171 related articles for article (PubMed ID: 8807052)
1. Kinetics of Plasmodium falciparum thymidylate synthase: interactions with high-affinity metabolites of 5-fluoroorotate and D1694.
Hekmat-Nejad M; Rathod PK
Antimicrob Agents Chemother; 1996 Jul; 40(7):1628-32. PubMed ID: 8807052
[TBL] [Abstract][Full Text] [Related]
2. Susceptibility of Plasmodium falciparum to a combination of thymidine and ICI D1694, a quinazoline antifolate directed at thymidylate synthase.
Rathod PK; Reshmi S
Antimicrob Agents Chemother; 1994 Mar; 38(3):476-80. PubMed ID: 8203840
[TBL] [Abstract][Full Text] [Related]
3. Molecular targets of 5-fluoroorotate in the human malaria parasite, Plasmodium falciparum.
Rathod PK; Leffers NP; Young RD
Antimicrob Agents Chemother; 1992 Apr; 36(4):704-11. PubMed ID: 1503432
[TBL] [Abstract][Full Text] [Related]
4. ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.
Jackman AL; Taylor GA; Gibson W; Kimbell R; Brown M; Calvert AH; Judson IR; Hughes LR
Cancer Res; 1991 Oct; 51(20):5579-86. PubMed ID: 1913676
[TBL] [Abstract][Full Text] [Related]
5. Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparum.
Jiang L; Lee PC; White J; Rathod PK
Antimicrob Agents Chemother; 2000 Apr; 44(4):1047-50. PubMed ID: 10722510
[TBL] [Abstract][Full Text] [Related]
6. Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro.
Rathod PK; Khatri A; Hubbert T; Milhous WK
Antimicrob Agents Chemother; 1989 Jul; 33(7):1090-4. PubMed ID: 2675756
[TBL] [Abstract][Full Text] [Related]
7. Clonal viability measurements on Plasmodium falciparum to assess in vitro schizonticidal activity of leupeptin, chloroquine, and 5-fluoroorotate.
Young RD; Rathod PK
Antimicrob Agents Chemother; 1993 May; 37(5):1102-7. PubMed ID: 8517698
[TBL] [Abstract][Full Text] [Related]
8. Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase.
Ward WH; Kimbell R; Jackman AL
Biochem Pharmacol; 1992 May; 43(9):2029-31. PubMed ID: 1596289
[TBL] [Abstract][Full Text] [Related]
9. Isolation and characterization of thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells.
Tong Y; Liu-Chen X; Ercikan-Abali EA; Capiaux GM; Zhao SC; Banerjee D; Bertino JR
J Biol Chem; 1998 May; 273(19):11611-8. PubMed ID: 9565579
[TBL] [Abstract][Full Text] [Related]
10. The thymidylate synthase inhibitor, ICI D1694, overcomes translational detainment of the enzyme.
Keyomarsi K; Samet J; Molnar G; Pardee AB
J Biol Chem; 1993 Jul; 268(20):15142-9. PubMed ID: 8325888
[TBL] [Abstract][Full Text] [Related]
11. The measurement of polyglutamate metabolites of the thymidylate synthase inhibitor, ICI D1694, in mouse and human cultured cells.
Gibson W; Bisset GM; Marsham PR; Kelland LR; Judson IR; Jackman AL
Biochem Pharmacol; 1993 Feb; 45(4):863-9. PubMed ID: 7680860
[TBL] [Abstract][Full Text] [Related]
12. Mode of binding of folate analogs to thymidylate synthase. Evidence for two asymmetric but interactive substrate binding sites.
Dev IK; Dallas WS; Ferone R; Hanlon M; McKee DD; Yates BB
J Biol Chem; 1994 Jan; 269(3):1873-82. PubMed ID: 8294436
[TBL] [Abstract][Full Text] [Related]
13. In vitro uptake, anabolism, and cellular retention of 1843U89 and other benzoquinazoline inhibitors of thymidylate synthase.
Hanlon MH; Ferone R
Cancer Res; 1996 Jul; 56(14):3301-6. PubMed ID: 8764125
[TBL] [Abstract][Full Text] [Related]
14. Malarial (Plasmodium falciparum) dihydrofolate reductase-thymidylate synthase: structural basis for antifolate resistance and development of effective inhibitors.
Yuthavong Y; Yuvaniyama J; Chitnumsub P; Vanichtanankul J; Chusacultanachai S; Tarnchompoo B; Vilaivan T; Kamchonwongpaisan S
Parasitology; 2005 Mar; 130(Pt 3):249-59. PubMed ID: 15796007
[TBL] [Abstract][Full Text] [Related]
15. Frequency of drug resistance in Plasmodium falciparum: a nonsynergistic combination of 5-fluoroorotate and atovaquone suppresses in vitro resistance.
Gassis S; Rathod PK
Antimicrob Agents Chemother; 1996 Apr; 40(4):914-9. PubMed ID: 8849251
[TBL] [Abstract][Full Text] [Related]
16. Trichinella spiralis thymidylate synthase: developmental pattern, isolation, molecular properties, and inhibition by substrate and cofactor analogues.
Dabrowska M; Zieliñski Z; Wranicz M; Michalski R; Pawelczak K; Rode W
Biochem Biophys Res Commun; 1996 Nov; 228(2):440-5. PubMed ID: 8920932
[TBL] [Abstract][Full Text] [Related]
17. Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition.
Bijnsdorp IV; Comijn EM; Padron JM; Gmeiner WH; Peters GJ
Oncol Rep; 2007 Jul; 18(1):287-91. PubMed ID: 17549381
[TBL] [Abstract][Full Text] [Related]
18. Differential drug binding by the highly conserved Plasmodium falciparum thymidylate synthase.
Pang CK; De SK; White J; Buckner FS; Varani G; Rathod PK
Mol Biochem Parasitol; 2005 Sep; 143(1):121-4. PubMed ID: 15978681
[No Abstract] [Full Text] [Related]
19. Thymidylate synthase as a target in cancer chemotherapy.
Peters GJ; van der Wilt CL
Biochem Soc Trans; 1995 Nov; 23(4):884-8. PubMed ID: 8654859
[No Abstract] [Full Text] [Related]
20. Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP.
Almog R; Waddling CA; Maley F; Maley GF; Van Roey P
Protein Sci; 2001 May; 10(5):988-96. PubMed ID: 11316879
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
