These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

129 related articles for article (PubMed ID: 8999809)

  • 1. Molecular basis of the catalytic differences among DT-diaphorase of human, rat, and mouse.
    Chen S; Knox R; Wu K; Deng PS; Zhou D; Bianchet MA; Amzel LM
    J Biol Chem; 1997 Jan; 272(3):1437-9. PubMed ID: 8999809
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Demonstration of the activation of prodrug CB 1954 using human DT-diaphorase mutant Q104Y-transfected MDA-MB-231 cells and mouse xenograft model.
    Wu K; Eng E; Knox R; Chen S
    Arch Biochem Biophys; 2001 Jan; 385(1):203-8. PubMed ID: 11361019
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Catalytic properties of NAD(P)H:quinone acceptor oxidoreductase: study involving mouse, rat, human, and mouse-rat chimeric enzymes.
    Chen S; Knox R; Lewis AD; Friedlos F; Workman P; Deng PS; Fung M; Ebenstein D; Wu K; Tsai TM
    Mol Pharmacol; 1995 May; 47(5):934-9. PubMed ID: 7746280
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase.
    Wu K; Knox R; Sun XZ; Joseph P; Jaiswal AK; Zhang D; Deng PS; Chen S
    Arch Biochem Biophys; 1997 Nov; 347(2):221-8. PubMed ID: 9367528
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Molecular characterization of binding of substrates and inhibitors to DT-diaphorase: combined approach involving site-directed mutagenesis, inhibitor-binding analysis, and computer modeling.
    Chen S; Wu K; Zhang D; Sherman M; Knox R; Yang CS
    Mol Pharmacol; 1999 Aug; 56(2):272-8. PubMed ID: 10419545
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: a novel co-substrate-mediated antitumor prodrug therapy.
    Knox RJ; Jenkins TC; Hobbs SM; Chen S; Melton RG; Burke PJ
    Cancer Res; 2000 Aug; 60(15):4179-86. PubMed ID: 10945627
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-function studies of DT-diaphorase (NQO1) and NRH: quinone oxidoreductase (NQO2).
    Chen S; Wu K; Knox R
    Free Radic Biol Med; 2000 Aug; 29(3-4):276-84. PubMed ID: 11035256
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954).
    Skelly JV; Sanderson MR; Suter DA; Baumann U; Read MA; Gregory DS; Bennett M; Hobbs SM; Neidle S
    J Med Chem; 1999 Oct; 42(21):4325-30. PubMed ID: 10543876
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Site-directed mutagenesis of rat liver NAD(P)H: quinone oxidoreductase: roles of lysine 76 and cysteine 179.
    Ma Q; Cui K; Wang RW; Lu AY; Yang CS
    Arch Biochem Biophys; 1992 May; 294(2):434-9. PubMed ID: 1567199
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase.
    Fourie J; Oleschuk CJ; Guziec F; Guziec L; Fiterman DJ; Monterrosa C; Begleiter A
    Cancer Chemother Pharmacol; 2002 Feb; 49(2):101-10. PubMed ID: 11862423
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide).
    Boland MP; Knox RJ; Roberts JJ
    Biochem Pharmacol; 1991 Mar 15-Apr 1; 41(6-7):867-75. PubMed ID: 1901207
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of novel reduced pyridinium derivatives as synthetic co-factors for the enzyme DT diaphorase (NAD(P)H dehydrogenase (quinone), EC 1.6.99.2).
    Friedlos F; Jarman M; Davies LC; Boland MP; Knox RJ
    Biochem Pharmacol; 1992 Jul; 44(1):25-31. PubMed ID: 1385952
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Advances in research on DT-diaphorase--catalytic properties, regulation of activity and significance in the detoxication of foreign compounds.
    Horie S
    Kitasato Arch Exp Med; 1990 Apr; 63(1):11-30. PubMed ID: 2125671
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Expression of rat liver NAD(P)H:quinone-acceptor oxidoreductase in Escherichia coli and mutagenesis in vitro at Arg-177.
    Chen HH; Ma JX; Forrest GL; Deng PS; Martino PA; Lee TD; Chen S
    Biochem J; 1992 Jun; 284 ( Pt 3)(Pt 3):855-60. PubMed ID: 1622401
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9.
    Fitzsimmons SA; Workman P; Grever M; Paull K; Camalier R; Lewis AD
    J Natl Cancer Inst; 1996 Mar; 88(5):259-69. PubMed ID: 8614004
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase.
    Knox RJ; Friedlos F; Sherwood RF; Melton RG; Anlezark GM
    Biochem Pharmacol; 1992 Dec; 44(12):2297-301. PubMed ID: 1472095
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy.
    Stiborová M; Frei E; Sopko B; Wiessler M; Schmeiser HH
    Carcinogenesis; 2002 Apr; 23(4):617-25. PubMed ID: 11960915
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Gene targeting of DT-diaphorase in mouse embryonic stem cells: establishment of null mutant and its mitomycin C-resistance.
    Yoshida T; Tsuda H
    Biochem Biophys Res Commun; 1995 Sep; 214(2):701-8. PubMed ID: 7677784
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Nitrobenzimidazoles as substrates for DT-diaphorase and redox cycling compounds: their enzymatic reactions and cytotoxicity.
    Sarlauskas J; Dickancaite E; Nemeikaite A; Anusevicius Z; Nivinskas H; Segura-Aguilar J; Cenas N
    Arch Biochem Biophys; 1997 Oct; 346(2):219-29. PubMed ID: 9343369
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Phthalimide analogs of CB 1954: synthesis and bioactivation.
    Mehta LK; Hobbs S; Chen S; Knox RJ; Parrick J
    Anticancer Drugs; 1999 Sep; 10(8):777-83. PubMed ID: 10573210
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.