214 related articles for article (PubMed ID: 8981925)
1. Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells.
Redmon JB; Olson LK; Armstrong MB; Greene MJ; Robertson RP
J Clin Invest; 1996 Dec; 98(12):2786-93. PubMed ID: 8981925
[TBL] [Abstract][Full Text] [Related]
2. Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15.
Moran A; Zhang HJ; Olson LK; Harmon JS; Poitout V; Robertson RP
J Clin Invest; 1997 Feb; 99(3):534-9. PubMed ID: 9022089
[TBL] [Abstract][Full Text] [Related]
3. Control of insulin gene expression by glucose.
Goodison S; Kenna S; Ashcroft SJ
Biochem J; 1992 Jul; 285 ( Pt 2)(Pt 2):563-8. PubMed ID: 1322137
[TBL] [Abstract][Full Text] [Related]
4. Tacrolimus causes a blockage of protein secretion which reinforces its immunosuppressive activity and also explains some of its toxic side-effects.
Rauch MC; San Martín A; Ojeda D; Quezada C; Salas M; Cárcamo JG; Yañez AJ; Slebe JC; Claude A
Transpl Immunol; 2009 Dec; 22(1-2):72-81. PubMed ID: 19628039
[TBL] [Abstract][Full Text] [Related]
5. Inhibitory effects of immunosuppressive drugs on insulin secretion from HIT-T15 cells and Wistar rat islets.
Paty BW; Harmon JS; Marsh CL; Robertson RP
Transplantation; 2002 Feb; 73(3):353-7. PubMed ID: 11884930
[TBL] [Abstract][Full Text] [Related]
6. Regulation of insulin gene transcription by a Ca(2+)-responsive pathway involving calcineurin and nuclear factor of activated T cells.
Lawrence MC; Bhatt HS; Watterson JM; Easom RA
Mol Endocrinol; 2001 Oct; 15(10):1758-67. PubMed ID: 11579208
[TBL] [Abstract][Full Text] [Related]
7. Regulation of human insulin gene transcription by glucose, epinephrine, and somatostatin.
Redmon JB; Towle HC; Robertson RP
Diabetes; 1994 Apr; 43(4):546-51. PubMed ID: 7907998
[TBL] [Abstract][Full Text] [Related]
8. Inhibition of insulin production by FK 506 is caused at the transcriptional level in pancreatic beta cell when FK BP-12 content is relatively high.
Tamura K; Fujimura T; Tsutsumi T; Nakamura K; Ogawa T; Atumaru C; Hirano Y; Ohara K; Ohtsuka K; Shimomura K
Transplant Proc; 1995 Feb; 27(1):357-61. PubMed ID: 7533409
[No Abstract] [Full Text] [Related]
9. Differential transcriptional regulation of endothelin-1 by immunosuppressants FK506 and cyclosporin A.
Marsen TA; Weber F; Egink G; Suckau G; Baldamus CA
Fundam Clin Pharmacol; 2000; 14(4):401-8. PubMed ID: 11030448
[TBL] [Abstract][Full Text] [Related]
10. Cyclosporin and tacrolimus impair insulin secretion and transcriptional regulation in INS-1E beta-cells.
Øzbay LA; Smidt K; Mortensen DM; Carstens J; Jørgensen KA; Rungby J
Br J Pharmacol; 2011 Jan; 162(1):136-46. PubMed ID: 20825407
[TBL] [Abstract][Full Text] [Related]
11. Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein.
Olson LK; Redmon JB; Towle HC; Robertson RP
J Clin Invest; 1993 Jul; 92(1):514-9. PubMed ID: 8326016
[TBL] [Abstract][Full Text] [Related]
12. Calcium/calmodulin kinase inhibitors and immunosuppressant macrolides rapamycin and FK506 inhibit progestin- and glucocorticosteroid receptor-mediated transcription in human breast cancer T47D cells.
Le Bihan S; Marsaud V; Mercier-Bodard C; Baulieu EE; Mader S; White JH; Renoir JM
Mol Endocrinol; 1998 Jul; 12(7):986-1001. PubMed ID: 9658403
[TBL] [Abstract][Full Text] [Related]
13. Ca2+/calmodulin-dependent and -independent down-regulation of c-myb mRNA levels in erythropoietin-responsive murine erythroleukemia cells. The role of calcineurin.
Schaefer A; Magócsi M; Stöcker U; Fandrich A; Marquardt H
J Biol Chem; 1996 Jun; 271(23):13484-90. PubMed ID: 8662717
[TBL] [Abstract][Full Text] [Related]
14. The complex of FK506-binding protein 12 and FK506 inhibits calcineurin phosphatase activity and IgE activation-induced cytokine transcripts, but not exocytosis, in mouse mast cells.
Fruman DA; Bierer BE; Benes JE; Burakoff SJ; Austen KF; Katz HR
J Immunol; 1995 Feb; 154(4):1846-51. PubMed ID: 7530743
[TBL] [Abstract][Full Text] [Related]
15. FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin.
O'Keefe SJ; Tamura J; Kincaid RL; Tocci MJ; O'Neill EA
Nature; 1992 Jun; 357(6380):692-4. PubMed ID: 1377361
[TBL] [Abstract][Full Text] [Related]
16. Secretory defects induced by immunosuppressive agents on human pancreatic beta-cells.
Polastri L; Galbiati F; Bertuzzi F; Fiorina P; Nano R; Gregori S; Aldrighetti L; Pozza G; Secchi A; Adorini L; Davalli AM
Acta Diabetol; 2002 Dec; 39(4):229-33. PubMed ID: 12486498
[TBL] [Abstract][Full Text] [Related]
17. Transcriptional inhibition of insulin by FK506 and possible involvement of FK506 binding protein-12 in pancreatic beta-cell.
Tamura K; Fujimura T; Tsutsumi T; Nakamura K; Ogawa T; Atumaru C; Hirano Y; Ohara K; Ohtsuka K; Shimomura K
Transplantation; 1995 Jun; 59(11):1606-13. PubMed ID: 7539960
[TBL] [Abstract][Full Text] [Related]
18. Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets.
Johnson JD; Ao Z; Ao P; Li H; Dai LJ; He Z; Tee M; Potter KJ; Klimek AM; Meloche RM; Thompson DM; Verchere CB; Warnock GL
Cell Transplant; 2009; 18(8):833-45. PubMed ID: 19500470
[TBL] [Abstract][Full Text] [Related]
19. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation.
Clipstone NA; Crabtree GR
Nature; 1992 Jun; 357(6380):695-7. PubMed ID: 1377362
[TBL] [Abstract][Full Text] [Related]
20. Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression.
Olson LK; Sharma A; Peshavaria M; Wright CV; Towle HC; Rodertson RP; Stein R
Proc Natl Acad Sci U S A; 1995 Sep; 92(20):9127-31. PubMed ID: 7568086
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]