These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

140 related articles for article (PubMed ID: 9089285)

  • 1. The glutamine ligand in the ferrous iron active site of isopenicillin N synthase of Streptomyces jumonjinensis is not essential for catalysis.
    Landman O; Borovok I; Aharonowitz Y; Cohen G
    FEBS Lett; 1997 Mar; 405(2):172-4. PubMed ID: 9089285
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-function studies of the non-heme iron active site of isopenicillin N synthase: some implications for catalysis.
    Kreisberg-Zakarin R; Borovok I; Yanko M; Frolow F; Aharonowitz Y; Cohen G
    Biophys Chem; 2000 Aug; 86(2-3):109-18. PubMed ID: 11026676
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ferrous active site of isopenicillin N synthase: genetic and sequence analysis of the endogenous ligands.
    Borovok I; Landman O; Kreisberg-Zakarin R; Aharonowitz Y; Cohen G
    Biochemistry; 1996 Feb; 35(6):1981-7. PubMed ID: 8639682
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Catalytic activity in Cephalosporium acremonium isopenicillin N synthase does not involve glutamine-234.
    Loke P; Sim TS
    Biochem Biophys Res Commun; 1998 Jul; 248(3):559-61. PubMed ID: 9703965
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Glutamine-230 influences enzyme solubility but not catalysis in Streptomyces clavuligerus isopenicillin N synthase.
    Loke P; Sim TS
    FEMS Microbiol Lett; 1999 Apr; 173(2):439-43. PubMed ID: 10227172
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-alpha-aminoadipoyl)-L-cysteinyl-glycine and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alanine.
    Long AJ; Clifton IJ; Roach PL; Baldwin JE; Rutledge PJ; Schofield CJ
    Biochemistry; 2005 May; 44(17):6619-28. PubMed ID: 15850395
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate.
    Long AJ; Clifton IJ; Roach PL; Baldwin JE; Schofield CJ; Rutledge PJ
    Biochem J; 2003 Jun; 372(Pt 3):687-93. PubMed ID: 12622704
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A heuristic approach to the analysis of enzymic catalysis: reaction of delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alpha-aminobutyrate and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-allylglycine catalyzed by isopenicillin N synthase isozymes.
    Blackburn JM; Sutherland JD; Baldwin JE
    Biochemistry; 1995 Jun; 34(22):7548-62. PubMed ID: 7779800
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Recent advances in the structure and function of isopenicillin N synthase.
    Kreisberg-Zakarin R; Borovok I; Yanko M; Aharonowitz Y; Cohen G
    Antonie Van Leeuwenhoek; 1999; 75(1-2):33-9. PubMed ID: 10422580
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Glutamine-330 is not essential for activity in isopenicillin N synthase from Aspergillus nidulans.
    Sami M; Brown TJ; Roach PL; Schofield CJ; Baldwin JE
    FEBS Lett; 1997 Mar; 405(2):191-4. PubMed ID: 9089289
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Crystallographic studies on the reaction of isopenicillin N synthase with an unsaturated substrate analogue.
    Elkins JM; Rutledge PJ; Burzlaff NI; Clifton IJ; Adlington RM; Roach PL; Baldwin JE
    Org Biomol Chem; 2003 May; 1(9):1455-60. PubMed ID: 12926272
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Metal-catalyzed oxidation and mutagenesis studies on the iron(II) binding site of 1-aminocyclopropane-1-carboxylate oxidase.
    Zhang Z; Barlow JN; Baldwin JE; Schofield CJ
    Biochemistry; 1997 Dec; 36(50):15999-6007. PubMed ID: 9398335
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non-Heme Iron Oxidases.
    McNeill LA; Brown TJN; Sami M; Clifton IJ; Burzlaff NI; Claridge TDW; Adlington RM; Baldwin JE; Rutledge PJ; Schofield CJ
    Chemistry; 2017 Sep; 23(52):12815-12824. PubMed ID: 28703303
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mutational evidence for the role of serine-283 in Cephalosporium acremonium isopenicillin N synthase.
    Loke P; Sim TS
    FEMS Microbiol Lett; 1998 Aug; 165(2):353-6. PubMed ID: 9841222
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The interaction of isopenicillin N synthase with homologated substrate analogues δ-(L-α-aminoadipoyl)-L-homocysteinyl-D-Xaa characterised by protein crystallography.
    Daruzzaman A; Clifton IJ; Adlington RM; Baldwin JE; Rutledge PJ
    Chembiochem; 2013 Mar; 14(5):599-606. PubMed ID: 23468426
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The crystal structure of an isopenicillin N synthase complex with an ethereal substrate analogue reveals water in the oxygen binding site.
    Clifton IJ; Ge W; Adlington RM; Baldwin JE; Rutledge PJ
    FEBS Lett; 2013 Aug; 587(16):2705-9. PubMed ID: 23860486
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Spectroscopic studies reveal details of substrate-induced conformational changes distant from the active site in isopenicillin N synthase.
    Rabe P; Walla CC; Goodyear NK; Welsh J; Southwart R; Clifton I; Linyard JDS; Tumber A; Claridge TDW; Myers WK; Schofield CJ
    J Biol Chem; 2022 Sep; 298(9):102249. PubMed ID: 35835215
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The invariant F283 and its strategic position in the hydrophobic cleft of Streptomyces jumonjinensis isopenicillin N synthase active site are functionally important.
    Wong E; Sim J; Sim TS
    Biochem Biophys Res Commun; 2001 May; 283(3):621-6. PubMed ID: 11341769
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Thiolate ligation of the active site Fe2+ of isopenicillin N synthase derives from substrate rather than endogenous cysteine: spectroscopic studies of site-specific Cys----Ser mutated enzymes.
    Orville AM; Chen VJ; Kriauciunas A; Harpel MR; Fox BG; Münck E; Lipscomb JD
    Biochemistry; 1992 May; 31(19):4602-12. PubMed ID: 1316153
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Analysis of glutamines in catalysis in Cephalosporium acremonium isopenicillin N synthase by site-directed mutagenesis.
    Loke P; Sim TS
    Biochem Biophys Res Commun; 1998 Nov; 252(2):472-5. PubMed ID: 9826554
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.