P; Kroemer HK; Eichelbaum M
    Naunyn Schmiedebergs Arch Pharmacol; 1995 Dec; 353(1):116-21. PubMed ID: 8750925
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification of P450 enzymes involved in metabolism of verapamil in humans.
    Kroemer HK; Gautier JC; Beaune P; Henderson C; Wolf CR; Eichelbaum M
    Naunyn Schmiedebergs Arch Pharmacol; 1993 Sep; 348(3):332-7. PubMed ID: 8232610
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Regiochemistry and substrate stereoselectivity of O-demethylation of verapamil in the presence of the microsomal fraction from rat and human liver.
    Nelson WL; Olsen LD; Beitner DB; Pallow RJ
    Drug Metab Dispos; 1988; 16(2):184-8. PubMed ID: 2898330
    [TBL] [Abstract][Full Text] [Related]  

  • 4. CYP2C subfamily, primarily CYP2C9, catalyses the enantioselective demethylation of the endocrine disruptor pesticide methoxychlor in human liver microsomes: use of inhibitory monoclonal antibodies in P450 identification.
    Hu Y; Krausz K; Gelboin HV; Kupfer D
    Xenobiotica; 2004 Feb; 34(2):117-32. PubMed ID: 14985143
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites.
    Sutton D; Butler AM; Nadin L; Murray M
    J Pharmacol Exp Ther; 1997 Jul; 282(1):294-300. PubMed ID: 9223567
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cytochrome P450 2C9 catalyzes indomethacin O-demethylation in human liver microsomes.
    Nakajima M; Inoue T; Shimada N; Tokudome S; Yamamoto T; Kuroiwa Y
    Drug Metab Dispos; 1998 Mar; 26(3):261-6. PubMed ID: 9492390
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification and characterization of the cytochrome P450 enzymes involved in N-dealkylation of propafenone: molecular base for interaction potential and variable disposition of active metabolites.
    Botsch S; Gautier JC; Beaune P; Eichelbaum M; Kroemer HK
    Mol Pharmacol; 1993 Jan; 43(1):120-6. PubMed ID: 8423765
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cytochromes P450, 1A2, and 2C9 are responsible for the human hepatic O-demethylation of R- and S-naproxen.
    Miners JO; Coulter S; Tukey RH; Veronese ME; Birkett DJ
    Biochem Pharmacol; 1996 Apr; 51(8):1003-8. PubMed ID: 8866821
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Differential enantioselectivity and product-dependent activation and inhibition in metabolism of verapamil by human CYP3As.
    Shen L; Fitzloff JF; Cook CS
    Drug Metab Dispos; 2004 Feb; 32(2):186-96. PubMed ID: 14744940
    [TBL] [Abstract][Full Text] [Related]  

  • 10. [O-methyl 14C]naproxen O-demethylase activity in human liver microsomes: evidence for the involvement of cytochrome P4501A2 and P4502C9/10.
    Rodrigues AD; Kukulka MJ; Roberts EM; Ouellet D; Rodgers TR
    Drug Metab Dispos; 1996 Jan; 24(1):126-36. PubMed ID: 8825200
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Involvement of multiple cytochrome P450 isoforms in naproxen O-demethylation.
    Tracy TS; Marra C; Wrighton SA; Gonzalez FJ; Korzekwa KR
    Eur J Clin Pharmacol; 1997; 52(4):293-8. PubMed ID: 9248768
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Human cytochrome P450-catalyzed conversion of the proestrogenic pesticide methoxychlor into an estrogen. Role of CYP2C19 and CYP1A2 in O-demethylation.
    Stresser DM; Kupfer D
    Drug Metab Dispos; 1998 Sep; 26(9):868-74. PubMed ID: 9733665
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation.
    Engel G; Hofmann U; Heidemann H; Cosme J; Eichelbaum M
    Clin Pharmacol Ther; 1996 Jun; 59(6):613-23. PubMed ID: 8681486
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Characterization of dextromethorphan N-demethylation by human liver microsomes. Contribution of the cytochrome P450 3A (CYP3A) subfamily.
    Gorski JC; Jones DR; Wrighton SA; Hall SD
    Biochem Pharmacol; 1994 Jul; 48(1):173-82. PubMed ID: 8043020
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis of sulfaphenazole derivatives and their use as inhibitors and tools for comparing the active sites of human liver cytochromes P450 of the 2C subfamily.
    Ha-Duong NT; Dijols S; Marques-Soares C; Minoletti C; Dansette PM; Mansuy D
    J Med Chem; 2001 Oct; 44(22):3622-31. PubMed ID: 11606127
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Rapid and highly sensitive method for the determination of verapamil, [2H7]verapamil and metabolites in biological fluids by liquid chromatography-mass spectrometry.
    von Richter O; Eichelbaum M; Schönberger F; Hofmann U
    J Chromatogr B Biomed Sci Appl; 2000 Jan; 738(1):137-47. PubMed ID: 10778935
    [TBL] [Abstract][Full Text] [Related]  

  • 17. In vitro sulfoxidation of thioether compounds by human cytochrome P450 and flavin-containing monooxygenase isoforms with particular reference to the CYP2C subfamily.
    Usmani KA; Karoly ED; Hodgson E; Rose RL
    Drug Metab Dispos; 2004 Mar; 32(3):333-9. PubMed ID: 14977868
    [TBL] [Abstract][Full Text] [Related]  

  • 18. (R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes.
    Margolis JM; O'Donnell JP; Mankowski DC; Ekins S; Obach RS
    Drug Metab Dispos; 2000 Oct; 28(10):1187-91. PubMed ID: 10997938
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Characterization of the cytochrome P450 isoenzymes involved in the in vitro N-dealkylation of haloperidol.
    Pan LP; Wijnant P; De Vriendt C; Rosseel MT; Belpaire FM
    Br J Clin Pharmacol; 1997 Dec; 44(6):557-64. PubMed ID: 9431831
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cytochrome P-450 enzymes and FMO3 contribute to the disposition of the antipsychotic drug perazine in vitro.
    Störmer E; Brockmöller J; Roots I; Schmider J
    Psychopharmacology (Berl); 2000 Sep; 151(4):312-20. PubMed ID: 11026737
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.