236 related articles for article (PubMed ID: 8849323)
1. Inhibition of voltage-gated Ca2+ channel activity in small cell lung carcinoma by the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperaz ine) .
Williams CL; Porter RA; Phelps SH
Biochem Pharmacol; 1995 Dec; 50(12):1979-85. PubMed ID: 8849323
[TBL] [Abstract][Full Text] [Related]
2. Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cell lung carcinoma.
Williams CL; Phelps SH; Porter RA
Biochem Pharmacol; 1996 Mar; 51(5):707-15. PubMed ID: 8615909
[TBL] [Abstract][Full Text] [Related]
3. Inhibition of M3 muscarinic acetylcholine receptor-mediated Ca2+ influx and intracellular Ca2+ mobilization in neuroblastoma cells by the Ca2+/calmodulin-dependent protein kinase inhibitor 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-trosyl]-4-phenylpiperazin e (KN-62).
Puhl HL; Raman PS; Williams CL; Aronstam RS
Biochem Pharmacol; 1997 Apr; 53(8):1107-14. PubMed ID: 9175715
[TBL] [Abstract][Full Text] [Related]
4. Inhibition of voltage-gated Ca2+ channels and insulin secretion in HIT cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-62: comparison with antagonists of calmodulin and L-type Ca2+ channels.
Li G; Hidaka H; Wollheim CB
Mol Pharmacol; 1992 Sep; 42(3):489-8. PubMed ID: 1328847
[TBL] [Abstract][Full Text] [Related]
5. KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.
Tokumitsu H; Chijiwa T; Hagiwara M; Mizutani A; Terasawa M; Hidaka H
J Biol Chem; 1990 Mar; 265(8):4315-20. PubMed ID: 2155222
[TBL] [Abstract][Full Text] [Related]
6. Ca(2+)/calmodulin-dependent protein kinase II inhibitor KN-62 inhibits adrenal medullary chromaffin cell functions independent of its action on the kinase.
Tsutsui M; Yanagihara N; Fukunaga K; Minami K; Nakashima Y; Kuroiwa A; Miyamoto E; Izumi F
J Neurochem; 1996 Jun; 66(6):2517-22. PubMed ID: 8632177
[TBL] [Abstract][Full Text] [Related]
7. Activation of M3 muscarinic acetylcholine receptors inhibits voltage-dependent calcium influx in small cell lung carcinoma.
Williams CL; Lennon VA
J Biol Chem; 1990 Jan; 265(3):1443-7. PubMed ID: 2153134
[TBL] [Abstract][Full Text] [Related]
8. Effects of protein kinase inhibitors on morphology and function of cultured bovine adrenal chromaffin cells: KN-62 inhibits secretory function by blocking stimulated Ca2+ entry.
Maurer JA; Wenger BW; McKay DB
J Neurochem; 1996 Jan; 66(1):105-13. PubMed ID: 8522941
[TBL] [Abstract][Full Text] [Related]
9. Mechanism of catecholamine synthesis inhibition by neuropeptide Y: role of Ca2+ channels and protein kinases.
McCullough LA; Westfall TC
J Neurochem; 1996 Sep; 67(3):1090-9. PubMed ID: 8752116
[TBL] [Abstract][Full Text] [Related]
10. Inhibition of regulated catecholamine secretion from PC12 cells by the Ca2+/calmodulin kinase II inhibitor KN-62.
Schweitzer ES; Sanderson MJ; Wasterlain CG
J Cell Sci; 1995 Jul; 108 ( Pt 7)():2619-28. PubMed ID: 7593303
[TBL] [Abstract][Full Text] [Related]
11. Dependence of insulin secretion from permeabilized pancreatic beta-cells on the activation of Ca(2+)/calmodulin-dependent protein kinase II. A re-evaluation of inhibitor studies.
Bhatt HS; Conner BP; Prasanna G; Yorio T; Easom RA
Biochem Pharmacol; 2000 Dec; 60(11):1655-63. PubMed ID: 11077048
[TBL] [Abstract][Full Text] [Related]
12. The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes.
Gargett CE; Wiley JS
Br J Pharmacol; 1997 Apr; 120(8):1483-90. PubMed ID: 9113369
[TBL] [Abstract][Full Text] [Related]
13. A selective Ca2+/calmodulin-dependent protein kinase II inhibitor, KN-62, inhibits the enhanced phosphorylation and the activation of tyrosine hydroxylase by 56 mM K+ in rat pheochromocytoma PC12h cells.
Ishii A; Kiuchi K; Kobayashi R; Sumi M; Hidaka H; Nagatsu T
Biochem Biophys Res Commun; 1991 May; 176(3):1051-6. PubMed ID: 1674865
[TBL] [Abstract][Full Text] [Related]
14. KN-62, a specific Ca++/calmodulin-dependent protein kinase inhibitor, reversibly depresses the rate of beating of cultured fetal mouse cardiac myocytes.
Okazaki K; Ishikawa T; Inui M; Tada M; Goshima K; Okamoto T; Hidaka H
J Pharmacol Exp Ther; 1994 Sep; 270(3):1319-24. PubMed ID: 7932185
[TBL] [Abstract][Full Text] [Related]
15. Effect of a new Ca2(+)-calmodulin-dependent protein kinase II inhibitor on GABA release in cerebrospinal fluid of the rat.
Ishikawa N; Hashiba Y; Hidaka H
J Pharmacol Exp Ther; 1990 Aug; 254(2):598-602. PubMed ID: 2384887
[TBL] [Abstract][Full Text] [Related]
16. Intracellular application of calmidazolium increases Ca2+ current through activation of protein kinase A in cultured vascular smooth muscle cells.
Sunagawa M; Yokoshiki H; Seki T; Sperelakis N
J Vasc Res; 1998; 35(5):303-9. PubMed ID: 9789110
[TBL] [Abstract][Full Text] [Related]
17. The effect of KN-62, Ca2+/calmodulin dependent protein kinase II inhibitor on cell cycle.
Minami H; Inoue S; Hidaka H
Biochem Biophys Res Commun; 1994 Feb; 199(1):241-8. PubMed ID: 8123019
[TBL] [Abstract][Full Text] [Related]
18. KN-62, a calcium/calmodulin-dependent protein kinase II inhibitor, inhibits high potassium-stimulated prolactin secretion and intracellular calcium increases in anterior pituitary cells.
Cui ZJ; Hidaka H; Dannies PS
Biochim Biophys Acta; 1996 Feb; 1310(3):343-7. PubMed ID: 8599613
[TBL] [Abstract][Full Text] [Related]
19. Effect of KN-62, Ca2+/calmodulin-dependent protein kinase II inhibitor, on adriamycin resistance of human ovarian cancer cells.
Obata NH; Okazaki K; Maeda O; Kikkawa F; Tomoda Y; Hidaka H
Biochem Biophys Res Commun; 1995 Oct; 215(2):566-71. PubMed ID: 7487993
[TBL] [Abstract][Full Text] [Related]
20. 1-[N, O-bis-(5-isoquinolinesulphonyl)-N-methyl-L-tyrosyl]-4- phenylpiperazine (KN-62), an inhibitor of calcium-dependent camodulin protein kinase II, inhibits both insulin- and hypoxia-stimulated glucose transport in skeletal muscle.
Brozinick JT; Reynolds TH; Dean D; Cartee G; Cushman SW
Biochem J; 1999 May; 339 ( Pt 3)(Pt 3):533-40. PubMed ID: 10215590
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]