160 related articles for article (PubMed ID: 9010596)
1. The roles of individual amino acids in altering substrate specificity of the P450 2a4/2a5 enzymes.
Negishi M; Uno T; Honkakoski P; Sueyoshi T; Darden TA; Pedersen LP
Biochimie; 1996; 78(8-9):685-94. PubMed ID: 9010596
[TBL] [Abstract][Full Text] [Related]
2. Reciprocal size-effect relationship of the key residues in determining regio- and stereospecificities of DHEA hydroxylase activity in P450 2a5.
Uno T; Mitchell E; Aida K; Lambert MH; Darden TA; Pedersen LG; Negishi M
Biochemistry; 1997 Mar; 36(11):3193-8. PubMed ID: 9115996
[TBL] [Abstract][Full Text] [Related]
3. Altering the regiospecificity of androstenedione hydroxylase activity in P450s 2a-4/5 by a mutation of the residue at position 481.
Iwasaki M; Darden TA; Pedersen LG; Negishi M
Biochemistry; 1995 Apr; 34(15):5054-9. PubMed ID: 7711025
[TBL] [Abstract][Full Text] [Related]
4. Characterization of cytochrome P450 2A4 and 2A5-catalyzed 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism.
Felicia ND; Rekha GK; Murphy SE
Arch Biochem Biophys; 2000 Dec; 384(2):418-24. PubMed ID: 11368333
[TBL] [Abstract][Full Text] [Related]
5. Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.
Iwasaki M; Lindberg RL; Juvonen RO; Negishi M
Biochem J; 1993 Apr; 291 ( Pt 2)(Pt 2):569-73. PubMed ID: 8484736
[TBL] [Abstract][Full Text] [Related]
6. Interaction of aflatoxin B1 with cytochrome P450 2A5 and its mutants: correlation with metabolic activation and toxicity.
Pelkonen P; Lang MA; Negishi M; Wild CP; Juvonen RO
Chem Res Toxicol; 1997 Jan; 10(1):85-90. PubMed ID: 9074807
[TBL] [Abstract][Full Text] [Related]
7. Role of residues 363 and 206 in conversion of cytochrome P450 2B1 from a steroid 16-hydroxylase to a 15 alpha-hydroxylase.
Luo Z; He YA; Halpert JR
Arch Biochem Biophys; 1994 Feb; 309(1):52-7. PubMed ID: 8117113
[TBL] [Abstract][Full Text] [Related]
8. Structural function of residue-209 in coumarin 7-hydroxylase (P450coh). Enzyme-kinetic studies and site-directed mutagenesis.
Juvonen RO; Iwasaki M; Negishi M
J Biol Chem; 1991 Sep; 266(25):16431-5. PubMed ID: 1885576
[TBL] [Abstract][Full Text] [Related]
9. Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis.
He YA; He YQ; Szklarz GD; Halpert JR
Biochemistry; 1997 Jul; 36(29):8831-9. PubMed ID: 9220969
[TBL] [Abstract][Full Text] [Related]
10. Structural flexibility and functional versatility of cytochrome P450 and rapid evolution.
Negishi M; Iwasaki M; Juvonen RO; Sueyoshi T; Darden TA; Pedersen LG
Mutat Res; 1996 Feb; 350(1):43-50. PubMed ID: 8657195
[TBL] [Abstract][Full Text] [Related]
11. Importance of amino acid residue 474 for substrate specificity of canine and human cytochrome p450 3A enzymes.
He YQ; Roussel F; Halpert JR
Arch Biochem Biophys; 2001 May; 389(2):264-70. PubMed ID: 11339816
[TBL] [Abstract][Full Text] [Related]
12. Molecular modelling of the human cytochrome P450 isoform CYP2A6 and investigations of CYP2A substrate selectivity.
Lewis DF; Dickins M; Lake BG; Eddershaw PJ; Tarbit MH; Goldfarb PS
Toxicology; 1999 Mar; 133(1):1-33. PubMed ID: 10413191
[TBL] [Abstract][Full Text] [Related]
13. Structural flexibility and functional versatility of mammalian P450 enzymes.
Negishi M; Uno T; Darden TA; Sueyoshi T; Pedersen LG
FASEB J; 1996 May; 10(7):683-9. PubMed ID: 8635685
[TBL] [Abstract][Full Text] [Related]
14. Alteration of high and low spin equilibrium by a single mutation of amino acid 209 in mouse cytochromes P450.
Iwasaki M; Juvonen R; Lindberg R; Negishi M
J Biol Chem; 1991 Feb; 266(6):3380-2. PubMed ID: 1995602
[TBL] [Abstract][Full Text] [Related]
15. Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.
Negishi M; Iwasaki M; Juvonen RO; Aida K
J Steroid Biochem Mol Biol; 1992 Dec; 43(8):1031-6. PubMed ID: 22217847
[TBL] [Abstract][Full Text] [Related]
16. Identification of residues 99, 220, and 221 of human cytochrome P450 2C19 as key determinants of omeprazole activity.
Ibeanu GC; Ghanayem BI; Linko P; Li L; Pederson LG; Goldstein JA
J Biol Chem; 1996 May; 271(21):12496-501. PubMed ID: 8647857
[TBL] [Abstract][Full Text] [Related]
17. Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions.
Lewis DF; Lake BG
Xenobiotica; 2002 Jul; 32(7):547-61. PubMed ID: 12162851
[TBL] [Abstract][Full Text] [Related]
18. Engineering mouse P450coh to a novel corticosterone 15 alpha-hydroxylase and modeling steroid-binding orientation in the substrate pocket.
Iwasaki M; Darden TA; Pedersen LG; Davis DG; Juvonen RO; Sueyoshi T; Negishi M
J Biol Chem; 1993 Jan; 268(2):759-62. PubMed ID: 8419350
[TBL] [Abstract][Full Text] [Related]
19. Multiple steroid-binding orientations: alteration of regiospecificity of dehydroepiandrosterone 2- and 7-hydroxylase activities of cytochrome P-450 2a-5 by mutation of residue 209.
Iwasaki M; Davis DG; Darden TA; Pedersen LG; Negishi M
Biochem J; 1995 Feb; 306 ( Pt 1)(Pt 1):29-33. PubMed ID: 7864823
[TBL] [Abstract][Full Text] [Related]
20. Key residues controlling binding of diverse ligands to human cytochrome P450 2A enzymes.
DeVore NM; Smith BD; Wang JL; Lushington GH; Scott EE
Drug Metab Dispos; 2009 Jun; 37(6):1319-27. PubMed ID: 19251817
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]