These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

109 related articles for article (PubMed ID: 9117540)

  • 1. Presenilin-1 is processed into two major cleavage products in neuronal cell lines.
    Ward RV; Davis JB; Gray CW; Barton AJ; Bresciani LG; Caivano M; Murphy VF; Duff K; Hutton M; Hardy J; Roberts GW; Karran EH
    Neurodegeneration; 1996 Dec; 5(4):293-8. PubMed ID: 9117540
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
    Podlisny MB; Citron M; Amarante P; Sherrington R; Xia W; Zhang J; Diehl T; Levesque G; Fraser P; Haass C; Koo EH; Seubert P; St George-Hyslop P; Teplow DB; Selkoe DJ
    Neurobiol Dis; 1997; 3(4):325-37. PubMed ID: 9173929
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family.
    Grunberg J; Walter J; Loetscher H; Deuschle U; Jacobsen H; Haass C
    Biochemistry; 1998 Feb; 37(8):2263-70. PubMed ID: 9485372
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Proteolytic processing of presenilin-1 (PS-1) is not associated with Alzheimer's disease with or without PS-1 mutations.
    Okochi M; Ishii K; Usami M; Sahara N; Kametani F; Tanaka K; Fraser PE; Ikeda M; Saunders AM; Hendriks L; Shoji SI; Nee LE; Martin JJ; Van Broeckhoven C; St George-Hyslop PH; Roses AD; Mori H
    FEBS Lett; 1997 Nov; 418(1-2):162-6. PubMed ID: 9414118
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Different effects of Alzheimer-associated mutations of presenilin 1 on its processing.
    Murayama O; Honda T; Mercken M; Murayama M; Yasutake K; Nihonmatsu N; Nakazato Y; Michel G; Song S; Sato K; Takahashi H; Takashima A
    Neurosci Lett; 1997 Jun; 229(1):61-4. PubMed ID: 9224802
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies.
    Diehlmann A; Ida N; Weggen S; Grünberg J; Haass C; Masters CL; Bayer TA; Beyreuther K
    J Neurosci Res; 1999 May; 56(4):405-19. PubMed ID: 10340748
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Determination of a cleavage site of presenilin 2 protein in stably transfected SH-SY5Y human neuroblastoma cell lines.
    Shirotani K; Takahashi K; Ozawa K; Kunishita T; Tabira T
    Biochem Biophys Res Commun; 1997 Nov; 240(3):728-31. PubMed ID: 9398634
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Endoproteolytic processing and stabilization of wild-type and mutant presenilin.
    Ratovitski T; Slunt HH; Thinakaran G; Price DL; Sisodia SS; Borchelt DR
    J Biol Chem; 1997 Sep; 272(39):24536-41. PubMed ID: 9305918
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex.
    Capell A; Grünberg J; Pesold B; Diehlmann A; Citron M; Nixon R; Beyreuther K; Selkoe DJ; Haass C
    J Biol Chem; 1998 Feb; 273(6):3205-11. PubMed ID: 9452432
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Effects of presenilin N-terminal fragments on production of amyloid beta peptide and accumulation of endogenous presenilins.
    Shirotani K; Takahashi K; Tabira T
    Neurosci Lett; 1999 Feb; 262(1):37-40. PubMed ID: 10076867
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Caspase cleavage of exon 9 deleted presenilin-1 is an early event in apoptosis induced by calcium ionophore A 23187 in SH-SY5Y neuroblastoma cells.
    Popescu BO; Cedazo-Minguez A; Popescu LM; Winblad B; Cowburn RF; Ankarcrona M
    J Neurosci Res; 2001 Oct; 66(1):122-34. PubMed ID: 11599009
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A novel presenilin-2 splice variant in human Alzheimer's disease brain tissue.
    Sato N; Hori O; Yamaguchi A; Lambert JC; Chartier-Harlin MC; Robinson PA; Delacourte A; Schmidt AM; Furuyama T; Imaizumi K; Tohyama M; Takagi T
    J Neurochem; 1999 Jun; 72(6):2498-505. PubMed ID: 10349860
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.
    Baumeister R; Leimer U; Zweckbronner I; Jakubek C; Grünberg J; Haass C
    Genes Funct; 1997 Apr; 1(2):149-59. PubMed ID: 9680315
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis.
    Leimer U; Lun K; Romig H; Walter J; Grünberg J; Brand M; Haass C
    Biochemistry; 1999 Oct; 38(41):13602-9. PubMed ID: 10521267
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Evidence for presenilin-1 involvement in amyloid angiopathy in the Alzheimer's disease-affected brain.
    Hayashi Y; Fukatsu R; Tsuzuki K; Yoshida T; Sasaki N; Kimura K; Yamaguchi H; St George-Hyslop PH; Fujii N; Takahata N
    Brain Res; 1998 Apr; 789(2):307-14. PubMed ID: 9573389
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms.
    Walter J; Grünberg J; Schindzielorz A; Haass C
    Biochemistry; 1998 Apr; 37(17):5961-7. PubMed ID: 9558331
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.
    Walter J; Grünberg J; Capell A; Pesold B; Schindzielorz A; Citron M; Mendla K; George-Hyslop PS; Multhaup G; Selkoe DJ; Haass C
    Proc Natl Acad Sci U S A; 1997 May; 94(10):5349-54. PubMed ID: 9144240
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Processing of wild-type and mutant familial Alzheimer's disease-associated presenilin-1 in cultured neurons.
    Weihl CC; Ghadge GD; Miller RJ; Roos RP
    J Neurochem; 1999 Jul; 73(1):31-40. PubMed ID: 10386952
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Characterization of detergent-insoluble complexes containing the familial Alzheimer's disease-associated presenilins.
    Parkin ET; Hussain I; Karran EH; Turner AJ; Hooper NM
    J Neurochem; 1999 Apr; 72(4):1534-43. PubMed ID: 10098859
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
    Walker ES; Martinez M; Brunkan AL; Goate A
    J Neurochem; 2005 Jan; 92(2):294-301. PubMed ID: 15663477
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.