161 related articles for article (PubMed ID: 8836126)
1. Aging of phosphylated human acetylcholinesterase: catalytic processes mediated by aromatic and polar residues of the active centre.
Shafferman A; Ordentlich A; Barak D; Stein D; Ariel N; Velan B
Biochem J; 1996 Sep; 318 ( Pt 3)(Pt 3):833-40. PubMed ID: 8836126
[TBL] [Abstract][Full Text] [Related]
2. Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers.
Ordentlich A; Barak D; Kronman C; Benschop HP; De Jong LP; Ariel N; Barak R; Segall Y; Velan B; Shafferman A
Biochemistry; 1999 Mar; 38(10):3055-66. PubMed ID: 10074358
[TBL] [Abstract][Full Text] [Related]
3. Engineering resistance to 'aging' of phosphylated human acetylcholinesterase. Role of hydrogen bond network in the active center.
Ordentlich A; Kronman C; Barak D; Stein D; Ariel N; Marcus D; Velan B; Shafferman A
FEBS Lett; 1993 Nov; 334(2):215-20. PubMed ID: 8224249
[TBL] [Abstract][Full Text] [Related]
4. Functional requirements for the optimal catalytic configuration of the AChE active center.
Shafferman A; Barak D; Kaplan D; Ordentlich A; Kronman C; Velan B
Chem Biol Interact; 2005 Dec; 157-158():123-31. PubMed ID: 16256968
[TBL] [Abstract][Full Text] [Related]
5. The aromatic "trapping" of the catalytic histidine is essential for efficient catalysis in acetylcholinesterase.
Barak D; Kaplan D; Ordentlich A; Ariel N; Velan B; Shafferman A
Biochemistry; 2002 Jul; 41(26):8245-52. PubMed ID: 12081473
[TBL] [Abstract][Full Text] [Related]
6. Is aromaticity essential for trapping the catalytic histidine 447 in human acetylcholinesterase?
Kaplan D; Barak D; Ordentlich A; Kronman C; Velan B; Shafferman A
Biochemistry; 2004 Mar; 43(11):3129-36. PubMed ID: 15023064
[TBL] [Abstract][Full Text] [Related]
7. Hydration change during the aging of phosphorylated human butyrylcholinesterase: importance of residues aspartate-70 and glutamate-197 in the water network as probed by hydrostatic and osmotic pressures.
Masson P; Cléry C; Guerra P; Redslob A; Albaret C; Fortier PL
Biochem J; 1999 Oct; 343 Pt 2(Pt 2):361-9. PubMed ID: 10510301
[TBL] [Abstract][Full Text] [Related]
8. Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase.
Ordentlich A; Barak D; Kronman C; Ariel N; Segall Y; Velan B; Shafferman A
J Biol Chem; 1995 Feb; 270(5):2082-91. PubMed ID: 7836436
[TBL] [Abstract][Full Text] [Related]
9. Acetylcholinesterase active centre and gorge conformations analysed by combinatorial mutations and enantiomeric phosphonates.
Kovarik Z; Radić Z; Berman HA; Simeon-Rudolf V; Reiner E; Taylor P
Biochem J; 2003 Jul; 373(Pt 1):33-40. PubMed ID: 12665427
[TBL] [Abstract][Full Text] [Related]
10. Aging of di-isopropyl-phosphorylated human butyrylcholinesterase.
Masson P; Fortier PL; Albaret C; Froment MT; Bartels CF; Lockridge O
Biochem J; 1997 Oct; 327 ( Pt 2)(Pt 2):601-7. PubMed ID: 9359435
[TBL] [Abstract][Full Text] [Related]
11. Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core.
Barak D; Kronman C; Ordentlich A; Ariel N; Bromberg A; Marcus D; Lazar A; Velan B; Shafferman A
J Biol Chem; 1994 Mar; 269(9):6296-305. PubMed ID: 8119978
[TBL] [Abstract][Full Text] [Related]
12. Short, strong hydrogen bonds at the active site of human acetylcholinesterase: proton NMR studies.
Massiah MA; Viragh C; Reddy PM; Kovach IM; Johnson J; Rosenberry TL; Mildvan AS
Biochemistry; 2001 May; 40(19):5682-90. PubMed ID: 11341833
[TBL] [Abstract][Full Text] [Related]
13. The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors.
Ariel N; Ordentlich A; Barak D; Bino T; Velan B; Shafferman A
Biochem J; 1998 Oct; 335 ( Pt 1)(Pt 1):95-102. PubMed ID: 9742217
[TBL] [Abstract][Full Text] [Related]
14. Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket.
Ordentlich A; Barak D; Kronman C; Flashner Y; Leitner M; Segall Y; Ariel N; Cohen S; Velan B; Shafferman A
J Biol Chem; 1993 Aug; 268(23):17083-95. PubMed ID: 8349597
[TBL] [Abstract][Full Text] [Related]
15. Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding.
Shafferman A; Kronman C; Flashner Y; Leitner M; Grosfeld H; Ordentlich A; Gozes Y; Cohen S; Ariel N; Barak D
J Biol Chem; 1992 Sep; 267(25):17640-8. PubMed ID: 1517212
[TBL] [Abstract][Full Text] [Related]
16. Evidence for P-N bond scission in phosphoroamidate nerve agent adducts of human acetylcholinesterase.
Barak D; Ordentlich A; Kaplan D; Barak R; Mizrahi D; Kronman C; Segall Y; Velan B; Shafferman A
Biochemistry; 2000 Feb; 39(5):1156-61. PubMed ID: 10653663
[TBL] [Abstract][Full Text] [Related]
17. The architecture of human acetylcholinesterase active center probed by interactions with selected organophosphate inhibitors.
Ordentlich A; Barak D; Kronman C; Ariel N; Segall Y; Velan B; Shafferman A
J Biol Chem; 1996 May; 271(20):11953-62. PubMed ID: 8662593
[TBL] [Abstract][Full Text] [Related]
18. The pH dependence of dealkylation in soman-inhibited cholinesterases and their mutants: further evidence for a push-pull mechanism.
Saxena A; Viragh C; Frazier DS; Kovach IM; Maxwell DM; Lockridge O; Doctor BP
Biochemistry; 1998 Oct; 37(43):15086-96. PubMed ID: 9790671
[TBL] [Abstract][Full Text] [Related]
19. Direct determination of the chemical composition of acetylcholinesterase phosphonylation products utilizing electrospray-ionization mass spectrometry.
Barak R; Ordentlich A; Barak D; Fischer M; Benschop HP; De Jong LP; Segall Y; Velan B; Shafferman A
FEBS Lett; 1997 May; 407(3):347-52. PubMed ID: 9175882
[TBL] [Abstract][Full Text] [Related]
20. Aging-resistant organophosphate bioscavenger based on polyethylene glycol-conjugated F338A human acetylcholinesterase.
Mazor O; Cohen O; Kronman C; Raveh L; Stein D; Ordentlich A; Shafferman A
Mol Pharmacol; 2008 Sep; 74(3):755-63. PubMed ID: 18523134
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
