344 related articles for article (PubMed ID: 8972214)
1. A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.
Klippel A; Kavanaugh WM; Pot D; Williams LT
Mol Cell Biol; 1997 Jan; 17(1):338-44. PubMed ID: 8972214
[TBL] [Abstract][Full Text] [Related]
2. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate.
Franke TF; Kaplan DR; Cantley LC; Toker A
Science; 1997 Jan; 275(5300):665-8. PubMed ID: 9005852
[TBL] [Abstract][Full Text] [Related]
3. High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity.
Frech M; Andjelkovic M; Ingley E; Reddy KK; Falck JR; Hemmings BA
J Biol Chem; 1997 Mar; 272(13):8474-81. PubMed ID: 9079675
[TBL] [Abstract][Full Text] [Related]
4. Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation.
King WG; Mattaliano MD; Chan TO; Tsichlis PN; Brugge JS
Mol Cell Biol; 1997 Aug; 17(8):4406-18. PubMed ID: 9234699
[TBL] [Abstract][Full Text] [Related]
5. Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors.
Freeburn RW; Wright KL; Burgess SJ; Astoul E; Cantrell DA; Ward SG
J Immunol; 2002 Nov; 169(10):5441-50. PubMed ID: 12421919
[TBL] [Abstract][Full Text] [Related]
6. SIP/SHIP inhibits Xenopus oocyte maturation induced by insulin and phosphatidylinositol 3-kinase.
Deuter-Reinhard M; Apell G; Pot D; Klippel A; Williams LT; Kavanaugh WM
Mol Cell Biol; 1997 May; 17(5):2559-65. PubMed ID: 9111325
[TBL] [Abstract][Full Text] [Related]
7. Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation.
Kohn AD; Takeuchi F; Roth RA
J Biol Chem; 1996 Sep; 271(36):21920-6. PubMed ID: 8702995
[TBL] [Abstract][Full Text] [Related]
8. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.
Haas-Kogan D; Shalev N; Wong M; Mills G; Yount G; Stokoe D
Curr Biol; 1998 Oct; 8(21):1195-8. PubMed ID: 9799739
[TBL] [Abstract][Full Text] [Related]
9. Constitutive activation of protein kinase B and phosphorylation of p47phox by a membrane-targeted phosphoinositide 3-kinase.
Didichenko SA; Tilton B; Hemmings BA; Ballmer-Hofer K; Thelen M
Curr Biol; 1996 Oct; 6(10):1271-8. PubMed ID: 8939574
[TBL] [Abstract][Full Text] [Related]
10. Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism.
An H; Xu H; Zhang M; Zhou J; Feng T; Qian C; Qi R; Cao X
Blood; 2005 Jun; 105(12):4685-92. PubMed ID: 15701712
[TBL] [Abstract][Full Text] [Related]
11. The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation.
Carricaburu V; Lamia KA; Lo E; Favereaux L; Payrastre B; Cantley LC; Rameh LE
Proc Natl Acad Sci U S A; 2003 Aug; 100(17):9867-72. PubMed ID: 12897244
[TBL] [Abstract][Full Text] [Related]
12. Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB.
Maag D; Maxwell MJ; Hardesty DA; Boucher KL; Choudhari N; Hanno AG; Ma JF; Snowman AS; Pietropaoli JW; Xu R; Storm PB; Saiardi A; Snyder SH; Resnick AC
Proc Natl Acad Sci U S A; 2011 Jan; 108(4):1391-6. PubMed ID: 21220345
[TBL] [Abstract][Full Text] [Related]
13. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase.
Franke TF; Yang SI; Chan TO; Datta K; Kazlauskas A; Morrison DK; Kaplan DR; Tsichlis PN
Cell; 1995 Jun; 81(5):727-36. PubMed ID: 7774014
[TBL] [Abstract][Full Text] [Related]
14. Dual role of SRC homology domain 2-containing inositol phosphatase 2 in the regulation of platelet-derived growth factor and insulin-like growth factor I signaling in rat vascular smooth muscle cells.
Sasaoka T; Kikuchi K; Wada T; Sato A; Hori H; Murakami S; Fukui K; Ishihara H; Aota R; Kimura I; Kobayashi M
Endocrinology; 2003 Sep; 144(9):4204-14. PubMed ID: 12933696
[TBL] [Abstract][Full Text] [Related]
15. Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase.
Kohn AD; Kovacina KS; Roth RA
EMBO J; 1995 Sep; 14(17):4288-95. PubMed ID: 7556070
[TBL] [Abstract][Full Text] [Related]
16. Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells.
Datta K; Bellacosa A; Chan TO; Tsichlis PN
J Biol Chem; 1996 Nov; 271(48):30835-9. PubMed ID: 8940066
[TBL] [Abstract][Full Text] [Related]
17. Phosphatidylinositol (3,4) bisphosphate-specific phosphatases and effector proteins: A distinct branch of PI3K signaling.
Li H; Marshall AJ
Cell Signal; 2015 Sep; 27(9):1789-98. PubMed ID: 26022180
[TBL] [Abstract][Full Text] [Related]
18. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways.
Klippel A; Reinhard C; Kavanaugh WM; Apell G; Escobedo MA; Williams LT
Mol Cell Biol; 1996 Aug; 16(8):4117-27. PubMed ID: 8754810
[TBL] [Abstract][Full Text] [Related]
19. The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane.
Ivetac I; Munday AD; Kisseleva MV; Zhang XM; Luff S; Tiganis T; Whisstock JC; Rowe T; Majerus PW; Mitchell CA
Mol Biol Cell; 2005 May; 16(5):2218-33. PubMed ID: 15716355
[TBL] [Abstract][Full Text] [Related]
20. 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.
Alessi DR; Deak M; Casamayor A; Caudwell FB; Morrice N; Norman DG; Gaffney P; Reese CB; MacDougall CN; Harbison D; Ashworth A; Bownes M
Curr Biol; 1997 Oct; 7(10):776-89. PubMed ID: 9368760
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
