These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

166 related articles for article (PubMed ID: 8951224)

  • 21. Addressing the metabolic activation potential of new leads in drug discovery: a case study using ion trap mass spectrometry and tritium labeling techniques.
    Samuel K; Yin W; Stearns RA; Tang YS; Chaudhary AG; Jewell JP; Lanza T; Lin LS; Hagmann WK; Evans DC; Kumar S
    J Mass Spectrom; 2003 Feb; 38(2):211-21. PubMed ID: 12577288
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Glutathione transferase zeta-catalyzed bioactivation of dichloroacetic acid: reaction of glyoxylate with amino acid nucleophiles.
    Anderson WB; Board PG; Anders MW
    Chem Res Toxicol; 2004 May; 17(5):650-62. PubMed ID: 15144222
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.
    Chen Q; Doss GA; Tung EC; Liu W; Tang YS; Braun MP; Didolkar V; Strauss JR; Wang RW; Stearns RA; Evans DC; Baillie TA; Tang W
    Drug Metab Dispos; 2006 Jan; 34(1):145-51. PubMed ID: 16251255
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s.
    Wen B; Ma L; Zhu M
    Chem Biol Interact; 2008 May; 173(1):59-67. PubMed ID: 18359012
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Approach for in vivo protein binding of 5-n-butyl-pyrazolo[1,5-a]pyrimidine bioactivated in chimeric mice with humanized liver by two-dimensional electrophoresis with accelerator mass spectrometry.
    Yamazaki H; Kuribayashi S; Inoue T; Tateno C; Nishikura Y; Oofusa K; Harada D; Naito S; Horie T; Ohta S
    Chem Res Toxicol; 2010 Jan; 23(1):152-8. PubMed ID: 19928966
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Bioactivation of phenytoin by human cytochrome P450: characterization of the mechanism and targets of covalent adduct formation.
    Munns AJ; De Voss JJ; Hooper WD; Dickinson RG; Gillam EM
    Chem Res Toxicol; 1997 Sep; 10(9):1049-58. PubMed ID: 9305589
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Metabolic activation of the phenothiazine antipsychotics chlorpromazine and thioridazine to electrophilic iminoquinone species in human liver microsomes and recombinant P450s.
    Wen B; Zhou M
    Chem Biol Interact; 2009 Oct; 181(2):220-6. PubMed ID: 19482014
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid.
    Wang YP; Yan J; Fu PP; Chou MW
    Toxicol Lett; 2005 Mar; 155(3):411-20. PubMed ID: 15649625
    [TBL] [Abstract][Full Text] [Related]  

  • 29. In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans.
    Lang D; Freudenberger C; Weinz C
    Drug Metab Dispos; 2009 May; 37(5):1046-55. PubMed ID: 19196846
    [TBL] [Abstract][Full Text] [Related]  

  • 30. In vitro biotransformation of 3,4-dihydro-6-hydroxy-2,2-dimethyl-7-methoxy-1(2H)-benzopyran (CR-6), a potent lipid peroxidation inhibitor and nitric oxide scavenger, in rat liver microsomes.
    Yenes S; Commandeur JN; Vermeulen NP; Messeguer A
    Chem Res Toxicol; 2004 Jul; 17(7):904-13. PubMed ID: 15257615
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Bioactivation of 4-methylphenol (p-cresol) via cytochrome P450-mediated aromatic oxidation in human liver microsomes.
    Yan Z; Zhong HM; Maher N; Torres R; Leo GC; Caldwell GW; Huebert N
    Drug Metab Dispos; 2005 Dec; 33(12):1867-76. PubMed ID: 16174805
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Bioactivation of 4-ipomeanol by CYP4B1: adduct characterization and evidence for an enedial intermediate.
    Baer BR; Rettie AE; Henne KR
    Chem Res Toxicol; 2005 May; 18(5):855-64. PubMed ID: 15892579
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
    Tang W; Stearns RA; Bandiera SM; Zhang Y; Raab C; Braun MP; Dean DC; Pang J; Leung KH; Doss GA; Strauss JR; Kwei GY; Rushmore TH; Chiu SH; Baillie TA
    Drug Metab Dispos; 1999 Mar; 27(3):365-72. PubMed ID: 10064567
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Elucidation of a novel bioactivation pathway of a 3,4-unsubstituted isoxazole in human liver microsomes: formation of a glutathione adduct of a cyanoacrolein derivative after isoxazole ring opening.
    Yu J; Folmer JJ; Hoesch V; Doherty J; Campbell JB; Burdette D
    Drug Metab Dispos; 2011 Feb; 39(2):302-11. PubMed ID: 21045198
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Metabolism of 1-chloro-2-methylpropene. Evidence for reactive chloroaldehyde intermediates.
    Srinivas P; Burka LT
    Drug Metab Dispos; 1988; 16(3):449-54. PubMed ID: 2900739
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes.
    Yao HT; Wu YS; Chang YW; Hsieh HP; Chen WC; Lan SJ; Chen CT; Chao YS; Chang L; Sun HY; Yeh TK
    Drug Metab Dispos; 2007 Jul; 35(7):1042-9. PubMed ID: 17403915
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
    Kalgutkar AS; Hatch HL; Kosea F; Nguyen HT; Choo EF; McClure KF; Taylor TJ; Henne KR; Kuperman AV; Dombroski MA; Letavic MA
    Biopharm Drug Dispos; 2006 Nov; 27(8):371-86. PubMed ID: 16944451
    [TBL] [Abstract][Full Text] [Related]  

  • 38. In vitro metabolism of a new anticancer agent, 6-N-formylamino-12, 13-dihydro-1,11-dihydroxy-13-(beta-D-glucopyranosil)5H-indolo+ ++[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (NB-506), in mice, rats, dogs, and humans.
    Takenaga N; Hasegawa T; Ishii M; Ishizaki H; Hata S; Kamei T
    Drug Metab Dispos; 1999 Feb; 27(2):213-20. PubMed ID: 9929505
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Metabolic activation of fluoropyrrolidine dipeptidyl peptidase-IV inhibitors by rat liver microsomes.
    Xu S; Zhu B; Teffera Y; Pan DE; Caldwell CG; Doss G; Stearns RA; Evans DC; Beconi MG
    Drug Metab Dispos; 2005 Jan; 33(1):121-30. PubMed ID: 15486074
    [TBL] [Abstract][Full Text] [Related]  

  • 40. A novel bioactivation pathway for 2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid (diclofenac) initiated by cytochrome P450-mediated oxidative decarboxylation.
    Grillo MP; Ma J; Teffera Y; Waldon DJ
    Drug Metab Dispos; 2008 Sep; 36(9):1740-4. PubMed ID: 18541695
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 9.