These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

111 related articles for article (PubMed ID: 8824765)

  • 1. Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: molecular basis for the antiviral activity of unnatural L-beta-nucleosides.
    Spadari S; Maga G; Verri A; Bendiscioli A; Tondelli L; Capobianco M; Colonna F; Garbesi A; Focher F
    Biochimie; 1995; 77(11):861-67. PubMed ID: 8824765
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5'-triphosphate as substrate.
    Focher F; Maga G; Bendiscioli A; Capobianco M; Colonna F; Garbesi A; Spadari S
    Nucleic Acids Res; 1995 Aug; 23(15):2840-7. PubMed ID: 7544886
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Molecular basis for the antiviral and anticancer activities of unnatural L-beta-nucleosides.
    Spadari S; Maga G; Verri A; Focher F
    Expert Opin Investig Drugs; 1998 Aug; 7(8):1285-300. PubMed ID: 15992031
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Guanine α-carboxy nucleoside phosphonate (G-α-CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses.
    Balzarini J; Menni M; Das K; van Berckelaer L; Ford A; Maguire NM; Liekens S; Boehmer PE; Arnold E; Götte M; Maguire AR
    Biochem Pharmacol; 2017 Jul; 136():51-61. PubMed ID: 28390939
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The enantioselectivity of enzymes involved in current antiviral therapy using nucleoside analogues: a new strategy?
    Maury G
    Antivir Chem Chemother; 2000 May; 11(3):165-89. PubMed ID: 10901289
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Stereoisomeric selectivity of human deoxyribonucleoside kinases.
    Wang J; Choudhury D; Chattopadhyaya J; Eriksson S
    Biochemistry; 1999 Dec; 38(51):16993-9. PubMed ID: 10606535
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
    Gardberg A; Shuvalova L; Monnerjahn C; Konrad M; Lavie A
    Structure; 2003 Oct; 11(10):1265-77. PubMed ID: 14527394
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Lack of stereospecificity of suid pseudorabies virus thymidine kinase.
    Maga G; Verri A; Bonizzi L; Ponti W; Poli G; Garbesi A; Niccolai D; Spadari S; Focher F
    Biochem J; 1993 Sep; 294 ( Pt 2)(Pt 2):381-5. PubMed ID: 8396911
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase.
    Sienaert R; Naesens L; Brancale A; De Clercq E; McGuigan C; Balzarini J
    Mol Pharmacol; 2002 Feb; 61(2):249-54. PubMed ID: 11809847
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and in vitro activity of D- and L-enantiomers of 5-(trifluoromethyl)uracil nucleoside derivatives.
    Salvetti R; Pregnolato M; Verri A; Focher F; Spadari S; Marchand A; Mathé C; Gosselin G
    Nucleosides Nucleotides Nucleic Acids; 2001; 20(4-7):1123-5. PubMed ID: 11562969
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Enzymatic phosphorylation of unnatural nucleosides.
    Wu Y; Fa M; Tae EL; Schultz PG; Romesberg FE
    J Am Chem Soc; 2002 Dec; 124(49):14626-30. PubMed ID: 12465973
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes.
    Verri A; Focher F; Duncombe RJ; Basnak I; Walker RT; Coe PL; de Clercq E; Andrei G; Snoeck R; Balzarini J; Spadari S
    Biochem J; 2000 Oct; 351 Pt 2(Pt 2):319-26. PubMed ID: 11023816
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates.
    Topalis D; Pradère U; Roy V; Caillat C; Azzouzi A; Broggi J; Snoeck R; Andrei G; Lin J; Eriksson S; Alexandre JA; El-Amri C; Deville-Bonne D; Meyer P; Balzarini J; Agrofoglio LA
    J Med Chem; 2011 Jan; 54(1):222-32. PubMed ID: 21128666
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Nucleoside binding site of herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography.
    Vogt J; Perozzo R; Pautsch A; Prota A; Schelling P; Pilger B; Folkers G; Scapozza L; Schulz GE
    Proteins; 2000 Dec; 41(4):545-53. PubMed ID: 11056041
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Kinetic studies with N2-phenylguanines and with L-thymidine indicate that herpes simplex virus type-1 thymidine kinase and thymidylate kinase share a common active site.
    Maga G; Focher F; Wright GE; Capobianco M; Garbesi A; Bendiscioli A; Spadari S
    Biochem J; 1994 Aug; 302 ( Pt 1)(Pt 1):279-82. PubMed ID: 8068016
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Experimental and structural evidence that herpes 1 kinase and cellular DNA polymerase(s) discriminate on the basis of sugar pucker.
    Marquez VE; Ben-Kasus T; Barchi JJ; Green KM; Nicklaus MC; Agbaria R
    J Am Chem Soc; 2004 Jan; 126(2):543-9. PubMed ID: 14719951
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Research on L-nucleosides. Synthesis and biological evaluation of a series of L- and D-2',3'-dideoxy-3'-[tris(methylthio)methyl]-beta-pentofuranosyl nucleosides.
    Mugnaini C; Botta M; Coletta M; Corelli F; Focher F; Marini S; Renzulli ML; Verri A
    Bioorg Med Chem; 2003 Feb; 11(3):357-66. PubMed ID: 12517431
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and antiviral activity of novel acyclic nucleosides: discovery of a cyclopropyl nucleoside with potent inhibitory activity against herpesviruses.
    Sekiyama T; Hatsuya S; Tanaka Y; Uchiyama M; Ono N; Iwayama S; Oikawa M; Suzuki K; Okunishi M; Tsuji T
    J Med Chem; 1998 Apr; 41(8):1284-98. PubMed ID: 9548818
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Interactions between virus and antiviral compounds in the host cell.
    Harmenberg J
    Med Biol; 1984; 62(6):299-303. PubMed ID: 6099858
    [No Abstract]   [Full Text] [Related]  

  • 20. The role of thymidine kinases in the activation of pyrimidine nucleoside analogues.
    Al-Madhoun AS; Tjarks W; Eriksson S
    Mini Rev Med Chem; 2004 May; 4(4):341-50. PubMed ID: 15134537
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.