BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

507 related articles for article (PubMed ID: 8873618)

  • 1. A change in the internal aldimine lysine (K42) in O-acetylserine sulfhydrylase to alanine indicates its importance in transimination and as a general base catalyst.
    Rege VD; Kredich NM; Tai CH; Karsten WE; Schnackerz KD; Cook PF
    Biochemistry; 1996 Oct; 35(41):13485-93. PubMed ID: 8873618
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Cysteine 42 is important for maintaining an integral active site for O-acetylserine sulfhydrylase resulting in the stabilization of the alpha-aminoacrylate intermediate.
    Tai CH; Yoon MY; Kim SK; Rege VD; Nalabolu SR; Kredich NM; Schnackerz KD; Cook PF
    Biochemistry; 1998 Jul; 37(30):10597-604. PubMed ID: 9692949
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure, mechanism, and conformational dynamics of O-acetylserine sulfhydrylase from Salmonella typhimurium: comparison of A and B isozymes.
    Chattopadhyay A; Meier M; Ivaninskii S; Burkhard P; Speroni F; Campanini B; Bettati S; Mozzarelli A; Rabeh WM; Li L; Cook PF
    Biochemistry; 2007 Jul; 46(28):8315-30. PubMed ID: 17583914
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Time-resolved fluorescence of O-acetylserine sulfhydrylase catalytic intermediates.
    Benci S; Vaccari S; Mozzarelli A; Cook PF
    Biochemistry; 1997 Dec; 36(49):15419-27. PubMed ID: 9398272
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Role of Histidine-152 in cofactor orientation in the PLP-dependent O-acetylserine sulfhydrylase reaction.
    Tai CH; Rabeh WM; Guan R; Schnackerz KD; Cook PF
    Arch Biochem Biophys; 2008 Apr; 472(2):115-25. PubMed ID: 18275838
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Formation of the alpha-aminoacrylate immediate limits the overall reaction catalyzed by O-acetylserine sulfhydrylase.
    Woehl EU; Tai CH; Dunn MF; Cook PF
    Biochemistry; 1996 Apr; 35(15):4776-83. PubMed ID: 8664267
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Tryptophan luminescence as a probe of enzyme conformation along the O-acetylserine sulfhydrylase reaction pathway.
    Strambini GB; Cioni P; Cook PF
    Biochemistry; 1996 Jun; 35(25):8392-400. PubMed ID: 8679597
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Resolution of pyridoxal 5'-phosphate from O-acetylserine sulfhydrylase from Salmonella typhimurium and reconstitution of apoenzyme with cofactor and cofactor analogues as a probe of the cofactor binding site.
    Schnackerz KD; Cook PF
    Arch Biochem Biophys; 1995 Dec; 324(1):71-7. PubMed ID: 7503562
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of the structural determinants for the stability of substrate and aminoacrylate external Schiff bases in O-acetylserine sulfhydrylase-A.
    Tian H; Guan R; Salsi E; Campanini B; Bettati S; Kumar VP; Karsten WE; Mozzarelli A; Cook PF
    Biochemistry; 2010 Jul; 49(29):6093-103. PubMed ID: 20550197
    [TBL] [Abstract][Full Text] [Related]  

  • 10. (31)P NMR studies of O-acetylserine sulfhydrylase-B from Salmonella typhimurium.
    Guan R; Nimmo SA; Schnackerz KD; Cook PF
    Arch Biochem Biophys; 2009 Jul; 487(2):85-90. PubMed ID: 19501038
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Visualization of PLP-bound intermediates in hemeless variants of human cystathionine beta-synthase: evidence that lysine 119 is a general base.
    Evande R; Ojha S; Banerjee R
    Arch Biochem Biophys; 2004 Jul; 427(2):188-96. PubMed ID: 15196993
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Characterization of the S272A,D site-directed mutations of O-acetylserine sulfhydrylase: involvement of the pyridine ring in the alpha,beta-elimination reaction.
    Daum S; Tai CH; Cook PF
    Biochemistry; 2003 Jan; 42(1):106-13. PubMed ID: 12515544
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Kinetic isotope effects as a probe of the beta-elimination reaction catalyzed by O-acetylserine sulfhydrylase.
    Hwang CC; Woehl EU; Minter DE; Dunn MF; Cook PF
    Biochemistry; 1996 May; 35(20):6358-65. PubMed ID: 8639581
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The imine-pyridine torsion of the pyridoxal 5'-phosphate Schiff base of aspartate aminotransferase lowers its pKa in the unliganded enzyme and is crucial for the successive increase in the pKa during catalysis.
    Hayashi H; Mizuguchi H; Kagamiyama H
    Biochemistry; 1998 Oct; 37(43):15076-85. PubMed ID: 9790670
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Ligand binding induces a large conformational change in O-acetylserine sulfhydrylase from Salmonella typhimurium.
    Burkhard P; Tai CH; Ristroph CM; Cook PF; Jansonius JN
    J Mol Biol; 1999 Aug; 291(4):941-53. PubMed ID: 10452898
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Product binding to the alpha-carboxyl subsite results in a conformational change at the active site of O-acetylserine sulfhydrylase-A: evidence from fluorescence spectroscopy.
    McClure GD; Cook PF
    Biochemistry; 1994 Feb; 33(7):1674-83. PubMed ID: 8110769
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of an allosteric anion-binding site on O-acetylserine sulfhydrylase: structure of the enzyme with chloride bound.
    Burkhard P; Tai CH; Jansonius JN; Cook PF
    J Mol Biol; 2000 Oct; 303(2):279-86. PubMed ID: 11023792
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Substitution of pyridoxal 5'-phosphate in the O-acetylserine sulfhydrylase from Salmonella typhimurium by cofactor analogs provides a test of the mechanism proposed for formation of the alpha-aminoacrylate intermediate.
    Cook PF; Tai CH; Hwang CC; Woehl EU; Dunn MF; Schnackerz KD
    J Biol Chem; 1996 Oct; 271(42):25842-9. PubMed ID: 8824215
    [TBL] [Abstract][Full Text] [Related]  

  • 19. pH dependence of the absorbance and 31P NMR spectra of O-acetylserine sulfhydrylase in the absence and presence of O-acetyl-L-serine.
    Cook PF; Hara S; Nalabolu S; Schnackerz KD
    Biochemistry; 1992 Mar; 31(8):2298-303. PubMed ID: 1540585
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Reaction of alanine racemase with 1-aminoethylphosphonic acid forms a stable external aldimine.
    Stamper GF; Morollo AA; Ringe D
    Biochemistry; 1998 Jul; 37(29):10438-45. PubMed ID: 9671513
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 26.