437 related articles for article (PubMed ID: 8873685)
1. Determination of cytochrome P450 3A4/5 activity in vivo with dextromethorphan N-demethylation.
Jones DR; Gorski JC; Haehner BD; O'Mara EM; Hall SD
Clin Pharmacol Ther; 1996 Oct; 60(4):374-84. PubMed ID: 8873685
[TBL] [Abstract][Full Text] [Related]
2. CYP2D6- and CYP3A-dependent metabolism of dextromethorphan in humans.
Jacqz-Aigrain E; Funck-Brentano C; Cresteil T
Pharmacogenetics; 1993 Aug; 3(4):197-204. PubMed ID: 8220439
[TBL] [Abstract][Full Text] [Related]
3. Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities?
Yu A; Haining RL
Drug Metab Dispos; 2001 Nov; 29(11):1514-20. PubMed ID: 11602530
[TBL] [Abstract][Full Text] [Related]
4. Assessment of CYP2D6 and CYP2C19 activity in vivo in humans: a cocktail study with dextromethorphan and chloroguanide alone and in combination.
Tennezé L; Verstuyft C; Becquemont L; Poirier JM; Wilkinson GR; Funck-Brentano C
Clin Pharmacol Ther; 1999 Dec; 66(6):582-8. PubMed ID: 10613613
[TBL] [Abstract][Full Text] [Related]
5. Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1.
Schmider J; Greenblatt DJ; Fogelman SM; von Moltke LL; Shader RI
Biopharm Drug Dispos; 1997 Apr; 18(3):227-40. PubMed ID: 9113345
[TBL] [Abstract][Full Text] [Related]
6. Characterization of dextromethorphan N-demethylation by human liver microsomes. Contribution of the cytochrome P450 3A (CYP3A) subfamily.
Gorski JC; Jones DR; Wrighton SA; Hall SD
Biochem Pharmacol; 1994 Jul; 48(1):173-82. PubMed ID: 8043020
[TBL] [Abstract][Full Text] [Related]
7. Lack of gender differences and large intrasubject variability in cytochrome P450 activity measured by phenotyping with dextromethorphan.
McCune JS; Lindley C; Decker JL; Williamson KM; Meadowcroft AM; Graff D; Sawyer WT; Blough DK; Pieper JA
J Clin Pharmacol; 2001 Jul; 41(7):723-31. PubMed ID: 11452704
[TBL] [Abstract][Full Text] [Related]
8. A urine metabolic ratio of dextromethorphan and 3-methoxymorphinan as a probe for CYP3A activity and prediction of cyclosporine clearance in healthy volunteers.
Min DI; Ku YM; Vichiendilokkul A; Fleckenstein LL
Pharmacotherapy; 1999 Jun; 19(6):753-9. PubMed ID: 10391422
[TBL] [Abstract][Full Text] [Related]
9. Single-point plasma or urine dextromethorphan method for determining CYP3A activity.
Kuo BP; Hu OY; Hsiong CH; Pao LH; Chen TS; Hung CF
Biopharm Drug Dispos; 2003 Dec; 24(9):367-73. PubMed ID: 14689465
[TBL] [Abstract][Full Text] [Related]
10. Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: role of CYP2C9, CYP2C19, CYP2D6, and CYP3A.
von Moltke LL; Greenblatt DJ; Grassi JM; Granda BW; Venkatakrishnan K; Schmider J; Harmatz JS; Shader RI
J Pharm Pharmacol; 1998 Sep; 50(9):997-1004. PubMed ID: 9811160
[TBL] [Abstract][Full Text] [Related]
11. Assessment of individual CYP2D6 activity in extensive metabolizers with renal failure: comparison of sparteine and dextromethorphan.
Kévorkian JP; Michel C; Hofmann U; Jacqz-Aigrain E; Kroemer HK; Peraldi MN; Eichelbaum M; Jaillon P; Funck-Brentano C
Clin Pharmacol Ther; 1996 May; 59(5):583-92. PubMed ID: 8646830
[TBL] [Abstract][Full Text] [Related]
12. Sex differences in 3,4-methylenedioxymethamphetamine (MDMA; ecstasy)-induced cytochrome P450 2D6 inhibition in humans.
Yubero-Lahoz S; Pardo R; Farré M; O'Mahony B; Torrens M; Mustata C; Pérez-Mañá C; Carbó ML; de la Torre R
Clin Pharmacokinet; 2011 May; 50(5):319-29. PubMed ID: 21456632
[TBL] [Abstract][Full Text] [Related]
13. Enzymes in addition to CYP3A4 and 3A5 mediate N-demethylation of dextromethorphan in human liver microsomes.
Wang Y; Unadkat JD
Biopharm Drug Dispos; 1999 Oct; 20(7):341-6. PubMed ID: 10760842
[TBL] [Abstract][Full Text] [Related]
14. Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".
Streetman DS; Bleakley JF; Kim JS; Nafziger AN; Leeder JS; Gaedigk A; Gotschall R; Kearns GL; Bertino JS
Clin Pharmacol Ther; 2000 Oct; 68(4):375-83. PubMed ID: 11061577
[TBL] [Abstract][Full Text] [Related]
15. The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes.
Kerry NL; Somogyi AA; Bochner F; Mikus G
Br J Clin Pharmacol; 1994 Sep; 38(3):243-8. PubMed ID: 7826826
[TBL] [Abstract][Full Text] [Related]
16. Dextromethorphan as an in vivo probe for the simultaneous determination of CYP2D6 and CYP3A activity.
Ducharme J; Abdullah S; Wainer IW
J Chromatogr B Biomed Appl; 1996 Mar; 678(1):113-28. PubMed ID: 8861661
[TBL] [Abstract][Full Text] [Related]
17. A validated SIM GC/MS method for the simultaneous determination of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in biological matrices and its application to in vitro CYP2D6 and CYP3A4 inhibition study.
Spanakis M; Vizirianakis IS; Mironidou-Tzouveleki M; Niopas I
Biomed Chromatogr; 2009 Nov; 23(11):1131-7. PubMed ID: 19444798
[TBL] [Abstract][Full Text] [Related]
18. In vivo comparison of putative probes of CYP3A4/5 activity: erythromycin, dextromethorphan, and verapamil.
Krecic-Shepard ME; Barnas CR; Slimko J; Gorski JC; Wainer IW; Schwartz JB
Clin Pharmacol Ther; 1999 Jul; 66(1):40-50. PubMed ID: 10430108
[TBL] [Abstract][Full Text] [Related]
19. A sensitive LC-MS/MS assay for the determination of dextromethorphan and metabolites in human urine--application for drug interaction studies assessing potential CYP3A and CYP2D6 inhibition.
Vengurlekar SS; Heitkamp J; McCush F; Velagaleti PR; Brisson JH; Bramer SL
J Pharm Biomed Anal; 2002 Aug; 30(1):113-24. PubMed ID: 12151071
[TBL] [Abstract][Full Text] [Related]
20. Cytochrome P450-dependent metabolism of dextromethorphan: fetal and adult studies.
Jacqz-Aigrain E; Cresteil T
Dev Pharmacol Ther; 1992; 18(3-4):161-8. PubMed ID: 1306804
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
