109 related articles for article (PubMed ID: 9046334)
1. Chromophore-modified bis-naphthalimides: synthesis and antitumor activity of bis-dibenz[de,h]isoquinoline-1,3-diones.
Braña MF; Castellano JM; Perron D; Maher C; Conlon D; Bousquet PF; George J; Qian XD; Robinson SP
J Med Chem; 1997 Feb; 40(4):449-54. PubMed ID: 9046334
[TBL] [Abstract][Full Text] [Related]
2. Bis-naphthalimides 3: synthesis and antitumor activity of N,N'-bis[2-(1,8-naphthalimido)-ethyl] alkanediamines.
Braña MF; Castellano JM; Morán M; Pérez de Vega MJ; Perron D; Conlon D; Bousquet PF; Romerdahl CA; Robinson SP
Anticancer Drug Des; 1996 Jun; 11(4):297-309. PubMed ID: 8679053
[TBL] [Abstract][Full Text] [Related]
3. 2-[2'-(Dimethylamino)ethyl]-1,2-dihydro- 3H-dibenz[de,h]isoquinoline-1,3-diones with substituents at positions 4, 8, 9, 10, and 11. Synthesis, antitumor activity, and quantitative structure-activity relationships.
Sami SM; Dorr RT; Alberts DS; Sólyom AM; Remers WA
J Med Chem; 1996 Dec; 39(25):4978-87. PubMed ID: 8960558
[TBL] [Abstract][Full Text] [Related]
4. Structure-activity relationships for substituted bis(acridine-4-carboxamides): a new class of anticancer agents.
Gamage SA; Spicer JA; Atwell GJ; Finlay GJ; Baguley BC; Denny WA
J Med Chem; 1999 Jul; 42(13):2383-93. PubMed ID: 10395479
[TBL] [Abstract][Full Text] [Related]
5. 6- and 7-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h] isoquinoline-1,3-diones: synthesis, nucleophilic displacements, antitumor activity, and quantitative structure-activity relationships.
Sami SM; Dorr RT; Sòlyom AM; Alberts DS; Iyengar BS; Remers WA
J Med Chem; 1996 Apr; 39(8):1609-18. PubMed ID: 8648600
[TBL] [Abstract][Full Text] [Related]
6. Synthesis, cytotoxicity, DNA interaction, and topoisomerase II inhibition properties of novel indeno[2,1-c]quinolin-7-one and indeno[1,2-c]isoquinolin-5,11-dione derivatives.
Ryckebusch A; Garcin D; Lansiaux A; Goossens JF; Baldeyrou B; Houssin R; Bailly C; Hénichart JP
J Med Chem; 2008 Jun; 51(12):3617-29. PubMed ID: 18507368
[TBL] [Abstract][Full Text] [Related]
7. Bis-naphthalimides: a new class of antitumor agents.
Braña MF; Castellano JM; Morán M; Pérez de Vega MJ; Romerdahl CR; Qian XD; Bousquet P; Emling F; Schlick E; Keilhauer G
Anticancer Drug Des; 1993 Aug; 8(4):257-68. PubMed ID: 8240655
[TBL] [Abstract][Full Text] [Related]
8. Synthesis, cytotoxicity and topoisomerase inhibition properties of multifarious aminoalkylated indeno[1,2-c]isoquinolin-5,11-diones.
Ahn G; Schifano-Faux N; Goossens JF; Baldeyrou B; Couture A; Grandclaudon P; Lansiaux A; Ryckebusch A
Bioorg Med Chem Lett; 2011 Apr; 21(8):2259-63. PubMed ID: 21439821
[TBL] [Abstract][Full Text] [Related]
9. Design, synthesis, and biological evaluation of new mitonafide derivatives as potential antitumor drugs.
Antonini I; Volpini R; Dal Ben D; Lambertucci C; Cristalli G
Bioorg Med Chem; 2008 Sep; 16(18):8440-6. PubMed ID: 18774722
[TBL] [Abstract][Full Text] [Related]
10. Discovery of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4.
Tsou HR; Liu X; Birnberg G; Kaplan J; Otteng M; Tran T; Kutterer K; Tang Z; Suayan R; Zask A; Ravi M; Bretz A; Grillo M; McGinnis JP; Rabindran SK; Ayral-Kaloustian S; Mansour TS
J Med Chem; 2009 Apr; 52(8):2289-310. PubMed ID: 19317452
[TBL] [Abstract][Full Text] [Related]
11. Identification and characterization of in vitro metabolites of 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz [de,h]isoquinoline-1,3-dione (Azonafide).
