These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

452 related articles for article (PubMed ID: 8885846)

  • 1. Disposition and biological activity of benzo[a]pyrene-7,8-dione. A genotoxic metabolite generated by dihydrodiol dehydrogenase.
    Flowers L; Bleczinski WF; Burczynski ME; Harvey RG; Penning TM
    Biochemistry; 1996 Oct; 35(42):13664-72. PubMed ID: 8885846
    [TBL] [Abstract][Full Text] [Related]  

  • 2. DNA strand scission by polycyclic aromatic hydrocarbon o-quinones: role of reactive oxygen species, Cu(II)/Cu(I) redox cycling, and o-semiquinone anion radicals,
    Flowers L; Ohnishi ST; Penning TM
    Biochemistry; 1997 Jul; 36(28):8640-8. PubMed ID: 9214311
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Reactivity of benzo[a]pyrene-7,8-dione with DNA. Evidence for the formation of deoxyguanosine adducts.
    Shou M; Harvey RG; Penning TM
    Carcinogenesis; 1993 Mar; 14(3):475-82. PubMed ID: 8384091
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification of benzo[a]pyrene-7,8-dione as an authentic metabolite of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in isolated rat hepatocytes.
    Flowers-Geary L; Harvey RG; Penning TM
    Carcinogenesis; 1995 Nov; 16(11):2707-15. PubMed ID: 7586190
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Contribution of dihydrodiol dehydrogenase to the metabolism of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in fortified rat liver subcellular fractions.
    Shou M; Harvey RG; Penning TM
    Carcinogenesis; 1992 Sep; 13(9):1575-82. PubMed ID: 1394842
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cytotoxicity and mutagenicity of polycyclic aromatic hydrocarbon ortho-quinones produced by dihydrodiol dehydrogenase.
    Flowers-Geary L; Bleczinki W; Harvey RG; Penning TM
    Chem Biol Interact; 1996 Jan; 99(1-3):55-72. PubMed ID: 8620579
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione.
    Burczynski ME; Harvey RG; Penning TM
    Biochemistry; 1998 May; 37(19):6781-90. PubMed ID: 9578563
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Lack of contribution of covalent benzo[a]pyrene-7,8-quinone-DNA adducts in benzo[a]pyrene-induced mouse lung tumorigenesis.
    Nesnow S; Nelson G; Padgett WT; George MH; Moore T; King LC; Adams LD; Ross JA
    Chem Biol Interact; 2010 Jul; 186(2):157-65. PubMed ID: 20346927
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Generation of reactive oxygen species during the enzymatic oxidation of polycyclic aromatic hydrocarbon trans-dihydrodiols catalyzed by dihydrodiol dehydrogenase.
    Penning TM; Ohnishi ST; Ohnishi T; Harvey RG
    Chem Res Toxicol; 1996; 9(1):84-92. PubMed ID: 8924621
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons.
    Shimada T; Martin MV; Pruess-Schwartz D; Marnett LJ; Guengerich FP
    Cancer Res; 1989 Nov; 49(22):6304-12. PubMed ID: 2509067
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Relationship between benzo(a)pyrene-induced DNA base modification and frequency of reverse mutations in mutant strains of Salmonella typhimurium.
    Fahl WE; Scarpelli DG; Gill K
    Cancer Res; 1981 Sep; 41(9 Pt 1):3400-6. PubMed ID: 6266655
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Dihydrodiol dehydrogenase and its role in polycyclic aromatic hydrocarbon metabolism.
    Penning TM
    Chem Biol Interact; 1993 Oct; 89(1):1-34. PubMed ID: 8221964
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Stable expression of rat dihydrodiol dehydrogenase (AKR1C9) in human breast MCF-7 cells results in the formation of PAH-o-quinones and enzyme mediated cell death.
    Tsuruda L; Hou Yt ; Penning TM
    Chem Res Toxicol; 2001 Jul; 14(7):856-62. PubMed ID: 11453732
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Reactive oxygen species generated by PAH o-quinones cause change-in-function mutations in p53.
    Yu D; Berlin JA; Penning TM; Field J
    Chem Res Toxicol; 2002 Jun; 15(6):832-42. PubMed ID: 12067251
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase.
    Burczynski ME; Lin HK; Penning TM
    Cancer Res; 1999 Feb; 59(3):607-14. PubMed ID: 9973208
    [TBL] [Abstract][Full Text] [Related]  

  • 16. NAD(P)H:quinone oxidoreductase 1 reduces the mutagenicity of DNA caused by NADPH:P450 reductase-activated metabolites of benzo(a)pyrene quinones.
    Joseph P; Jaiswal AK
    Br J Cancer; 1998 Mar; 77(5):709-19. PubMed ID: 9514048
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Contrasting disposition and metabolism of topically applied benzo(a)pyrene, trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in mouse epidermis in vivo.
    Melikian AA; Bagheri K; Hecht SS
    Cancer Res; 1987 Oct; 47(20):5354-60. PubMed ID: 3115566
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Benzo[a]pyrene-7,8-quinone-3'-mononucleotide adduct standards for 32P postlabeling analyses: detection of benzo[a]pyrene-7,8-quinone-calf thymus DNA adducts.
    Balu N; Padgett WT; Nelson GB; Lambert GR; Ross JA; Nesnow S
    Anal Biochem; 2006 Aug; 355(2):213-23. PubMed ID: 16797471
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibitory effect of 3-hydroxybenzo(a)pyrene on the mutagenicity and tumorigenicity of (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene.
    Huang MT; Wood AW; Chang RL; Yagi H; Sayer JM; Jerina DM; Conney AH
    Cancer Res; 1986 Feb; 46(2):558-66. PubMed ID: 3079665
    [TBL] [Abstract][Full Text] [Related]  

  • 20. In vivo formation and persistence of DNA adducts in mouse and rat skin exposed to (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene and (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.
    Rojas M; Alexandrov K
    Carcinogenesis; 1986 Sep; 7(9):1553-60. PubMed ID: 3091285
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.