178 related articles for article (PubMed ID: 8968059)
1. Metabolic activation of the potent carcinogen dibenzo[a,l]pyrene by human recombinant cytochromes P450, lung and liver microsomes.
Shou M; Krausz KW; Gonzalez FJ; Gelboin HV
Carcinogenesis; 1996 Nov; 17(11):2429-33. PubMed ID: 8968059
[TBL] [Abstract][Full Text] [Related]
2. Metabolic activation of racemic and enantiomeric trans-8, 9-dihydroxy-8,9-dihydrodibenzo[a,l]pyrene (dibenzo[def,p]chrysene) to dibenzo[a,l]pyrene-bis-dihydrodiols by induced rat liver microsomes and a recombinant human P450 1A1 system: the role of the K-region-derived metabolic intermediates in the formation of dibenzo[a,l]pyrene-DNA adducts.
Nesnow S; Davis C; Padgett W; George M; Lambert G; Meyers F; Allison J; Adams L; King LC
Chem Res Toxicol; 1998 Dec; 11(12):1596-607. PubMed ID: 9860506
[TBL] [Abstract][Full Text] [Related]
3. A quantitative comparison of dibenzo[a,l]pyrene-DNA adduct formation by recombinant human cytochrome P450 microsomes.
King LC; Adams L; Allison J; Kohan MJ; Nelson G; Desai D; Amin S; Ross JA
Mol Carcinog; 1999 Oct; 26(2):74-82. PubMed ID: 10506751
[TBL] [Abstract][Full Text] [Related]
4. Metabolic activation of the potent carcinogen dibenzo[a,h]anthracene by cDNA-expressed human cytochromes P450.
Shou M; Krausz KW; Gonzalez FJ; Gelboin HV
Arch Biochem Biophys; 1996 Apr; 328(1):201-7. PubMed ID: 8638931
[TBL] [Abstract][Full Text] [Related]
5. Metabolism of 5-methylchrysene and 6-methylchrysene by human hepatic and pulmonary cytochrome P450 enzymes.
Koehl W; Amin S; Staretz ME; Ueng YF; Yamazaki H; Tateishi T; Guengerich FP; Hecht SS
Cancer Res; 1996 Jan; 56(2):316-24. PubMed ID: 8542586
[TBL] [Abstract][Full Text] [Related]
6. Specificity of cDNA-expressed human and rodent cytochrome P450s in the oxidative metabolism of the potent carcinogen 7,12-dimethylbenz[a]anthracene.
Shou M; Korzekwa KR; Krausz KW; Buters JT; Grogan J; Goldfarb I; Hardwick JP; Gonzalez FJ; Gelboin HV
Mol Carcinog; 1996 Dec; 17(4):241-9. PubMed ID: 8989918
[TBL] [Abstract][Full Text] [Related]
7. The K-region trans-8,9-diol does not significantly contribute as an intermediate in the metabolic activation of dibenzo[a,l]pyrene to DNA-binding metabolites by human cytochrome P450 1A1 or 1B1.
Luch A; Kishiyama S; Seidel A; Doehmer J; Greim H; Baird WM
Cancer Res; 1999 Sep; 59(18):4603-9. PubMed ID: 10493514
[TBL] [Abstract][Full Text] [Related]
8. Metabolic activation of dibenzo[a,l]pyrene by human cytochrome P450 1A1 and P450 1B1 expressed in V79 Chinese hamster cells.
Luch A; Schober W; Soballa VJ; Raab G; Greim H; Jacob J; Doehmer J; Seidel A
Chem Res Toxicol; 1999 Apr; 12(4):353-64. PubMed ID: 10207125
[TBL] [Abstract][Full Text] [Related]
9. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells.
Smith TJ; Guo Z; Gonzalez FJ; Guengerich FP; Stoner GD; Yang CS
Cancer Res; 1992 Apr; 52(7):1757-63. PubMed ID: 1312898
[TBL] [Abstract][Full Text] [Related]
10. Comparative metabolism of the aza polynuclear aromatic hydrocarbon dibenz[a,h]acridine by recombinant human and rat cytochrome P450s.
