BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

163 related articles for article (PubMed ID: 9020090)

  • 1. Histidine 265 is important for covalent catalysis by vaccinia topoisomerase and is conserved in all eukaryotic type I enzymes.
    Petersen BO; Shuman S
    J Biol Chem; 1997 Feb; 272(7):3891-6. PubMed ID: 9020090
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mutational analysis of 39 residues of vaccinia DNA topoisomerase identifies Lys-220, Arg-223, and Asn-228 as important for covalent catalysis.
    Cheng C; Wang LK; Sekiguchi J; Shuman S
    J Biol Chem; 1997 Mar; 272(13):8263-9. PubMed ID: 9079646
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Catalytic mechanism of DNA topoisomerase IB.
    Krogh BO; Shuman S
    Mol Cell; 2000 Jun; 5(6):1035-41. PubMed ID: 10911997
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mutational analysis of 26 residues of vaccinia DNA topoisomerase identifies Ser-204 as important for DNA binding and cleavage.
    Wang LK; Wittschieben J; Shuman S
    Biochemistry; 1997 Jul; 36(26):7944-50. PubMed ID: 9201940
    [TBL] [Abstract][Full Text] [Related]  

  • 5. DNA strand transfer catalyzed by vaccinia topoisomerase: peroxidolysis and hydroxylaminolysis of the covalent protein-DNA intermediate.
    Krogh BO; Shuman S
    Biochemistry; 2000 May; 39(21):6422-32. PubMed ID: 10828956
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mechanism of DNA transesterification by vaccinia topoisomerase: catalytic contributions of essential residues Arg-130, Gly-132, Tyr-136 and Lys-167.
    Wittschieben J; Shuman S
    Nucleic Acids Res; 1997 Aug; 25(15):3001-8. PubMed ID: 9224599
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Vaccinia DNA topoisomerase I: kinetic evidence for general acid-base catalysis and a conformational step.
    Stivers JT; Shuman S; Mildvan AS
    Biochemistry; 1994 Dec; 33(51):15449-58. PubMed ID: 7803409
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Replacement of the active site tyrosine of vaccinia DNA topoisomerase by glutamate, cysteine or histidine converts the enzyme into a site-specific endonuclease.
    Wittschieben J; Petersen BO; Shuman S
    Nucleic Acids Res; 1998 Jan; 26(2):490-6. PubMed ID: 9421505
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Stereochemical outcome and kinetic effects of Rp- and Sp-phosphorothioate substitutions at the cleavage site of vaccinia type I DNA topoisomerase.
    Stivers JT; Jagadeesh GJ; Nawrot B; Stec WJ; Shuman S
    Biochemistry; 2000 May; 39(18):5561-72. PubMed ID: 10820030
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The role of histidine 632 in catalysis by human topoisomerase I.
    Yang Z; Champoux JJ
    J Biol Chem; 2001 Jan; 276(1):677-85. PubMed ID: 11024057
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mutational analysis of vaccinia DNA topoisomerase defines amino acid residues essential for covalent catalysis.
    Wittschieben J; Shuman S
    J Biol Chem; 1994 Nov; 269(47):29978-83. PubMed ID: 7961997
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Covalent and noncovalent DNA binding by mutants of vaccinia DNA topoisomerase I.
    Morham SG; Shuman S
    J Biol Chem; 1992 Aug; 267(22):15984-92. PubMed ID: 1322412
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Effect of 2'-5' phosphodiesters on DNA transesterification by vaccinia topoisomerase.
    Krogh BO; Claeboe CD; Hecht SM; Shuman S
    J Biol Chem; 2001 Jun; 276(24):20907-12. PubMed ID: 11399773
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Proton relay mechanism of general acid catalysis by DNA topoisomerase IB.
    Krogh BO; Shuman S
    J Biol Chem; 2002 Feb; 277(8):5711-4. PubMed ID: 11756402
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Benzo[c]phenanthrene adducts and nogalamycin inhibit DNA transesterification by vaccinia topoisomerase.
    Yakovleva L; Handy CJ; Sayer JM; Pirrung M; Jerina DM; Shuman S
    J Biol Chem; 2004 May; 279(22):23335-42. PubMed ID: 15044474
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Individual nucleotide bases, not base pairs, are critical for triggering site-specific DNA cleavage by vaccinia topoisomerase.
    Tian L; Sayer JM; Jerina DM; Shuman S
    J Biol Chem; 2004 Sep; 279(38):39718-26. PubMed ID: 15252055
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Vaccinia DNA topoisomerase I: single-turnover and steady-state kinetic analysis of the DNA strand cleavage and ligation reactions.
    Stivers JT; Shuman S; Mildvan AS
    Biochemistry; 1994 Jan; 33(1):327-39. PubMed ID: 8286354
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mutations within a conserved region of vaccinia topoisomerase affect the DNA cleavage-religation equilibrium.
    Petersen BO; Wittschieben J; Shuman S
    J Mol Biol; 1996 Oct; 263(2):181-95. PubMed ID: 8913300
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Chemical mutagenesis of vaccinia DNA topoisomerase lysine 167 provides insights to the catalysis of DNA transesterification.
    Yakovleva L; Shuman S
    Biochemistry; 2013 Feb; 52(5):984-91. PubMed ID: 23317114
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Nonpolar nucleobase analogs illuminate requirements for site-specific DNA cleavage by vaccinia topoisomerase.
    Yakovleva L; Lai J; Kool ET; Shuman S
    J Biol Chem; 2006 Nov; 281(47):35914-21. PubMed ID: 17005552
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.