Mayr CA; Sami SM; Remers WA; Dorr RT
Drug Metab Dispos; 1998 Feb; 26(2):105-9. PubMed ID: 9456295
[TBL] [Abstract][Full Text] [Related]
12. Antitumor agents. 3. Design, synthesis, and biological evaluation of new pyridoisoquinolindione and dihydrothienoquinolindione derivatives with potent cytotoxic activity.
Bolognese A; Correale G; Manfra M; Lavecchia A; Mazzoni O; Novellino E; La Colla P; Sanna G; Loddo R
J Med Chem; 2004 Feb; 47(4):849-58. PubMed ID: 14761187
[TBL] [Abstract][Full Text] [Related]
13. Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons.
Strumberg D; Pommier Y; Paull K; Jayaraman M; Nagafuji P; Cushman M
J Med Chem; 1999 Feb; 42(3):446-57. PubMed ID: 9986716
[TBL] [Abstract][Full Text] [Related]
14. Design, synthesis, and biological evaluation of indenoisoquinoline topoisomerase I inhibitors featuring polyamine side chains on the lactam nitrogen.
Nagarajan M; Xiao X; Antony S; Kohlhagen G; Pommier Y; Cushman M
J Med Chem; 2003 Dec; 46(26):5712-24. PubMed ID: 14667224
[TBL] [Abstract][Full Text] [Related]
15. The anti-inflammatory activity of 5H-dibenz[c,e]azepine-5,7(6H)dione, 6,7-dihydro-5H-dibenz[c,e]azepine, N-benzoylbenzamide and 1H-benz[d,e]isoquinoline-1,3(2H)dione derivatives in rodents.
Hall IH; Simlot R; Oswald CB; Murthy AR; elSourady H; Chapman JM
Acta Pharm Nord; 1990; 2(6):387-400. PubMed ID: 2095797
[TBL] [Abstract][Full Text] [Related]
16. Indeno[1,2-c]isoquinolin-5,11-diones conjugated to amino acids: Synthesis, cytotoxicity, DNA interaction, and topoisomerase II inhibition properties.
Ahn G; Lansiaux A; Goossens JF; Bailly C; Baldeyrou B; Schifano-Faux N; Grandclaudon P; Couture A; Ryckebusch A
Bioorg Med Chem; 2010 Nov; 18(22):8119-33. PubMed ID: 20961767
[TBL] [Abstract][Full Text] [Related]
17. The bis(naphthalimide) DMP-840 causes cytotoxicity by its action against eukaryotic topoisomerase II.
Nitiss JL; Zhou J; Rose A; Hsiung Y; Gale KC; Osheroff N
Biochemistry; 1998 Mar; 37(9):3078-85. PubMed ID: 9485461
[TBL] [Abstract][Full Text] [Related]
18. Synthesis, structure and antitumor activity of new benz[d,e]isoquinoline-1,3-diones.
Braña MF; Castellano JM; Morán M; Emling F; Kluge M; Schlick E; Klebe G; Walker N
Arzneimittelforschung; 1995 Dec; 45(12):1311-8. PubMed ID: 8595091
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis.
Ioanoviciu A; Antony S; Pommier Y; Staker BL; Stewart L; Cushman M
J Med Chem; 2005 Jul; 48(15):4803-14. PubMed ID: 16033260
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and evaluation of new antitumor 3-aminomethyl-4,11-dihydroxynaphtho[2,3-f]indole-5,10-diones.
Shchekotikhin AE; Glazunova VA; Dezhenkova LG; Luzikov YN; Buyanov VN; Treshalina HM; Lesnaya NA; Romanenko VI; Kaluzhny DN; Balzarini J; Agama K; Pommier Y; Shtil AA; Preobrazhenskaya MN
Eur J Med Chem; 2014 Oct; 86():797-805. PubMed ID: 25244612
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]