These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
460 related articles for article (PubMed ID: 9100016)
1. Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady-state catalysis. Spencer HT; Villafranca JE; Appleman JR Biochemistry; 1997 Apr; 36(14):4212-22. PubMed ID: 9100016 [TBL] [Abstract][Full Text] [Related]
2. Crystal structures of thymidylate synthase mutant R166Q: structural basis for the nearly complete loss of catalytic activity. Sotelo-Mundo RR; Changchien L; Maley F; Montfort WR J Biochem Mol Toxicol; 2006; 20(2):88-92. PubMed ID: 16615077 [TBL] [Abstract][Full Text] [Related]
3. Substitution at residue 214 of human thymidylate synthase alters nucleotide binding and isomerization of ligand-protein complexes. Steadman DJ; Spencer HT; Dunlap RB; Berger SH Biochemistry; 1999 Apr; 38(17):5582-7. PubMed ID: 10220346 [TBL] [Abstract][Full Text] [Related]
4. Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254. Fantz C; Shaw D; Jennings W; Forsthoefel A; Kitchens M; Phan J; Minor W; Lebioda L; Berger FG; Spencer HT Mol Pharmacol; 2000 Feb; 57(2):359-66. PubMed ID: 10648646 [TBL] [Abstract][Full Text] [Related]
5. An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q. Sage CR; Rutenber EE; Stout TJ; Stroud RM Biochemistry; 1996 Dec; 35(50):16270-81. PubMed ID: 8973201 [TBL] [Abstract][Full Text] [Related]
6. Nonconserved residues Ala287 and Ser290 of the Cryptosporidium hominis thymidylate synthase domain facilitate its rapid rate of catalysis. Doan LT; Martucci WE; Vargo MA; Atreya CE; Anderson KS Biochemistry; 2007 Jul; 46(28):8379-91. PubMed ID: 17580969 [TBL] [Abstract][Full Text] [Related]
7. Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4. Mahdavian E; Spencer HT; Dunlap RB Arch Biochem Biophys; 1999 Aug; 368(2):257-64. PubMed ID: 10441376 [TBL] [Abstract][Full Text] [Related]
9. D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine. Sage CR; Michelitsch MD; Stout TJ; Biermann D; Nissen R; Finer-Moore J; Stroud RM Biochemistry; 1998 Sep; 37(39):13893-901. PubMed ID: 9753479 [TBL] [Abstract][Full Text] [Related]
10. Subunit complementation of thymidylate synthase in Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase. Chanama M; Chitnumsub P; Yuthavong Y Mol Biochem Parasitol; 2005 Jan; 139(1):83-90. PubMed ID: 15610822 [TBL] [Abstract][Full Text] [Related]
11. Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate. Matthews DA; Villafranca JE; Janson CA; Smith WW; Welsh K; Freer S J Mol Biol; 1990 Aug; 214(4):937-48. PubMed ID: 2201779 [TBL] [Abstract][Full Text] [Related]
12. Functional identity of the active sites of crustacean and viral thymidylate synthases. Arvizu-Flores AA; Aispuro-Hernandez E; Garcia-Orozco KD; Varela-Romero A; Valenzuela-Soto E; Velazquez-Contreras EF; Rojo-Domínguez A; Yepiz-Plascencia G; Maley F; Sotelo-Mundo RR Comp Biochem Physiol C Toxicol Pharmacol; 2009 Sep; 150(3):406-13. PubMed ID: 19559812 [TBL] [Abstract][Full Text] [Related]
13. The catalytic mechanism and structure of thymidylate synthase. Carreras CW; Santi DV Annu Rev Biochem; 1995; 64():721-62. PubMed ID: 7574499 [TBL] [Abstract][Full Text] [Related]
14. Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate. Hyatt DC; Maley F; Montfort WR Biochemistry; 1997 Apr; 36(15):4585-94. PubMed ID: 9109668 [TBL] [Abstract][Full Text] [Related]
15. A hydroxyl group at residue 216 is essential for catalysis by human thymidylate synthase. Williams AW; Dunlap RB; Berger SH Biochemistry; 1998 May; 37(20):7096-102. PubMed ID: 9585520 [TBL] [Abstract][Full Text] [Related]
16. Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase. Finer-Moore JS; Liu L; Schafmeister CE; Birdsall DL; Mau T; Santi DV; Stroud RM Biochemistry; 1996 Apr; 35(16):5125-36. PubMed ID: 8611496 [TBL] [Abstract][Full Text] [Related]
17. Thermodynamic stabilization of nucleotide binding to thymidylate synthase by a potent benzoquinazoline folate analogue inhibitor. Chen CH; Davis RA; Maley F Biochemistry; 1996 Jul; 35(26):8786-93. PubMed ID: 8679643 [TBL] [Abstract][Full Text] [Related]
18. Role of an invariant lysine residue in folate binding on Escherichia coli thymidylate synthase: calorimetric and crystallographic analysis of the K48Q mutant. Arvizu-Flores AA; Sugich-Miranda R; Arreola R; Garcia-Orozco KD; Velazquez-Contreras EF; Montfort WR; Maley F; Sotelo-Mundo RR Int J Biochem Cell Biol; 2008; 40(10):2206-17. PubMed ID: 18403248 [TBL] [Abstract][Full Text] [Related]
19. A stable binary complex between Leishmania major thymidylate synthase and the substrate deoxyuridylate. A slow-binding interaction. Garvey EP; Santi DV J Biol Chem; 1987 Jul; 262(19):9068-74. PubMed ID: 3597407 [TBL] [Abstract][Full Text] [Related]
20. Binding of the anticancer drug ZD1694 to E. coli thymidylate synthase: assessing specificity and affinity. Rutenber EE; Stroud RM Structure; 1996 Nov; 4(11):1317-24. PubMed ID: 8939755 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]