BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

145 related articles for article (PubMed ID: 8894101)

  • 1. The rationale for E2020 as a potent acetylcholinesterase inhibitor.
    Kawakami Y; Inoue A; Kawai T; Wakita M; Sugimoto H; Hopfinger AJ
    Bioorg Med Chem; 1996 Sep; 4(9):1429-46. PubMed ID: 8894101
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs.
    Kryger G; Silman I; Sussman JL
    Structure; 1999 Mar; 7(3):297-307. PubMed ID: 10368299
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYSDOC program.
    Pang YP; Kozikowski AP
    J Comput Aided Mol Des; 1994 Dec; 8(6):683-93. PubMed ID: 7738604
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Three-dimensional structure of a complex of E2020 with acetylcholinesterase from Torpedo californica.
    Kryger G; Silman I; Sussman JL
    J Physiol Paris; 1998; 92(3-4):191-4. PubMed ID: 9789806
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases.
    Saxena A; Fedorko JM; Vinayaka CR; Medhekar R; Radić Z; Taylor P; Lockridge O; Doctor BP
    Eur J Biochem; 2003 Nov; 270(22):4447-58. PubMed ID: 14622273
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and acetylcholinesterase inhibitory activity of huperzine A-E2020 combined compound.
    Zeng F; Jiang H; Zhai Y; Zhang H; Chen K; Ji R
    Bioorg Med Chem Lett; 1999 Dec; 9(23):3279-84. PubMed ID: 10612585
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Conformational analyses and molecular-shape comparisons of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase.
    Cardozo MG; Kawai T; Iimura Y; Sugimoto H; Yamanishi Y; Hopfinger AJ
    J Med Chem; 1992 Feb; 35(3):590-601. PubMed ID: 1738152
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Dynamic mechanism of E2020 binding to acetylcholinesterase: a steered molecular dynamics simulation.
    Niu C; Xu Y; Xu Y; Luo X; Duan W; Silman I; Sussman JL; Zhu W; Chen K; Shen J; Jiang H
    J Phys Chem B; 2005 Dec; 109(49):23730-8. PubMed ID: 16375354
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-based 3D QSAR and design of novel acetylcholinesterase inhibitors.
    Sippl W; Contreras JM; Parrot I; Rival YM; Wermuth CG
    J Comput Aided Mol Des; 2001 May; 15(5):395-410. PubMed ID: 11394735
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors.
    Sugimoto H; Yamanishi Y; Iimura Y; Kawakami Y
    Curr Med Chem; 2000 Mar; 7(3):303-39. PubMed ID: 10637367
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues.
    Caliandro R; Pesaresi A; Cariati L; Procopio A; Oliverio M; Lamba D
    J Enzyme Inhib Med Chem; 2018 Dec; 33(1):794-803. PubMed ID: 29651884
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The simulated binding of (+/-)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]meth yl] -1H-inden-1-one hydrochloride (E2020) and related inhibitors to free and acylated acetylcholinesterases and corresponding structure-activity analyses.
    Inoue A; Kawai T; Wakita M; Iimura Y; Sugimoto H; Kawakami Y
    J Med Chem; 1996 Oct; 39(22):4460-70. PubMed ID: 8893840
    [TBL] [Abstract][Full Text] [Related]  

  • 13. QSAR analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase.
    Cardozo MG; Iimura Y; Sugimoto H; Yamanishi Y; Hopfinger AJ
    J Med Chem; 1992 Feb; 35(3):584-9. PubMed ID: 1738151
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block.
    Clark JK; Cowley P; Muir AW; Palin R; Pow E; Prosser AB; Taylor R; Zhang MQ
    Bioorg Med Chem Lett; 2002 Sep; 12(18):2565-8. PubMed ID: 12182861
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Targeting Alzheimer's disease by investigating previously unexplored chemical space surrounding the cholinesterase inhibitor donepezil.
    van Greunen DG; Cordier W; Nell M; van der Westhuyzen C; Steenkamp V; Panayides JL; Riley DL
    Eur J Med Chem; 2017 Feb; 127():671-690. PubMed ID: 27823887
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds.
    Sugimoto H; Iimura Y; Yamanishi Y; Yamatsu K
    J Med Chem; 1995 Nov; 38(24):4821-9. PubMed ID: 7490731
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Kinetic study on the inhibition of acetylcholinesterase by 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride (E2020).
    Nochi S; Asakawa N; Sato T
    Biol Pharm Bull; 1995 Aug; 18(8):1145-7. PubMed ID: 8535413
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids.
    Bautista-Aguilera OM; Esteban G; Chioua M; Nikolic K; Agbaba D; Moraleda I; Iriepa I; Soriano E; Samadi A; Unzeta M; Marco-Contelles J
    Drug Des Devel Ther; 2014; 8():1893-910. PubMed ID: 25378907
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies.
    Korabecny J; Dolezal R; Cabelova P; Horova A; Hruba E; Ricny J; Sedlacek L; Nepovimova E; Spilovska K; Andrs M; Musilek K; Opletalova V; Sepsova V; Ripova D; Kuca K
    Eur J Med Chem; 2014 Jul; 82():426-38. PubMed ID: 24929293
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Docking analysis of a series of benzylamino acetylcholinesterase inhibitors with a phthalimide, benzoyl, or indanone moiety.
    Yamamoto Y; Ishihara Y; Kuntz ID
    J Med Chem; 1994 Sep; 37(19):3141-53. PubMed ID: 7932538
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.