164 related articles for article (PubMed ID: 9022089)
1. Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15.
Moran A; Zhang HJ; Olson LK; Harmon JS; Poitout V; Robertson RP
J Clin Invest; 1997 Feb; 99(3):534-9. PubMed ID: 9022089
[TBL] [Abstract][Full Text] [Related]
2. Reconstitution of glucotoxic HIT-T15 cells with somatostatin transcription factor-1 partially restores insulin promoter activity.
Harmon JS; Tanaka Y; Olson LK; Robertson RP
Diabetes; 1998 Jun; 47(6):900-4. PubMed ID: 9604866
[TBL] [Abstract][Full Text] [Related]
3. Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator.
Poitout V; Olson LK; Robertson RP
J Clin Invest; 1996 Feb; 97(4):1041-6. PubMed ID: 8613527
[TBL] [Abstract][Full Text] [Related]
4. Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression.
Olson LK; Sharma A; Peshavaria M; Wright CV; Towle HC; Rodertson RP; Stein R
Proc Natl Acad Sci U S A; 1995 Sep; 92(20):9127-31. PubMed ID: 7568086
[TBL] [Abstract][Full Text] [Related]
5. Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants.
Tanaka Y; Gleason CE; Tran PO; Harmon JS; Robertson RP
Proc Natl Acad Sci U S A; 1999 Sep; 96(19):10857-62. PubMed ID: 10485916
[TBL] [Abstract][Full Text] [Related]
6. Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells.
Harmon JS; Stein R; Robertson RP
J Biol Chem; 2005 Mar; 280(12):11107-13. PubMed ID: 15664999
[TBL] [Abstract][Full Text] [Related]
7. The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression.
Sharma A; Olson LK; Robertson RP; Stein R
Mol Endocrinol; 1995 Sep; 9(9):1127-34. PubMed ID: 7491105
[TBL] [Abstract][Full Text] [Related]
8. Determinants of glucose toxicity and its reversibility in the pancreatic islet beta-cell line, HIT-T15.
Gleason CE; Gonzalez M; Harmon JS; Robertson RP
Am J Physiol Endocrinol Metab; 2000 Nov; 279(5):E997-1002. PubMed ID: 11052953
[TBL] [Abstract][Full Text] [Related]
9. Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells.
Matsuoka T; Kajimoto Y; Watada H; Kaneto H; Kishimoto M; Umayahara Y; Fujitani Y; Kamada T; Kawamori R; Yamasaki Y
J Clin Invest; 1997 Jan; 99(1):144-50. PubMed ID: 9011569
[TBL] [Abstract][Full Text] [Related]
10. Glucose rapidly and reversibly decreases INS-1 cell insulin gene transcription via decrements in STF-1 and C1 activator transcription factor activity.
Olson LK; Qian J; Poitout V
Mol Endocrinol; 1998 Feb; 12(2):207-19. PubMed ID: 9482663
[TBL] [Abstract][Full Text] [Related]
11. Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein.
Olson LK; Redmon JB; Towle HC; Robertson RP
J Clin Invest; 1993 Jul; 92(1):514-9. PubMed ID: 8326016
[TBL] [Abstract][Full Text] [Related]
12. Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose.
Marshak S; Leibowitz G; Bertuzzi F; Socci C; Kaiser N; Gross DJ; Cerasi E; Melloul D
Diabetes; 1999 Jun; 48(6):1230-6. PubMed ID: 10342809
[TBL] [Abstract][Full Text] [Related]
13. Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells.
Redmon JB; Olson LK; Armstrong MB; Greene MJ; Robertson RP
J Clin Invest; 1996 Dec; 98(12):2786-93. PubMed ID: 8981925
[TBL] [Abstract][Full Text] [Related]
14. Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations.
Robertson RP; Zhang HJ; Pyzdrowski KL; Walseth TF
J Clin Invest; 1992 Aug; 90(2):320-5. PubMed ID: 1644911
[TBL] [Abstract][Full Text] [Related]
15. Response to glucose of transcription factor binding to the rat insulin-1 gene promoter.
Goodison S; Miyazaki J; Ashcroft SJ
Biochem Biophys Res Commun; 1994 Aug; 203(1):702-10. PubMed ID: 8074725
[TBL] [Abstract][Full Text] [Related]
16. Differentiation between glucose-induced desensitization of insulin secretion and beta-cell exhaustion in the HIT-T15 cell line.
Kilpatrick ED; Robertson RP
Diabetes; 1998 Apr; 47(4):606-11. PubMed ID: 9568694
[TBL] [Abstract][Full Text] [Related]
17. Role of oxidative stress in pancreatic beta-cell dysfunction.
Kajimoto Y; Kaneto H
Ann N Y Acad Sci; 2004 Apr; 1011():168-76. PubMed ID: 15126294
[TBL] [Abstract][Full Text] [Related]
18. Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus.
Seufert J; Weir GC; Habener JF
J Clin Invest; 1998 Jun; 101(11):2528-39. PubMed ID: 9616224
[TBL] [Abstract][Full Text] [Related]
19. Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection.
Robertson RP; Harmon J; Tran PO; Tanaka Y; Takahashi H
Diabetes; 2003 Mar; 52(3):581-7. PubMed ID: 12606496
[TBL] [Abstract][Full Text] [Related]
20. The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells.
Watada H; Kajimoto Y; Umayahara Y; Matsuoka T; Kaneto H; Fujitani Y; Kamada T; Kawamori R; Yamasaki Y
Diabetes; 1996 Nov; 45(11):1478-88. PubMed ID: 8866550
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]