147 related articles for article (PubMed ID: 9022805)
1. Analogues of methotrexate in rheumatoid arthritis. 2. Effects of 5-deazaaminopterin, 5,10-dideazaaminopterin, and analogues on type II collagen-induced arthritis in mice.
Piper JR; DeGraw JI; Colwell WT; Johnson CA; Smith RL; Waud WR; Sirotnak FM
J Med Chem; 1997 Jan; 40(3):377-84. PubMed ID: 9022805
[TBL] [Abstract][Full Text] [Related]
2. Analogues of methotrexate in rheumatoid arthritis. 1. Effects of 10-deazaaminopterin analogues on type II collagen-induced arthritis in mice.
DeGraw JI; Colwell WT; Crase J; Smith RL; Piper JR; Waud WR; Sirotnak FM
J Med Chem; 1997 Jan; 40(3):370-6. PubMed ID: 9022804
[TBL] [Abstract][Full Text] [Related]
3. Analogues of 10-deazaaminopterin and 5-alkyl-5,10-dideazaaminopterin with the 4-substituted 1-naphthoyl group in the place of 4-substituted benzoyl.
Piper JR; Ramamurthy B; Johnson CA; Otter GM; Sirotnak FM
J Med Chem; 1996 Jan; 39(2):614-8. PubMed ID: 8558535
[TBL] [Abstract][Full Text] [Related]
4. Structural design, biochemical properties, and evidence for improved therapeutic activity of 5-alkyl derivatives of 5-deazaaminopterin and 5-deazamethotrexate compared to methotrexate in murine tumor models.
Sirotnak FM; Schmid FA; Otter GM; Piper JR; Montgomery JA
Cancer Res; 1988 Oct; 48(20):5686-91. PubMed ID: 3167828
[TBL] [Abstract][Full Text] [Related]
5. Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.
Piper JR; McCaleb GS; Montgomery JA; Kisliuk RL; Gaumont Y; Sirotnak FM
J Med Chem; 1986 Jun; 29(6):1080-7. PubMed ID: 2423690
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and in vitro biological activity of new deaza analogues of folic acid, aminopterin, and methotrexate with an L-ornithine side chain.
Rosowsky A; Forsch RA; Bader H; Freisheim JH
J Med Chem; 1991 Apr; 34(4):1447-54. PubMed ID: 2016722
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and antifolate properties of 10-alkyl-8,10-dideazaminopterins.
DeGraw JI; Christie PH; Brown EG; Kelly LF; Kisliuk RL; Gaumont Y; Sirotnak FM
J Med Chem; 1984 Mar; 27(3):376-80. PubMed ID: 6699882
[TBL] [Abstract][Full Text] [Related]
8. Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.
Samuels LL; Moccio DM; Sirotnak FM
Cancer Res; 1985 Apr; 45(4):1488-95. PubMed ID: 3978616
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and potent antifolate activity and cytotoxicity of B-ring deaza analogues of the nonpolyglutamatable dihydrofolate reductase inhibitor Nalpha-(4-amino-4-deoxypteroyl)-Ndelta-hemiphthaloyl- L-ornithine (PT523).
Rosowsky A; Wright JE; Vaidya CM; Bader H; Forsch RA; Mota CE; Pardo J; Chen CS; Chen YN
J Med Chem; 1998 Dec; 41(26):5310-9. PubMed ID: 9857098
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and antifolate evaluation of 10-ethyl-5-methyl-5,10- dideazaaminopterin and an alternative synthesis of 10-ethyl-10- deazaaminopterin (edatrexate).
Piper JR; Johnson CA; Otter GM; Sirotnak FM
J Med Chem; 1992 Aug; 35(16):3002-6. PubMed ID: 1501226
[TBL] [Abstract][Full Text] [Related]
11. Differing specificities for 4-aminofolate analogues of folylpolyglutamyl synthetase from tumors and proliferative intestinal epithelium of the mouse with significance for selective antitumor action.
Rumberger BG; Barrueco JR; Sirotnak FM
Cancer Res; 1990 Aug; 50(15):4639-43. PubMed ID: 2369741
[TBL] [Abstract][Full Text] [Related]
12. Cytotoxicity, uptake, polyglutamate formation, and antileukemic effects of 8-deaza analogues of methotrexate and aminopterin in mice.
Kuehl M; Brixner DI; Broom AD; Avery TL; Blakley RL
Cancer Res; 1988 Mar; 48(6):1481-8. PubMed ID: 2449950
[TBL] [Abstract][Full Text] [Related]
13. Inhibitory action of 10-deazaaminopterins and their polyglutamates on human thymidylate synthase.
Ueda T; Dutschman GE; Nair MG; Degraw JI; Sirotnak FM; Cheng YC
Mol Pharmacol; 1986 Aug; 30(2):149-53. PubMed ID: 2426568
[TBL] [Abstract][Full Text] [Related]
14. Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-amino-4-deoxy-5,8,10-trideazapteroyl-d,l-4'-methyleneglutamic acid (CH-1504) and its analogs.
McGuire JJ; Haile WH
Biochem Pharmacol; 2009 Apr; 77(7):1161-72. PubMed ID: 19174154
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin.
DeGraw JI; Colwell WT; Piper JR; Sirotnak FM
J Med Chem; 1993 Jul; 36(15):2228-31. PubMed ID: 8340923
[TBL] [Abstract][Full Text] [Related]
16. New thiophene substituted 10-deazaaminopterins: synthesis and biological evaluation.
Abraham A; McGuire JJ; Galivan J; Vishnuvajjala BR; Nair MG
Adv Exp Med Biol; 1993; 338():421-4. PubMed ID: 8304149
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin.
Piper JR; Malik ND; Rhee MS; Galivan J; Sirotnak FM
J Med Chem; 1992 Jan; 35(2):332-7. PubMed ID: 1732551
[TBL] [Abstract][Full Text] [Related]
18. Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase.
Piper JR; McCaleb GS; Montgomery JA; Kisliuk RL; Gaumont Y; Thorndike J; Sirotnak FM
J Med Chem; 1988 Nov; 31(11):2164-9. PubMed ID: 3184124
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin.
DeGraw JI; Christie PH; Colwell WT; Sirotnak FM
J Med Chem; 1992 Jan; 35(2):320-4. PubMed ID: 1732549
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and biological activities of 5-deaza analogues of aminopterin and folic acid.
Su TL; Huang JT; Burchenal JH; Watanabe KA; Fox JJ
J Med Chem; 1986 May; 29(5):709-15. PubMed ID: 3754585
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
