179 related articles for article (PubMed ID: 9144195)
21. Endoproteolytic processing and stabilization of wild-type and mutant presenilin.
Ratovitski T; Slunt HH; Thinakaran G; Price DL; Sisodia SS; Borchelt DR
J Biol Chem; 1997 Sep; 272(39):24536-41. PubMed ID: 9305918
[TBL] [Abstract][Full Text] [Related]
22. Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates.
Kim SH; Ikeuchi T; Yu C; Sisodia SS
J Biol Chem; 2003 Sep; 278(36):33992-4002. PubMed ID: 12821663
[TBL] [Abstract][Full Text] [Related]
23. Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells.
Refolo LM; Eckman C; Prada CM; Yager D; Sambamurti K; Mehta N; Hardy J; Younkin SG
J Neurochem; 1999 Dec; 73(6):2383-8. PubMed ID: 10582597
[TBL] [Abstract][Full Text] [Related]
24. Effects of presenilin N-terminal fragments on production of amyloid beta peptide and accumulation of endogenous presenilins.
Shirotani K; Takahashi K; Tabira T
Neurosci Lett; 1999 Feb; 262(1):37-40. PubMed ID: 10076867
[TBL] [Abstract][Full Text] [Related]
25. Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin.
Massey LK; Mah AL; Monteiro MJ
Biochem J; 2005 Nov; 391(Pt 3):513-25. PubMed ID: 15975090
[TBL] [Abstract][Full Text] [Related]
26. Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis.
Leimer U; Lun K; Romig H; Walter J; Grünberg J; Brand M; Haass C
Biochemistry; 1999 Oct; 38(41):13602-9. PubMed ID: 10521267
[TBL] [Abstract][Full Text] [Related]
27. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex.
Capell A; Grünberg J; Pesold B; Diehlmann A; Citron M; Nixon R; Beyreuther K; Selkoe DJ; Haass C
J Biol Chem; 1998 Feb; 273(6):3205-11. PubMed ID: 9452432
[TBL] [Abstract][Full Text] [Related]
28. Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.
Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; Masters CL
Biochemistry; 2005 Mar; 44(11):4332-41. PubMed ID: 15766262
[TBL] [Abstract][Full Text] [Related]
29. The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin.
Yu G; Chen F; Levesque G; Nishimura M; Zhang DM; Levesque L; Rogaeva E; Xu D; Liang Y; Duthie M; St George-Hyslop PH; Fraser PE
J Biol Chem; 1998 Jun; 273(26):16470-5. PubMed ID: 9632714
[TBL] [Abstract][Full Text] [Related]
30. Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling.
Kirschenbaum F; Hsu SC; Cordell B; McCarthy JV
J Biol Chem; 2001 Mar; 276(10):7366-75. PubMed ID: 11104755
[TBL] [Abstract][Full Text] [Related]
31. Dual roles of proteasome in the metabolism of presenilin 1.
Honda T; Yasutake K; Nihonmatsu N; Mercken M; Takahashi H; Murayama O; Murayama M; Sato K; Omori A; Tsubuki S; Saido TC; Takashima A
J Neurochem; 1999 Jan; 72(1):255-61. PubMed ID: 9886077
[TBL] [Abstract][Full Text] [Related]
32. Akt activity in presenilin 1 wild-type and mutation transfected human SH-SY5Y neuroblastoma cells after serum deprivation and high glucose stress.
Vestling M; Wiehager B; Tanii H; Cowburn RF
J Neurosci Res; 2001 Nov; 66(3):448-56. PubMed ID: 11746362
[TBL] [Abstract][Full Text] [Related]
33. Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation.
Steiner H; Capell A; Pesold B; Citron M; Kloetzel PM; Selkoe DJ; Romig H; Mendla K; Haass C
J Biol Chem; 1998 Nov; 273(48):32322-31. PubMed ID: 9822712
[TBL] [Abstract][Full Text] [Related]
34. Presenilin-1 D257A and D385A mutants fail to cleave Notch in their endoproteolyzed forms, but only presenilin-1 D385A mutant can restore its gamma-secretase activity with the compensatory overexpression of normal C-terminal fragment.
Kim H; Ki H; Park HS; Kim K
J Biol Chem; 2005 Jun; 280(23):22462-72. PubMed ID: 15797863
[TBL] [Abstract][Full Text] [Related]
35. Generation of amyloid beta protein from a presenilin-1 and betaAPP complex.
Shizuka-Ikeda M; Matsubara E; Ikeda M; Kanai M; Tomidokoro Y; Ikeda Y; Watanabe M; Kawarabayashi T; Harigaya Y; Okamoto K; Maruyama K; Castaño EM; St George-Hyslop P; Shoji M
Biochem Biophys Res Commun; 2002 Mar; 292(2):571-8. PubMed ID: 11906199
[TBL] [Abstract][Full Text] [Related]
36. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; Nishimura M; Yanagisawa K; Komano H
J Neurochem; 2004 Sep; 90(6):1402-13. PubMed ID: 15341524
[TBL] [Abstract][Full Text] [Related]
37. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.
Fraering PC; LaVoie MJ; Ye W; Ostaszewski BL; Kimberly WT; Selkoe DJ; Wolfe MS
Biochemistry; 2004 Jan; 43(2):323-33. PubMed ID: 14717586
[TBL] [Abstract][Full Text] [Related]
38. Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.
Steiner H; Winkler E; Haass C
J Biol Chem; 2008 Dec; 283(50):34677-86. PubMed ID: 18801744
[TBL] [Abstract][Full Text] [Related]
39. Zinc enhances synthesis of presenilin 1 in mouse primary cortical culture.
Park IH; Jung MW; Mori H; Mook-Jung I
Biochem Biophys Res Commun; 2001 Jul; 285(3):680-8. PubMed ID: 11453647
[TBL] [Abstract][Full Text] [Related]
40. Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.
Chen F; Yang DS; Petanceska S; Yang A; Tandon A; Yu G; Rozmahel R; Ghiso J; Nishimura M; Zhang DM; Kawarai T; Levesque G; Mills J; Levesque L; Song YQ; Rogaeva E; Westaway D; Mount H; Gandy S; St George-Hyslop P; Fraser PE
J Biol Chem; 2000 Nov; 275(47):36794-802. PubMed ID: 10962005
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]