Yuan ZX; Kumar S; Sikka HC
Chem Res Toxicol; 2004 May; 17(5):672-8. PubMed ID: 15144224
[TBL] [Abstract][Full Text] [Related]
11. The role of 12 cDNA-expressed human, rodent, and rabbit cytochromes P450 in the metabolism of benzo[a]pyrene and benzo[a]pyrene trans-7,8-dihydrodiol.
Shou M; Korzekwa KR; Crespi CL; Gonzalez FJ; Gelboin HV
Mol Carcinog; 1994 Jul; 10(3):159-68. PubMed ID: 8043197
[TBL] [Abstract][Full Text] [Related]
12. Synthesis of fjord region tetraols and their use in hepatic biotransformation studies of dihydrodiols of benzo[c]chrysene, benzo[g]chrysene and dibenzo[a,l]pyrene.
Luch A; Platt KL; Seidel A
Carcinogenesis; 1998 Apr; 19(4):639-48. PubMed ID: 9600349
[TBL] [Abstract][Full Text] [Related]
13. Stable expression of human cytochrome P450 1B1 in V79 Chinese hamster cells and metabolically catalyzed DNA adduct formation of dibenzo[a,l]pyrene.
Luch A; Coffing SL; Tang YM; Schneider A; Soballa V; Greim H; Jefcoate CR; Seidel A; Greenlee WF; Baird WM; Doehmer J
Chem Res Toxicol; 1998 Jun; 11(6):686-95. PubMed ID: 9625737
[TBL] [Abstract][Full Text] [Related]
14. Kinetic analysis of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes and the effect of P450-specific chemical inhibitors on this activation in human liver microsomes.
Patten CJ; Smith TJ; Murphy SE; Wang MH; Lee J; Tynes RE; Koch P; Yang CS
Arch Biochem Biophys; 1996 Sep; 333(1):127-38. PubMed ID: 8806763
[TBL] [Abstract][Full Text] [Related]
15. Roles of human hepatic and pulmonary cytochrome P450 enzymes in the metabolism of the environmental carcinogen 6-nitrochrysene.
Chae YH; Yun CH; Guengerich FP; Kadlubar FF; el-Bayoumy K
Cancer Res; 1993 May; 53(9):2028-34. PubMed ID: 8481905
[TBL] [Abstract][Full Text] [Related]
16. Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009.
Shimada T; Oda Y; Gillam EM; Guengerich FP; Inoue K
Drug Metab Dispos; 2001 Sep; 29(9):1176-82. PubMed ID: 11502724
[TBL] [Abstract][Full Text] [Related]
17. Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome p450 reductase.
Arlt VM; Stiborova M; Hewer A; Schmeiser HH; Phillips DH
Cancer Res; 2003 Jun; 63(11):2752-61. PubMed ID: 12782579
[TBL] [Abstract][Full Text] [Related]
18. Oxidation of 1,2-epoxy-3-butene to 1,2:3,4-diepoxybutane by cDNA-expressed human cytochromes P450 2E1 and 3A4 and human, mouse and rat liver microsomes.
Seaton MJ; Follansbee MH; Bond JA
Carcinogenesis; 1995 Oct; 16(10):2287-93. PubMed ID: 7586124
[TBL] [Abstract][Full Text] [Related]
19. Cytochrome P450 1B1 determines susceptibility to dibenzo[a,l]pyrene-induced tumor formation.
Buters JT; Mahadevan B; Quintanilla-Martinez L; Gonzalez FJ; Greim H; Baird WM; Luch A
Chem Res Toxicol; 2002 Sep; 15(9):1127-35. PubMed ID: 12230405
[TBL] [Abstract][Full Text] [Related]
20. Contribution of human cytochrome P450 to benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol metabolism, as predicted from heterologous expression in yeast.
Gautier JC; Lecoeur S; Cosme J; Perret A; Urban P; Beaune P; Pompon D
Pharmacogenetics; 1996 Dec; 6(6):489-99. PubMed ID: 9014198
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]