125 related articles for article (PubMed ID: 9028337)
1. Protoporphyria induced by the orally active iron chelator 1,2-diethyl-3-hydroxypyridin-4-one in C57BL/10ScSn mice.
Smith AG; Clothier B; Francis JE; Gibbs AH; De Matteis F; Hider RC
Blood; 1997 Feb; 89(3):1045-51. PubMed ID: 9028337
[TBL] [Abstract][Full Text] [Related]
2. Effect of iron overload on the metabolism and urinary recovery of 3-hydroxypyridin-4-one chelating agents in the rat.
Choudhury R; Singh S
Drug Metab Dispos; 1995 Mar; 23(3):314-20. PubMed ID: 7628295
[TBL] [Abstract][Full Text] [Related]
3. Formation of N-methyl protoporphyrin in chemically-induced protoporphyria. Studies with a novel porphyrogenic agent.
Frater Y; Brady A; Lock EA; De Matteis F
Arch Toxicol; 1993; 67(3):179-85. PubMed ID: 8494497
[TBL] [Abstract][Full Text] [Related]
4. Contrasting interspecies efficacy and toxicology of 1,2-diethyl-3-hydroxypyridin-4-one, CP94, relates to differing metabolism of the iron chelating site.
Porter JB; Abeysinghe RD; Hoyes KP; Barra C; Huehns ER; Brooks PN; Blackwell MP; Araneta M; Brittenham G; Singh S
Br J Haematol; 1993 Sep; 85(1):159-68. PubMed ID: 8251385
[TBL] [Abstract][Full Text] [Related]
5. Metabolism and pharmacokinetics of 1-(2'-trimethylacetoxyethyl)-2-ethyl-3-hydroxypyridin-4-one (CP117) in the rat.
Choudhury R; Epemolu RO; Rai BL; Hider RC; Singh S
Drug Metab Dispos; 1997 Mar; 25(3):332-9. PubMed ID: 9172951
[TBL] [Abstract][Full Text] [Related]
6. Inhibition of iron toxicity in rat and human hepatocyte cultures by the hydroxypyridin-4-ones CP20 and CP94.
Chenoufi N; Hubert N; Loréal O; Morel I; Pasdeloup N; Cillard J; Brissot P; Lescoat G
J Hepatol; 1995 Aug; 23(2):166-73. PubMed ID: 7499788
[TBL] [Abstract][Full Text] [Related]
7. Urinary metabolic profiles in human and rat of 1,2-dimethyl- and 1,2-diethyl-substituted 3-hydroxypyridin-4-ones.
Singh S; Epemolu RO; Dobbin PS; Tilbrook GS; Ellis BL; Damani LA; Hider RC
Drug Metab Dispos; 1992; 20(2):256-61. PubMed ID: 1352218
[TBL] [Abstract][Full Text] [Related]
8. Liver iron depletion and toxicity of the iron chelator deferiprone (L1, CP20) in the guinea pig.
Wong A; Alder V; Robertson D; Papadimitriou J; Maserei J; Berdoukas V; Kontoghiorghes G; Taylor E; Baker E
Biometals; 1997 Oct; 10(4):247-56. PubMed ID: 9353871
[TBL] [Abstract][Full Text] [Related]
9. Relative oral efficacy and acute toxicity of hydroxypyridin-4-one iron chelators in mice.
Porter JB; Morgan J; Hoyes KP; Burke LC; Huehns ER; Hider RC
Blood; 1990 Dec; 76(11):2389-96. PubMed ID: 2257308
[TBL] [Abstract][Full Text] [Related]
10. Comparison of the subacute toxicity and efficacy of 3-hydroxypyridin-4-one iron chelators in overloaded and nonoverloaded mice.
Porter JB; Hoyes KP; Abeysinghe RD; Brooks PN; Huehns ER; Hider RC
Blood; 1991 Nov; 78(10):2727-34. PubMed ID: 1824264
[TBL] [Abstract][Full Text] [Related]
11. Characterization of two isomeric beta-d-glucosiduronic acids derived from 1,2-diethyl-3-hydroxypyridin-4-one (CP94) in rat liver homogenate incubates.
Liu DY; Liu ZD; Piyamongkol S; Lu SL; Hider RC
J Pharm Pharmacol; 2002 Jul; 54(7):951-7. PubMed ID: 12162714
[TBL] [Abstract][Full Text] [Related]
12. Lessons from preclinical and clinical studies with 1,2-diethyl-3-hydroxypyridin-4-one, CP94 and related compounds.
Porter JB; Singh S; Hoyes KP; Epemolu O; Abeysinghe RD; Hider RC
Adv Exp Med Biol; 1994; 356():361-70. PubMed ID: 7887242
[No Abstract] [Full Text] [Related]
13. Formation of zinc protoporphyrin in cultured hepatocytes: effects of ferrochelatase inhibition, iron chelation or lead.
Jacobs JM; Sinclair PR; Sinclair JF; Gorman N; Walton HS; Wood SG; Nichols C
Toxicology; 1998 Feb; 125(2-3):95-105. PubMed ID: 9570325
[TBL] [Abstract][Full Text] [Related]
14. In vivo and in vitro effects of 3-hydroxypyridin-4-one chelators on murine hemopoiesis.
Hoyes KP; Jones HM; Abeysinghe RD; Hider RC; Porter JB
Exp Hematol; 1993 Jan; 21(1):86-92. PubMed ID: 8417963
[TBL] [Abstract][Full Text] [Related]
15. Subcellular distribution of desferrioxamine and hydroxypyridin-4-one chelators in K562 cells affects chelation of intracellular iron pools.
Hoyes KP; Porter JB
Br J Haematol; 1993 Oct; 85(2):393-400. PubMed ID: 8280612
[TBL] [Abstract][Full Text] [Related]
16. The efficacy of an iron chelator (CP94) in increasing cellular protoporphyrin IX following intravesical 5-aminolaevulinic acid administration: an in vivo study.
Chang SC; MacRobert AJ; Porter JB; Bown SG
J Photochem Photobiol B; 1997 Apr; 38(2-3):114-22. PubMed ID: 9203372
[TBL] [Abstract][Full Text] [Related]
17. Biliary and urinary metabolic profiles of 1,2-diethyl-3-hydroxypyridin-4-one (CP94) in the rat.
Lu SL; Gosriwatana I; Liu DY; Liu ZD; Mallet AI; Hider RC
Drug Metab Dispos; 2000 Aug; 28(8):873-9. PubMed ID: 10901694
[TBL] [Abstract][Full Text] [Related]
18. Synthesis, physicochemical properties and biological evaluation of aromatic ester prodrugs of 1-(2'-hydroxyethyl)-2-ethyl-3-hydroxypyridin-4-one (CP102): orally active iron chelators with clinical potential.
Liu ZD; Liu DY; Lu SL; Hider RC
J Pharm Pharmacol; 1999 May; 51(5):555-64. PubMed ID: 10411215
[TBL] [Abstract][Full Text] [Related]
19. A hydroxypyridinone (CP94) enhances protoporphyrin IX formation in 5-aminolaevulinic acid treated cells.
Bech O; Phillips D; Moan J; MacRobert AJ
J Photochem Photobiol B; 1997 Nov; 41(1-2):136-44. PubMed ID: 9440321
[TBL] [Abstract][Full Text] [Related]
20. Potentiation of iron accumulation in cardiac myocytes during the treatment of iron overload in gerbils with the hydroxypyridinone iron chelator CP94.
Carthew P; Smith AG; Hider RC; Dorman B; Edwards RE; Francis JE
Biometals; 1994 Oct; 7(4):267-71. PubMed ID: 7812111
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
