BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

267 related articles for article (PubMed ID: 8887654)

  • 1. The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases.
    Dennis PB; Pullen N; Kozma SC; Thomas G
    Mol Cell Biol; 1996 Nov; 16(11):6242-51. PubMed ID: 8887654
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Multiple independent inputs are required for activation of the p70 S6 kinase.
    Weng QP; Andrabi K; Kozlowski MT; Grove JR; Avruch J
    Mol Cell Biol; 1995 May; 15(5):2333-40. PubMed ID: 7739516
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites.
    Han JW; Pearson RB; Dennis PB; Thomas G
    J Biol Chem; 1995 Sep; 270(36):21396-403. PubMed ID: 7545671
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase.
    von Manteuffel SR; Gingras AC; Ming XF; Sonenberg N; Thomas G
    Proc Natl Acad Sci U S A; 1996 Apr; 93(9):4076-80. PubMed ID: 8633019
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Constitutive activation of S6 kinase by deletion of amino-terminal autoinhibitory and rapamycin sensitivity domains.
    Mahalingam M; Templeton DJ
    Mol Cell Biol; 1996 Jan; 16(1):405-13. PubMed ID: 8524322
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylation.
    Dennis PB; Pullen N; Pearson RB; Kozma SC; Thomas G
    J Biol Chem; 1998 Jun; 273(24):14845-52. PubMed ID: 9614086
    [TBL] [Abstract][Full Text] [Related]  

  • 7. An intracellular calcium signal activates p70 but not p90 ribosomal S6 kinase in liver epithelial cells.
    Graves LM; He Y; Lambert J; Hunter D; Li X; Earp HS
    J Biol Chem; 1997 Jan; 272(3):1920-8. PubMed ID: 8999881
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism.
    Hara K; Yonezawa K; Weng QP; Kozlowski MT; Belham C; Avruch J
    J Biol Chem; 1998 Jun; 273(23):14484-94. PubMed ID: 9603962
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf.
    Cross DA; Alessi DR; Vandenheede JR; McDowell HE; Hundal HS; Cohen P
    Biochem J; 1994 Oct; 303 ( Pt 1)(Pt 1):21-6. PubMed ID: 7945242
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mitogenic signalling by delta opioid receptors expressed in rat-1 fibroblasts involves activation of the p70s6k/p85s6k S6 kinase.
    Wilson MA; Burt AR; Milligan G; Anderson NG
    Biochem J; 1997 Jul; 325 ( Pt 1)(Pt 1):217-22. PubMed ID: 9224649
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1.
    Phin S; Kupferwasser D; Lam J; Lee-Fruman KK
    Biochem J; 2003 Jul; 373(Pt 2):583-91. PubMed ID: 12713446
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies.
    Weng QP; Kozlowski M; Belham C; Zhang A; Comb MJ; Avruch J
    J Biol Chem; 1998 Jun; 273(26):16621-9. PubMed ID: 9632736
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.
    Zhang Y; Dong Z; Nomura M; Zhong S; Chen N; Bode AM; Dong Z
    J Biol Chem; 2001 Jun; 276(24):20913-23. PubMed ID: 11279232
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase.
    Kirken RA; Malabarba MG; Xu J; DaSilva L; Erwin RA; Liu X; Hennighausen L; Rui H; Farrar WL
    J Biol Chem; 1997 Jun; 272(24):15459-65. PubMed ID: 9182578
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The immunosuppressant rapamycin induces inactivation of p70s6k through dephosphorylation of a novel set of sites.
    Ferrari S; Pearson RB; Siegmann M; Kozma SC; Thomas G
    J Biol Chem; 1993 Aug; 268(22):16091-4. PubMed ID: 8344891
    [TBL] [Abstract][Full Text] [Related]  

  • 16. ANG II activates effectors of mTOR via PI3-K signaling in human coronary smooth muscle cells.
    Hafizi S; Wang X; Chester AH; Yacoub MH; Proud CG
    Am J Physiol Heart Circ Physiol; 2004 Sep; 287(3):H1232-8. PubMed ID: 15317677
    [TBL] [Abstract][Full Text] [Related]  

  • 17. ATP-dependent choline phosphate-induced mitogenesis in fibroblasts involves activation of pp70 S6 kinase and phosphatidylinositol 3'-kinase through an extracellular site. Synergistic mitogenic effects of choline phosphate and sphingosine 1-phosphate.
    Chung T; Crilly KS; Anderson WH; Mukherjee JJ; Kiss Z
    J Biol Chem; 1997 Jan; 272(5):3064-72. PubMed ID: 9006957
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Signal pathways involved in activation of p70S6K and phosphorylation of 4E-BP1 following exposure of multiple myeloma tumor cells to interleukin-6.
    Shi Y; Hsu JH; Hu L; Gera J; Lichtenstein A
    J Biol Chem; 2002 May; 277(18):15712-20. PubMed ID: 11872747
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Rapamycin dissociates p70(S6K) activation from DNA synthesis stimulated by bombesin and insulin in Swiss 3T3 cells.
    Withers DJ; Seufferlein T; Mann D; Garcia B; Jones N; Rozengurt E
    J Biol Chem; 1997 Jan; 272(4):2509-14. PubMed ID: 8999966
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes.
    Pham PT; Heydrick SJ; Fox HL; Kimball SR; Jefferson LS; Lynch CJ
    J Cell Biochem; 2000 Sep; 79(3):427-41. PubMed ID: 10972980
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.