BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

242 related articles for article (PubMed ID: 8857546)

  • 1. Individualizing therapy with 6-mercaptopurine and 6-thioguanine related to the thiopurine methyltransferase genetic polymorphism.
    Lennard L; Lilleyman JS
    Ther Drug Monit; 1996 Aug; 18(4):328-34. PubMed ID: 8857546
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Thiopurine drugs in the treatment of childhood leukaemia: the influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity.
    Lennard L; Welch JC; Lilleyman JS
    Br J Clin Pharmacol; 1997 Nov; 44(5):455-61. PubMed ID: 9384462
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Thiopurine therapies: problems, complexities, and progress with monitoring thioguanine nucleotides.
    Duley JA; Florin TH
    Ther Drug Monit; 2005 Oct; 27(5):647-54. PubMed ID: 16175140
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Thiopurine methyltransferase genotype-phenotype discordance and thiopurine active metabolite formation in childhood acute lymphoblastic leukaemia.
    Lennard L; Cartwright CS; Wade R; Richards SM; Vora A
    Br J Clin Pharmacol; 2013 Jul; 76(1):125-36. PubMed ID: 23252716
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing.
    Relling MV; Gardner EE; Sandborn WJ; Schmiegelow K; Pui CH; Yee SW; Stein CM; Carrillo M; Evans WE; Klein TE;
    Clin Pharmacol Ther; 2011 Mar; 89(3):387-91. PubMed ID: 21270794
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells.
    Dervieux T; Blanco JG; Krynetski EY; Vanin EF; Roussel MF; Relling MV
    Cancer Res; 2001 Aug; 61(15):5810-6. PubMed ID: 11479220
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Clinical implications of thiopurine methyltransferase--optimization of drug dosage and potential drug interactions.
    Lennard L
    Ther Drug Monit; 1998 Oct; 20(5):527-31. PubMed ID: 9780130
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Recent advances in the pharmacogenomics of thiopurine methyltransferase.
    Coulthard SA; Hall AG
    Pharmacogenomics J; 2001; 1(4):254-61. PubMed ID: 11908768
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Thiopurine biology and pharmacology.
    Aarbakke J; Janka-Schaub G; Elion GB
    Trends Pharmacol Sci; 1997 Jan; 18(1):3-7. PubMed ID: 9114722
    [No Abstract]   [Full Text] [Related]  

  • 10. Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
    Gearry RB; Barclay ML
    J Gastroenterol Hepatol; 2005 Aug; 20(8):1149-57. PubMed ID: 16048561
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Differential role of thiopurine methyltransferase in the cytotoxic effects of 6-mercaptopurine and 6-thioguanine on human leukemia cells.
    Karim H; Ghalali A; Lafolie P; Vitols S; Fotoohi AK
    Biochem Biophys Res Commun; 2013 Jul; 437(2):280-6. PubMed ID: 23811272
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Possible implication of thiopurine S-methyltransferase in occurrence of infectious episodes during maintenance therapy for childhood lymphoblastic leukemia with mercaptopurine.
    Dervieux T; Médard Y; Verpillat P; Guigonis V; Duval M; Lescoeur B; Suciu S; Vilmer E; Jacqz-Aigrain E
    Leukemia; 2001 Nov; 15(11):1706-12. PubMed ID: 11681411
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Differences between children and adults in thiopurine methyltransferase activity and metabolite formation during thiopurine therapy: possible role of concomitant methotrexate.
    Pettersson B; Almer S; Albertioni F; Söderhäll S; Peterson C
    Ther Drug Monit; 2002 Jun; 24(3):351-8. PubMed ID: 12021625
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations.
    Lennard L; Van Loon JA; Lilleyman JS; Weinshilboum RM
    Clin Pharmacol Ther; 1987 Jan; 41(1):18-25. PubMed ID: 3467886
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Establishment of thiopurine S-methyltransferase gene knockdown in jurkat T-lymphocytes: an in vitro model of TPMT polymorphism.
    Misdaq M; Andag R; Oellerich M; Asif AR; von Ahsen N
    Ther Drug Monit; 2012 Oct; 34(5):584-92. PubMed ID: 22972540
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The thiopurines: an update.
    Coulthard S; Hogarth L
    Invest New Drugs; 2005 Dec; 23(6):523-32. PubMed ID: 16267626
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus.
    Relling MV; Hancock ML; Rivera GK; Sandlund JT; Ribeiro RC; Krynetski EY; Pui CH; Evans WE
    J Natl Cancer Inst; 1999 Dec; 91(23):2001-8. PubMed ID: 10580024
    [TBL] [Abstract][Full Text] [Related]  

  • 18. [Significance of TPMT activity and TGNs level detection for individualizing 6-mercaptopurine chemotherapy].
    Gu LJ; Ye QD; Liang AB; Zhao JC; Xue HL; Tang YN; Chen J; Ye YC
    Zhonghua Xue Ye Xue Za Zhi; 2003 Jan; 24(1):18-21. PubMed ID: 12679004
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Hypoxanthine guanine phosphoribosyltransferase activity is related to 6-thioguanine nucleotide concentrations and thiopurine-induced leukopenia in the treatment of inflammatory bowel disease.
    Ding L; Zhang FB; Liu H; Gao X; Bi HC; Wang XD; Chen BL; Zhang Y; Zhao LZ; Zhong GP; Hu PJ; Chen MH; Huang M
    Inflamm Bowel Dis; 2012 Jan; 18(1):63-73. PubMed ID: 21381155
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine.
    Hawwa AF; Millership JS; Collier PS; Vandenbroeck K; McCarthy A; Dempsey S; Cairns C; Collins J; Rodgers C; McElnay JC
    Br J Clin Pharmacol; 2008 Oct; 66(4):517-28. PubMed ID: 18662289
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.