BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

146 related articles for article (PubMed ID: 9048569)

  • 1. Purification and characterization of bimodular and trimodular derivatives of the erythromycin polyketide synthase.
    Pieper R; Gokhale RS; Luo G; Cane DE; Khosla C
    Biochemistry; 1997 Feb; 36(7):1846-51. PubMed ID: 9048569
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Origin of starter units for erythromycin biosynthesis.
    Weissman KJ; Bycroft M; Staunton J; Leadlay PF
    Biochemistry; 1998 Aug; 37(31):11012-7. PubMed ID: 9692995
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units.
    Lau J; Fu H; Cane DE; Khosla C
    Biochemistry; 1999 Feb; 38(5):1643-51. PubMed ID: 9931032
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Erythromycin biosynthesis: kinetic studies on a fully active modular polyketide synthase using natural and unnatural substrates.
    Pieper R; Ebert-Khosla S; Cane D; Khosla C
    Biochemistry; 1996 Feb; 35(7):2054-60. PubMed ID: 8652546
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase.
    Kao CM; Pieper R; Cane DE; Khosla C
    Biochemistry; 1996 Sep; 35(38):12363-8. PubMed ID: 8823171
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Functional orientation of the acyltransferase domain in a module of the erythromycin polyketide synthase.
    Gokhale RS; Lau J; Cane DE; Khosla C
    Biochemistry; 1998 Feb; 37(8):2524-8. PubMed ID: 9485401
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase leads to polyketide biosynthesis.
    Jacobsen JR; Cane DE; Khosla C
    Biochemistry; 1998 Apr; 37(14):4928-34. PubMed ID: 9538011
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules.
    Hans M; Hornung A; Dziarnowski A; Cane DE; Khosla C
    J Am Chem Soc; 2003 May; 125(18):5366-74. PubMed ID: 12720450
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The molecular basis of Celmer's rules: the stereochemistry of the condensation step in chain extension on the erythromycin polyketide synthase.
    Weissman KJ; Timoney M; Bycroft M; Grice P; Hanefeld U; Staunton J; Leadlay PF
    Biochemistry; 1997 Nov; 36(45):13849-55. PubMed ID: 9374862
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of domains within megalomicin and erythromycin polyketide synthase modules responsible for differences in polyketide production levels in Escherichia coli.
    Murli S; Piagentini M; McDaniel R; Hutchinson CR
    Biochemistry; 2004 Dec; 43(50):15884-90. PubMed ID: 15595843
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A model of structure and catalysis for ketoreductase domains in modular polyketide synthases.
    Reid R; Piagentini M; Rodriguez E; Ashley G; Viswanathan N; Carney J; Santi DV; Hutchinson CR; McDaniel R
    Biochemistry; 2003 Jan; 42(1):72-9. PubMed ID: 12515540
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The acyltransferase homologue from the initiation module of the R1128 polyketide synthase is an acyl-ACP thioesterase that edits acetyl primer units.
    Tang Y; Koppisch AT; Khosla C
    Biochemistry; 2004 Jul; 43(29):9546-55. PubMed ID: 15260498
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase.
    Gokhale RS; Hunziker D; Cane DE; Khosla C
    Chem Biol; 1999 Feb; 6(2):117-25. PubMed ID: 10021418
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Efficient purification and kinetic characterization of a bimodular derivative of the erythromycin polyketide synthase.
    Bycroft M; Weissman KJ; Staunton J; Leadlay PF
    Eur J Biochem; 2000 Jan; 267(2):520-6. PubMed ID: 10632721
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases.
    Liou GF; Lau J; Cane DE; Khosla C
    Biochemistry; 2003 Jan; 42(1):200-7. PubMed ID: 12515555
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase.
    Kim CY; Alekseyev VY; Chen AY; Tang Y; Cane DE; Khosla C
    Biochemistry; 2004 Nov; 43(44):13892-8. PubMed ID: 15518537
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity.
    Tang Y; Lee TS; Kobayashi S; Khosla C
    Biochemistry; 2003 Jun; 42(21):6588-95. PubMed ID: 12767243
    [TBL] [Abstract][Full Text] [Related]  

  • 18. 6-deoxyerythronolide B synthase 1 is specifically acylated by a diketide intermediate at the beta-ketoacyl-acyl carrier protein synthase domain of module 2.
    Tsukamoto N; Chuck JA; Luo G; Kao CM; Khosla C; Cane DE
    Biochemistry; 1996 Dec; 35(48):15244-8. PubMed ID: 8952473
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Engineered intermodular and intramodular polyketide synthase fusions.
    McDaniel R; Kao CM; Hwang SJ; Khosla C
    Chem Biol; 1997 Sep; 4(9):667-74. PubMed ID: 9331407
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases.
    Pieper R; Luo G; Cane DE; Khosla C
    Nature; 1995 Nov; 378(6554):263-6. PubMed ID: 7477343
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.